Review
Nutrition & Dietetics
Masanori Kono, Yasuo Nagafuchi, Hirofumi Shoda, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease primarily affecting women, possibly due to environmental factors and genetic predisposition. Habits of high-fat diet and obesity could be related to the pathogenesis of SLE, with vitamin D and adipokines like leptin potentially playing a role in connecting obesity and SLE.
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Dagmara Kociszewska, Jeffrey Chan, Peter R. Thorne, Srdjan M. Vlajkovic
Summary: This review focuses on the association between gut dysbiosis and hearing loss, highlighting the potential harm of a high-fat diet on auditory health. It suggests that changes in gut microbiota may lead to systemic inflammatory response, compromising the blood-labyrinth barrier permeability in the inner ear, thus inducing cochlear inflammation and hearing deficits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Jiang Chen, Lin-Ling Deng, Xing-Lin Xiao, Shi-Yuan Long, Yuan Deng, Tong Peng, Jie Xie, Xiao-Yu Zhang
Summary: Unhealthy diets rich in fats and/or sugar are considered as the major cause of the obesity epidemic, which leads to a decrease in gut hormone GLP1 levels. The gut microbiota plays a significant role in this process, although the underlying mechanism needs further investigation.
Article
Nutrition & Dietetics
Teresa Vezza, Jose Garrido-Mesa, Patricia Diez-Echave, Laura Hidalgo-Garcia, Antonio J. Ruiz-Malagon, Federico Garcia, Manuel Sanchez, Marta Toral, Miguel Romero, Juan Duarte, Enrique Guillamon, Alberto Banos, Rocio Moron, Julio Galvez, Alba Rodriguez-Nogales, Maria Elena Rodriguez-Cabezas
Summary: The study found that propyl propane thiosulfonate (PTSO) helps reduce weight gain, improve plasma markers, and attenuate obesity-associated inflammation, improving gut barrier integrity.
Article
Immunology
Rong Tan, Huiwei Dong, Zhengshan Chen, Min Jin, Jing Yin, Haibei Li, Danyang Shi, Yifan Shao, Huaran Wang, Tianjiao Chen, Dong Yang, Junwen Li
Summary: Unhealthy dietary habits are associated with increased incidence of chronic diseases, with high-fat and high-fructose diets leading to reduced defecation volume, increased levels of pro-inflammatory cytokines and IgG in serum, inflammatory cell infiltration in intestinal tissue, changes in microbial composition, alterations in microbial metabolites, and potential causes of constipation and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Zheng Zhang, Tao Lin, Yichen Meng, Miao Hu, Lun Shu, Heng Jiang, Rui Gao, Jun Ma, Ce Wang, Xuhui Zhou
Summary: This study revealed that long-term high-fat diet can lead to decreased bone mass, dysbiosis of gut microbiota, leaky gut, and systemic inflammation. Administration of fructooligosaccharides (FOS) and/or galactooligosaccharides (GOS) significantly improved bone loss, regulated imbalanced differentiation of intestinal cells, reduced dysbiosis and gut permeability, decreased expression of inflammatory cytokines, ultimately protecting against high-fat diet-induced osteopenia.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Environmental Sciences
Takuro Okamura, Masahide Hamaguchi, Yuka Hasegawa, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Ryoichi Sasano, Yuki Nakanishi, Hiroshi Seno, Hirohisa Takano, Michiaki Fukui
Summary: The study found that microplastics can cause metabolic disturbances, such as diabetes and nonalcoholic fatty liver disease, in mice on a high-fat diet. The results highlight the importance of reducing oral exposure to microplastics through environmental measures to improve metabolic disturbance under high-fat diet conditions.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Multidisciplinary Sciences
Woongjae Yoo, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, Stephanie A. Cevallos, Erik Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, Jeffrey C. Rathmell, Amy S. Major, Andreas J. Baumler, Mariana X. Byndloss
Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
Article
Pharmacology & Pharmacy
Maria Chiara Valerii, Silvia Turroni, Carla Ferreri, Michela Zaro, Anna Sansone, Alessandro Dalpiaz, Giada Botti, Luca Ferraro, Renato Spigarelli, Irene Bellocchio, Federica D'Amico, Enzo Spisni
Summary: Studies have shown that D-Limonene can improve metabolic parameters in obese mice via various mechanisms, including modulation of intestinal microbiota. Administering a food supplement containing D-Limonene adsorbed on dietary fibers to mice on a high-fat diet led to decreased weight gain and improved metabolic profile, highlighting the potential non-toxic and effective use of this supplement in combating obesity.
Article
Microbiology
Fang Qiao, Fang Tan, Ling-Yu Li, Hong-Bo Lv, Liqiao Chen, Zhen-Yu Du, Mei-Ling Zhang
Summary: This study found that a high-fat diet had a more dominant influence on shaping the composition of gut microbiota to induce lipid accumulation compared to gene-knockouts of cpt1b or pparab. Additionally, RNA-based bacterial sequencing revealed more significant alterations in bacterial composition.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Polymer Science
Jiali Wei, Yiran Zhao, Chen Zhou, Qing Zhao, Hongqian Zhong, Xinyu Zhu, Tianyu Fu, Lin Pan, Qingsen Shang, Guangli Yu
Summary: This study demonstrated the anti-obesity effect of Enteromorpha clathrata polysaccharide (ECP) by reducing body weight and levels of triacylglycerol and cholesterol in high-fat diet (HFD)-fed mice. ECP improved intestinal dysbiosis caused by HFD and reshaped the gut microbiota structure, suggesting its potential as a new prebiotic for treating obesity and associated disorders.
Article
Food Science & Technology
Wei Song, Chen Song, Li Li, Tianyi Wang, Jinhong Hu, Lina Zhu, Tianli Yue
Summary: The study found that three Lactobacillus strains have inhibitory effects on obesity induced by high-fat diet, reducing weight gain and adipose accumulation, while also improving hepatic steatosis. These probiotics also regulated serum lipid levels and adipocytokines, and altered the diversity of gut microbiota.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Microbiology
Z. H. Miao, W. X. Zhou, R. Y. Cheng, H. J. Liang, F. L. Jiang, X. Shen, J. H. Lu, M. Li, F. He
Summary: The study suggests that early exposure to ceftriaxone may worsen the negative impacts of a high-fat diet on host physiology, while orally fed TMC3115 has a protective effect. The crosstalk between the host and their intestinal microbiota in early life seems to play a crucial role in metabolism regulation.
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.