标题
DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases
作者
关键词
Huntington’s disease, Spinocerebellar ataxia, DNA repair, Oxidative stress, Ataxia telangiectasia-mutated (ATM), Poly ADP-ribose polymerase (PARP)
出版物
Neurotherapeutics
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-31
DOI
10.1007/s13311-019-00768-7
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Treating Disease at the RNA Level with Oligonucleotides
- (2019) Arthur A. Levin NEW ENGLAND JOURNAL OF MEDICINE
- Ataxia‐telangiectasia: A review of clinical features and molecular pathology
- (2019) Parisa Amirifar et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Length of Uninterrupted CAG, Independent of Polyglutamine Size, Results in Increased Somatic Instability, Hastening Onset of Huntington Disease
- (2019) Galen E.B. Wright et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
- (2019) Rui Gao et al. eLife
- FAN1 protects against repeat expansions in a Fragile X mouse model
- (2018) Xiao-Nan Zhao et al. DNA REPAIR
- N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
- (2018) Laura E. Bowie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington’s disease patients
- (2018) Georgina Askeland et al. Scientific Reports
- Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra
- (2018) Venturina Stagni et al. Frontiers in Oncology
- A Patient-Derived Cellular Model for Huntington's Disease Reveals Phenotypes at Clinically Relevant CAG Lengths
- (2018) Claudia Lin-Kar Hung et al. MOLECULAR BIOLOGY OF THE CELL
- DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage
- (2018) Tamara Maiuri et al. DNA AND CELL BIOLOGY
- FAN1 modifies Huntington’s disease progression by stabilising the expanded HTT CAG repeat
- (2018) Robert Goold et al. HUMAN MOLECULAR GENETICS
- Mitochondria as a therapeutic target for common pathologies
- (2018) Michael P. Murphy et al. NATURE REVIEWS DRUG DISCOVERY
- Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
- (2018) Tae-In Kam et al. SCIENCE
- Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies
- (2018) Hasnaa A. Elfawy et al. LIFE SCIENCES
- A modifier of Huntington's disease onset at the MLH1 locus
- (2017) Jong-Min Lee et al. HUMAN MOLECULAR GENETICS
- A comprehensive in silico analysis of huntingtin and its interactome
- (2017) Valentina Brandi et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- (2017) Davina J Hensman Moss et al. LANCET NEUROLOGY
- Neurological disorders associated with DNA strand-break processing enzymes
- (2017) Bingcheng Jiang et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
- (2017) Niyo Kato et al. Cell Reports
- DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases
- (2016) Conceição Bettencourt et al. ANNALS OF NEUROLOGY
- Novel regulators and molecular mechanisms of p53R2 and its disease relevance
- (2016) E.C. Cho et al. BIOCHIMIE
- Furan oxidation based cross-linking: a new approach for the study and targeting of nucleic acid and protein interactions
- (2016) L. L. G. Carrette et al. CHEMICAL COMMUNICATIONS
- PARG Inhibitors and Functional PARG Inhibition Models
- (2016) Yuka Sasaki et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- A polymorphism in the MSH3 mismatch repair gene is associated with the levels of somatic instability of the expanded CTG repeat in the blood DNA of myotonic dystrophy type 1 patients
- (2016) Fernando Morales et al. DNA REPAIR
- Disease-associated repeat instability and mismatch repair
- (2016) Monika H.M. Schmidt et al. DNA REPAIR
- Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization
- (2016) Laura F. DiGiovanni et al. HUMAN MOLECULAR GENETICS
- XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
- (2016) Nicolas C. Hoch et al. NATURE
- Distinct stress conditions result in aggregation of proteins with similar properties
- (2016) Alan J. Weids et al. Scientific Reports
- Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4
- (2015) Jose Bras et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease
- (2015) Jong-Min Lee et al. CELL
- Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
- (2015) Ram Madabhushi et al. CELL
- Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration
- (2015) Michael Fasullo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Protein Quality Control under Oxidative Stress Conditions
- (2015) Jan-Ulrik Dahl et al. JOURNAL OF MOLECULAR BIOLOGY
- Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3
- (2015) Rui Gao et al. PLoS Genetics
- HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice
- (2014) H. Ito et al. EMBO Molecular Medicine
- Interstrand DNA–DNA Cross-Link Formation Between Adenine Residues and Abasic Sites in Duplex DNA
- (2014) Nathan E. Price et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
- (2014) S. A. Andrabi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
- (2014) X.-H. Lu et al. Science Translational Medicine
- A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1
- (2013) Nicholas T. Hertz et al. CELL
- A Synthetic Oligonucleotide Model for Evaluating the Oxidation and Crosslinking Propensities of Natural Furan-Modified DNA
- (2013) Lieselot L. G. Carrette et al. CHEMBIOCHEM
- The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal
- (2013) T. Maiuri et al. HUMAN MOLECULAR GENETICS
- Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
- (2013) Ricardo Mouro Pinto et al. PLoS Genetics
- MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice
- (2013) Stéphanie Tomé et al. PLoS Genetics
- Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice
- (2012) A. Di Pardo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease
- (2011) Guy Keryer et al. JOURNAL OF CLINICAL INVESTIGATION
- Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’
- (2011) Rudy J Castellani et al. JOURNAL OF PATHOLOGY
- Kinase inhibitors modulate huntingtin cell localization and toxicity
- (2011) Randy Singh Atwal et al. Nature Chemical Biology
- Mitochondrial and Nuclear Cross Talk in Cell Death
- (2010) Shaida A. Andrabi et al. Annals of the New York Academy of Sciences
- NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death
- (2010) C. C. Alano et al. JOURNAL OF NEUROSCIENCE
- Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
- (2010) Jun Shen et al. NATURE GENETICS
- Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
- (2010) Juliette D. Godin et al. NEURON
- Regional aerobic glycolysis in the human brain
- (2010) S. Neil Vaishnavi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
- (2009) Qian Cheng et al. EMBO JOURNAL
- Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
- (2009) Meera Swami et al. HUMAN MOLECULAR GENETICS
- Phosphorylation of Threonine 3
- (2009) Charity T. Aiken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Human MutL-complexes monitor homologous recombination independently of mismatch repair
- (2008) Simone Yasmin Siehler et al. DNA REPAIR
- Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
- (2008) Ray Truant et al. FEBS Journal
- DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates
- (2008) Jennifer Illuzzi et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Psoralen-Induced DNA Interstrand Cross-Links Block Transcription and Induce p53 in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner
- (2008) F. A. Derheimer et al. MOLECULAR PHARMACOLOGY
- ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
- (2008) L. Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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