标题
G protein-coupled receptor kinases as therapeutic targets in the heart
作者
关键词
-
出版物
Nature Reviews Cardiology
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-06-11
DOI
10.1038/s41569-019-0220-3
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Adenoviral βARKct Cardiac Gene Transfer Ameliorates Post-resuscitation Myocardial Injury in a Porcine Model of Cardiac Arrest
- (2019) Deya Shang et al. SHOCK
- Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association
- (2018) Emelia J. Benjamin et al. CIRCULATION
- The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
- (2018) Daniela Sorriento et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Various effects of AAV9-mediated βARKct gene therapy in different mouse models of inherited cardiomyopathy
- (2018) Ralf Bauer et al. NEUROMUSCULAR DISORDERS
- Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine
- (2017) Helen V. Waldschmidt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression
- (2017) Joshua G. Travers et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- GRK2 Regulates α 2 -Adrenergic Receptor–Dependent Catecholamine Release in Human Adrenal Chromaffin Cells
- (2017) Alessandro Cannavo et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide SignalingNovelty and Significance
- (2016) David J. Polhemus et al. CIRCULATION RESEARCH
- Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors
- (2016) Helen V. Waldschmidt et al. JOURNAL OF MEDICINAL CHEMISTRY
- G Protein–Coupled Receptor-G–Proteinβγ–Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure
- (2016) Fadia A. Kamal et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells
- (2016) Cheon Ho Park et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells
- (2016) Malika Jafferjee et al. MOLECULAR ENDOCRINOLOGY
- A peptide of the RGS domain of GRK2 binds and inhibits Gαqto suppress pathological cardiac hypertrophy and dysfunction
- (2016) Sarah M. Schumacher et al. Science Signaling
- Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study
- (2016) Yu Li et al. MEDICAL SCIENCE MONITOR
- A peptide of the RGS domain of GRK2 binds and inhibits Gαqto suppress pathological cardiac hypertrophy and dysfunction
- (2016) Sarah M. Schumacher et al. Science Signaling
- Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
- (2016) Hae-Young Lee et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- GPCR signaling and cardiac function
- (2015) Leany A. Capote et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor
- (2015) Kristoff T. Homan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels
- (2015) Priscila Y. Sato et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease
- (2015) Priscila Y. Sato et al. PHYSIOLOGICAL REVIEWS
- Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
- (2015) Sarah M. Schumacher et al. Science Translational Medicine
- Functional role of voltage gated Ca2+ channels in heart automaticity
- (2015) Pietro Mesirca et al. Frontiers in Physiology
- Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors
- (2014) Kristoff T. Homan et al. ACS Chemical Biology
- GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity
- (2014) Jonathan E. Hullmann et al. CIRCULATION RESEARCH
- Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-G βγ Inhibition Halts Heart Failure Progression
- (2014) Fadia A. Kamal et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor
- (2014) Kristoff Homan et al. MOLECULES
- Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors
- (2013) Sung Yun Cho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting
- (2013) Mai Chen et al. CIRCULATION RESEARCH
- Reversal of cardiac dysfunction and subcellular alterations by metoprolol in heart failure due to myocardial infarction
- (2013) Andrea Babick et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process
- (2013) Jessica I. Gold et al. PLoS One
- Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility
- (2012) David M. Thal et al. ACS Chemical Biology
- Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure ethiology and correlates to clinical variables
- (2012) Fermí Montó et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model
- (2012) P. W. J. Raake et al. EUROPEAN HEART JOURNAL
- MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction
- (2012) JaBaris D. Swain et al. Journal of Cardiovascular Translational Research
- Cardiorenal syndrome in heart failure: A cardiologist's perspective
- (2011) Peter P. Liu CANADIAN JOURNAL OF CARDIOLOGY
- Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells
- (2011) Kristy Nguyen et al. Cell Communication and Signaling
- Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes
- (2011) T. Kendall Harden et al. CHEMICAL REVIEWS
- G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia
- (2011) Michele Ciccarelli et al. CIRCULATION
- AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve
- (2011) Michael G. Katz et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Distinct Phosphorylation Sites on the 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of -Arrestin
- (2011) K. N. Nobles et al. Science Signaling
- Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure
- (2010) Giuseppe Rengo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms
- (2010) Henriette Brinks et al. CIRCULATION RESEARCH
- Small Molecule Disruption of Gβγ Signaling Inhibits the Progression of Heart Failure
- (2010) Liam M. Casey et al. CIRCULATION RESEARCH
- Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-κB–Dependent Hypertrophic Gene Expression
- (2010) Daniela Sorriento et al. HYPERTENSION
- Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction
- (2010) Anastasios Lymperopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Contribution of Adenosine A2A and A2B Receptors to Ischemic Coronary Dilation: Role of KV and KATP Channels
- (2010) ZACHARY C BERWICK et al. MICROCIRCULATION
- Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale
- (2010) Beth A. Rose et al. PHYSIOLOGICAL REVIEWS
- Adrenergic Signaling Polymorphisms and Their Impact on Cardiovascular Disease
- (2010) Gerald W. Dorn PHYSIOLOGICAL REVIEWS
- 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation
- (2010) V. O. Nikolaev et al. SCIENCE
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors
- (2009) Wayne C.H. Wang et al. Pharmacogenetics and Genomics
- Pharmacogenomics of β1-Adrenergic Receptor Polymorphisms in Heart Failure
- (2009) Stephen B. Liggett Heart Failure Clinics
- Right ventricular beneficial effects of beta adrenergic receptor kinase inhibitor (βARKct) gene transfer in a rat model of severe pressure overload
- (2008) Ezequiel J. Molina et al. BIOMEDICINE & PHARMACOTHERAPY
- Adenoviral β-Adrenergic Receptor Kinase Inhibitor Gene Transfer Improves Exercise Capacity, Cardiac Contractility, and Systemic Inflammation in a Model of Pressure Overload Hypertrophy
- (2008) Dipin Gupta et al. CARDIOVASCULAR DRUGS AND THERAPY
- Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure
- (2008) Giuseppe Rengo et al. CIRCULATION
- The Carboxyl-terminal PDZ Ligand Motif of Chemokine Receptor CXCR2 Modulates Post-endocytic Sorting and Cellular Chemotaxis
- (2008) Paige J. Baugher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracellular mechanisms of specific β-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure
- (2008) Jan B. Bartholomeu et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Modulation of Adrenal Catecholamine Secretion by In Vivo Gene Transfer and Manipulation of G Protein–coupled Receptor Kinase-2 Activity
- (2008) Anastasios Lymperopoulos et al. MOLECULAR THERAPY
- A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
- (2008) Stephen B Liggett et al. NATURE MEDICINE
- The G-protein-coupled receptor kinase 5 inhibits NF B transcriptional activity by inducing nuclear accumulation of I B
- (2008) D. Sorriento et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro
- (2008) G. Mayer et al. RNA
- Heterotrimeric G protein activation by G-protein-coupled receptors
- (2007) William M. Oldham et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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