mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

(2018) Shiyu Wang et al.   NUCLEIC ACIDS RESEARCH

The No-go decay system degrades plant mRNAs that contain a long A-stretch in the coding region

(2018) István Szádeczky-Kardoss et al.   PLANT SCIENCE

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

(2018) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay

(2018) Carrie L. Simms et al.   PLoS Genetics

Lost in Translation: Ribosome-Associated mRNA and Protein Quality Controls

(2018) Andrey L. Karamyshev et al.   Frontiers in Genetics

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

(2017) Xue-Hai Liang et al.   MOLECULAR THERAPY

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

(2017) Xue-Hai Liang et al.   NUCLEIC ACIDS RESEARCH

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

(2017) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

(2017) Jeffrey K. Bailey et al.   NUCLEIC ACIDS RESEARCH

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

(2016) Xue-hai Liang et al.   NATURE BIOTECHNOLOGY

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

(2016) Xue-Hai Liang et al.   NUCLEIC ACIDS RESEARCH

RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

(2016) Timothy A. Vickers et al.   PLoS One

Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

(2016) Martino Colombo et al.   RNA

A Universal Code for mRNA Stability?

(2016) Ying-Hsin Chen et al.   TRENDS IN GENETICS

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

(2016) Tarek Hilal et al.   Nature Communications

Development of a Method for Profiling Protein Interactions with LNA-Modified Antisense Oligonucleotides Using Protein Microarrays

(2016) Satoko Kakiuchi-Kiyota et al.   Nucleic Acid Therapeutics

Mutations in the G-domain of Ski7 cause specific dysfunction in non-stop decay

(2016) Wataru Horikawa et al.   Scientific Reports

Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro®): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B

(2015) Richard S. Geary et al.   CLINICAL PHARMACOKINETICS

Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay

(2015) Tomoki T Nomakuchi et al.   NATURE BIOTECHNOLOGY

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

(2015) Søren Lykke-Andersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

(2015) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

(2015) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides

(2014) Amanda J. Ward et al.   NUCLEIC ACIDS RESEARCH

Phosphorothioate oligonucleotides can displaceNEAT1RNA and form nuclear paraspeckle-like structures

(2014) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells

(2014) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches

(2014) Samuel G. Rouleau et al.   NUCLEIC ACIDS RESEARCH

The Hbs1-Dom34 Protein Complex Functions in Non-stop mRNA Decay in Mammalian Cells

(2013) Syuhei Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

(2012) Frank Rigo et al.   Nature Chemical Biology

Structure of the no-go mRNA decay complex Dom34–Hbs1 bound to a stalled 80S ribosome

(2011) Thomas Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Cutting the nonsense: the degradation of PTC-containing mRNAs

(2010) Pamela Nicholson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues

(2010) Punit P. Seth et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure of the Dom34–Hbs1 complex and implications for no-go decay

(2010) Liming Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice

(2010) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of deadenylation-dependent decay

(2010) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

RNA decay modulates gene expression and controls its fidelity

(2010) Shubhendu Ghosh et al.   Wiley Interdisciplinary Reviews-RNA

No-go decay: a quality control mechanism for RNA in translation

(2010) Yuriko Harigaya et al.   Wiley Interdisciplinary Reviews-RNA

Analysis of Dom34 and Its Function in No-Go Decay

(2009) Dario O. Passos et al.   MOLECULAR BIOLOGY OF THE CELL

Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy

(2009) S. A. M. Mulders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA