Article
Fisheries
Taciana Onesorge Miranda Lopes, Ernani Pinto, Larissa Souza Passos, Fabiane Dorr, Christiane Mileib Vasconcelos, Clarisse Arpini, Marli Oliveira Silva, Tatiana Miura Pereira, Gabriel Carvalho Coppo, Julia Mercon, Levy Carvalho Gomes
Summary: This study evaluated the influence of tilapia production in cages on the presence of GSM and MIB in water and sediment. The findings suggest that eutrophication caused by fish farming and inadequate governmental policies lead to off-flavors in fish products.
Article
Chemistry, Applied
Dawei Sun, Chengquan Zhou, Jun Hu, Li Li, Hongbao Ye
Summary: This study investigates the possibility of comprehensive off-flavor profiling in salmonid products using near-infrared hyperspectral imaging and machine learning. Classification models were constructed using different algorithms to identify off-flavor salmonids. The results show that the one-dimensional convolutional neural network achieves the highest discrimination accuracy. The study also demonstrates the potential of near-infrared hyperspectral imaging for off-flavor profiling in salmonid muscle samples.
Article
Agricultural Engineering
Ramsey Kropp, Steven T. Summerfelt, Kyle Woolever, Samuel A. Johnson, David W. Kapsos, Christopher Haughey, Terence P. Barry
Summary: This study aims to evaluate the effects of a novel advanced oxidation process on the removal of off-flavor chemicals in Atlantic salmon aquaculture. The results indicate that the technology can speed up the purging process and save water, leading to positive economic impacts for commercial operators.
AQUACULTURAL ENGINEERING
(2022)
Article
Chemistry, Physical
Vittorio Zorzi, Andrea Bertini, Andrew Robertson, Annachiara Berardinelli, Leonardo Palmisano, Francesco Parrino
Summary: The accumulation of off-flavour compounds such as geosmin (GSM) and 2-methylisoborneol (MIB) in recirculating aquaculture system (RAS) threatens its popularity. Advanced oxidation processes (AOPs) have shown promise in controlling these off-flavours throughout the production cycle. This review highlights the current state of AOPs application to GSM and MIB degradation, emphasizing the advantages of promising coupled processes such as photocatalytic ozonation.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Binbin Gu, Jeroen S. Dickschat
Summary: The biosynthesis of 2-methylisoborneol was investigated by elongating DMAPP with (S)- and (R)-2-Me-IPP using FPPS, followed by terpene cyclization. The stereochemical course of the FPPS reaction was studied in detail using stereoselectively deuterated 2-Me-IPP isotopomers.
CHEMICAL COMMUNICATIONS
(2022)
Article
Environmental Sciences
Mohamed E. Abd El-Hack, Mohamed T. El-Saadony, Ahmed R. Elbestawy, Hany F. Ellakany, Samar S. Abaza, Amr M. Geneedy, Heba M. Salem, Ayman E. Taha, Ayman A. Swelum, Fatima A. Omer, Synan F. AbuQamar, Khaled A. El-Tarabily
Summary: Off-flavours in fish products from recirculating aquaculture systems, caused by geosmin and 2-MIB produced by actinobacteria, myxobacteria, and cyanobacteria, are a significant issue impacting the fish farming industry. These off-flavours deteriorate the quality of fish and require additional costs for removal.
MARINE POLLUTION BULLETIN
(2022)
Article
Environmental Sciences
Nicolas A. Clercin, Gregory K. Druschel, Mark Gray
Summary: Studies have shown differences in the distribution of MIB and GSM in Eagle Creek Reservoir, with MIB more prevalent in the dissolved phase and GSM primarily bound to cells. The analysis identified different potential bacterial degraders for MIB and GSM, highlighting the impact of microbial communities on the biodegradation susceptibility of taste-and-odor compounds.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Agricultural Engineering
John Davidson, Steven Summerfelt, Casey Grimm, Gregory Fischer, Christopher Good
Summary: This study assessed the effects of swimming speed and dissolved oxygen concentration on GSM levels in water and fish flesh during a 10-day depuration period. The results showed that swimming speed and dissolved oxygen concentration did not have a significant impact on the elimination of off-flavors in Atlantic salmon during the depuration process.
AQUACULTURAL ENGINEERING
(2021)
Article
Engineering, Environmental
Jie Yuan, Soroosh Mortazavian, Grace Crowe, Robert Flick, Elodie Passeport, Ron Hofmann
Summary: This study investigated the contributions of adsorption and biodegradation to the removal of MIB and geosmin in GAC harvested from drinking water treatment plants in the Great Lakes region. It was found that GAC had significant adsorption and biodegradation capacity, and C-14-glucose respiration rate was identified as a potential indicator for GAC biodegradative capacity. Non-targeted screening analysis also identified potential biodegradation products. The findings of this study provide valuable insights for better understanding the use of GAC in water treatment.
Article
Fisheries
John Davidson, Natalie Redman, Curtis Crouse, Brian Vinci
Summary: This study characterized water quality and waste production during the depuration process of land-based Atlantic salmon. The results highlight the need for procedural refinements and recommendations such as extending the feed withholding period before depuration.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2023)
Review
Engineering, Environmental
Jie Yuan, Ron Hofmann
Summary: This review critically evaluates the adsorption and biodegradation of MIB and geosmin in GAC filters, and identifies the key factors that affect their removal. The transition from GAC to BAC is complete at 40,000 BV, and an EBCT above 15 min is essential for effective removal of MIB and geosmin.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Fisheries
Shuting Li, Fayi Wei, Xuan Dong, Miaojun Pan, Li Li, Xiangli Tian, Qinfeng Gao, Alan E. Wilson
Summary: This study investigated the factors affecting the abundance of microorganisms that produce off-flavor compounds and the environmental conditions that promote their growth. The concentrations of GSM and MIB in fish varied seasonally, with the highest values in summer. Cyanophyta and Bacillariophyta in water were significantly correlated with GSM and MIB concentrations in fish. Microbial communities were distinct among the seasons, with temperature and phosphorus levels positively correlated with the phyla and genera linked to GSM and MIB concentrations.
Review
Fisheries
Jessica A. Moretto, Paloma N. N. Freitas, Juliana P. Souza, Thalita M. Oliveira, Isabella Brites, Ernani Pinto
Summary: Off-flavors in fish and water are a worldwide problem caused by factors such as phosphorus, micronutrients, and organic matter. Geosmin and 2-methylisoborneol are the most common off-flavors that can accumulate in fish used in aquaculture, affecting the quality, cost, and consumer preference.
Article
Environmental Sciences
Xiaoling Huang, Shuo Wang, Ganxiang Wang, Songming Zhu, Zhangying Ye
Summary: The study evaluated the effectiveness of removing 2-methylisoborneol and geosmin from drinking water using UV-assisted photoelectrochemical method. It was found that a high concentration of electrolyte and acidic solutions can accelerate the removal rate and ratio, while alkaline conditions and impurities have negative effects.
Article
Engineering, Environmental
Snir Azaria, Amos Nussinovitch, Shlomo Nir, Sharon Mordechai, Jaap van Rijn
Summary: Hydrophobic carriers were effective in removing low concentrations of geosmin and 2-methylisoborneol from water in aquaculture systems through a combination of adsorption and biodegradation, with the methods being unaffected by the presence of organic matter. Long-term operation experiments showed that the carriers used for filtration of contaminated water could steadily and efficiently remove geosmin and 2-methylisoborneol.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Review
Rheumatology
Yuki Iizuka, Kaoru Takase-Minegishi, Lisa Hirahara, Yohei Kirino, Yutaro Soejima, Ho Namkoong, Nobuyuki Horita, Ryusuke Yoshimi, Masaki Takeuchi, Mitsuhiro Takeno, Nobuhisa Mizuki, Hideaki Nakajima
Summary: This study evaluated the clinical efficacy of apremilast in treating oral ulcers, extra-oral manifestations, and overall disease activity in patients with Behcet's disease. The results showed that after 12 weeks of treatment, there was a significant improvement in the symptoms of oral ulcers, genital ulcers, erythema nodosum, pseudofolliculitis, and arthritis. Furthermore, the BDCAF scores were significantly reduced. After 24 weeks, the proportion of patients with oral ulcer disappearance increased. These findings suggest that short-term apremilast treatment can improve mucocutaneous and articular symptoms in patients with Behcet's disease.
MODERN RHEUMATOLOGY
(2022)
Article
Oncology
Nobuhiko Fukuda, Nobuyuki Horita, Seigo Katakura, Ho Namkoong, Ayami Kaneko, Kouhei Somekawa, Youichi Tagami, Keisuke Watanabe, Yu Hara, Nobuaki Kobayashi, Takeshi Kaneko
Summary: The study showed that combination therapies of platinum regimen + pembrolizumab and platinum regimen + nivolumab + ipilimumab were more effective than ICI monotherapy for treating squamous NSCLC with low PD-L1 levels.
Article
Medicine, General & Internal
Atsuho Morita, Ho Namkoong, Makoto Hosoya, Naoki Hasegawa
Summary: A 56-year-old woman with pulmonary Mycobacterium avium complex disease developed laryngitis one month after starting inhalation liposomal amikacin. The laryngitis healed immediately after treatment discontinuation and no recurrence occurred even after resuming intermittent inhalation.
CLINICAL CASE REPORTS
(2022)
Article
Rheumatology
Kana Higashitani, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Yohei Kirino, Naoki Hamada, Hideto Nagai, Maki Hagihara, Kenji Matsumoto, Ho Namkoong, Nobuyuki Horita, Hideaki Nakajima
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for systemic sclerosis (SSc), although it is associated with higher treatment-related deaths. However, patients who undergo HSCT have a high survival rate post-transplant.
MODERN RHEUMATOLOGY
(2023)
Article
Infectious Diseases
Atsuho Morita, Ho Namkoong, Kazuma Yagi, Takanori Asakura, Makoto Hosoya, Hiromu Tanaka, Ho Lee, Takunori Ogawa, Tatsuya Kusumoto, Shuhei Azekawa, Kensuke Nakagawara, Hirofumi Kamata, Makoto Ishii, Koichi Fukunaga, Hiroyuki Ozawa, Naoki Hasegawa
Summary: ALIS therapy may be a treatment option for patients with refractory MAC infection with long disease duration and a poor response to guideline-based therapy.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Peripheral Vascular Disease
Shintaro Minegishi, Sho Kinguchi, Nobuyuki Horita, Ho Namkoong, Alexandros Briasoulis, Tomoaki Ishigami, Kouichi Tamura, Akira Nishiyama, Yuichiro Yano
Summary: The initiation of immune checkpoint inhibitors (ICIs) is not associated with an increased short-term risk of hypertension in cancer patients, regardless of concomitant treatment with other anticancer drugs.
Article
Infectious Diseases
Takahiro Fukushima, Shotaro Chubachi, Ho Namkoong, Shiro Otake, Kensuke Nakagawara, Hiromu Tanaka, Ho Lee, Atsuho Morita, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: The study reveals a relationship between abnormal serum uric acid levels or a history of hyperuricemia and the severity of COVID-19, with significant associations observed in the Japanese population cohort.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Rheumatology
Ayaka Maeda, Kaoru Takase-Minegishi, Yohei Kirino, Naoki Hamada, Yosuke Kunishita, Ryusuke Yoshimi, Akira Meguro, Ho Namkoong, Nobuyuki Horita, Hideaki Nakajima
Summary: Arthralgia is the most commonly reported immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs), and it is associated with overall survival (OS).
Article
Infectious Diseases
Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: Through a retrospective cohort study, we found significant differences in the characteristics of hospitalized COVID-19 patients in Japan during different waves, from conventional strains to the Delta variant. Patients in the second and fifth waves had a lower average age compared to other waves.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Mayuko Watase, Katsunori Masaki, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Takahiro Fukushima, Shiro Otake, Kensuke Nakagawara, Tatsuya Kusumoto, Takanori Asakura, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Yoshitaka Oyamada, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Ryuya Edahiro, Hirohito Sano, Yasunori Sato, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: This study examined the impact of smoking exposure and COPD on COVID-19 outcomes among smokers in Japan. The results showed that smoking exposure and COPD are associated with the need for invasive mechanical ventilation in severe COVID-19 cases. Smoking exposure and COPD increase the risk of severe COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Masanori Kaji, Ho Namkoong, Genta Nagao, Shuhei Azekawa, Kensuke Nakagawara, Hiromu Tanaka, Atsuho Morita, Takanori Asakura, Hirofumi Kamata, Yoshifumi Uwamino, Mitsunori Yoshida, Koichi Fukunaga, Naoki Hasegawa
Summary: A 41-year-old immunocompetent woman with bloody sputum was diagnosed with nasopharyngeal M. abscessus infection. Despite the absence of pulmonary infection or sinusitis, the patient responded well to antibiotic therapy and showed negative results on sputum smear and culture.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Hiromu Tanaka, Shotaro Chubachi, Ho Namkoong, Yasunori Sato, Takanori Asakura, Ho Lee, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Yasushi Kondo, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Yuko Kaneko, Naoki Hasegawa, Soichiro Ueda, Mamoru Sasaki, Takehiro Izumo, Minoru Inomata, Naoki Miyazawa, Yasuhiro Kimura, Yusuke Suzuki, Norihiro Harada, Masako Ichikawa, Tohru Takata, Hiroyasu Ishikura, Takashi Yoshiyama, Hiroyuki Kokuto, Koji Murakami, Hirohito Sano, Tetsuya Ueda, Naota Kuwahara, Akiko Fujiwara, Takashi Ogura, Takashi Inoue, Takahiro Asami, Yoshikazu Mutoh, Ichiro Nakachi, Rie Baba, Koichi Nishi, Mayuko Tani, Junko Kagyo, Mizuha Hashiguchi, Tsuyoshi Oguma, Koichiro Asano, Masanori Nishikawa, Hiroki Watanabe, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: This study aimed to determine the effectiveness of baricitinib in COVID-19 patients, investigate its ability to prevent the need for invasive mechanical ventilation, and identify patient subgroups that would benefit from it. The results showed that baricitinib treatment significantly reduced the risk of requiring invasive mechanical ventilation in COVID-19 patients.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Shunsuke Uno, Rei Goto, Kimiko Honda, Sho Uchida, Yoshifumi Uwamino, Ho Namkoong, Ayumi Yoshifuji, Kei Mikita, Yaoko Takano, Morio Matsumoto, Yuko Kitagawa, Naoki Hasegawa
Summary: Universal asymptomatic preoperative SARS-CoV-2 PCR screening is not cost-effective, and the cost-effectiveness mainly depends on the test-positive rate, the frequency of postoperative pulmonary complications, and screening costs.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hiromu Tanaka, Shotaro Chubachi, Takanori Asakura, Ho Namkoong, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Ho Lee, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga
Summary: This study investigated the clinical characteristics and effectiveness of COVID-19 vaccination in patients hospitalized with the Delta and Omicron variant-dominated waves. It was found that patients with Omicron infections had a lower incidence of critical outcomes and COVID-19 vaccination may contribute to preventing respiratory failure.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hiromu Tanaka, Ho Namkoong, Shotaro Chubachi, Shinji Irie, Yoshifumi Uwamino, Ho Lee, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Yukinori Okada, Tomomi Takano, Seiya Imoto, Ryuji Koike, Akinori Kimura, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Taka-Aki Sato, Koichi Fukunaga
Summary: This study investigates the clinical characteristics of patients with COVID-19 who harbor intracellular SARS-CoV-2 RNA. The results show that patients with detectable viral RNA have a more severe disease course compared to those without detectable viral RNA.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)