Adrenergic Signaling Polymorphisms and Their Impact on Cardiovascular Disease

Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant

(2010) Bas J.M. Peters et al.   Pharmacogenetics and Genomics

Insertion/deletion polymorphism in α2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death

(2009) Jari A. Laukkanen et al.   AMERICAN HEART JOURNAL

G-Protein-Coupled Receptor Kinase 4 Polymorphisms and Blood Pressure Response to Metoprolol Among African Americans: Sex-Specificity and Interactions

(2009) V. Bhatnagar et al.   AMERICAN JOURNAL OF HYPERTENSION

Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors

(2009) Hector R. Mobine et al.   Circulation-Heart Failure

An α 2C -Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the β-Blocker Bucindolol in Chronic Heart Failure

(2009) Michael R. Bristow et al.   Circulation-Heart Failure

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

(2009) Letizia Spinelli et al.   EUROPEAN JOURNAL OF HEART FAILURE

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

(2009) Karol Estrada et al.   HUMAN MOLECULAR GENETICS

Use of Genetics in the Clinical Evaluation of Cardiomyopathy

(2009) Daniel P. Judge   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates β2Adrenoceptor Coupling to GiProteins in Cardiomyocytes

(2009) Ruijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorphisms of Adrenoceptors are Not Associated With an Increased Risk of Adverse Event in Heart Failure: A MERIT-HF Substudy

(2009) Jacqueline Savva et al.   JOURNAL OF CARDIAC FAILURE

Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease

(2009) Scot J. Matkovich et al.   JOURNAL OF CLINICAL INVESTIGATION

GRK mythology: G-protein receptor kinases in cardiovascular disease

(2009) Gerald W. Dorn   JOURNAL OF MOLECULAR MEDICINE-JMM

Clinical and Genetic Modifiers of Long-Term Survival in Heart Failure

(2009) Sharon Cresci et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanisms of Pharmacogenomic Effects of Genetic Variation within the Cardiac Adrenergic Network in Heart Failure

(2009) G. W. Dorn et al.   MOLECULAR PHARMACOLOGY

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Novel pharmacotherapies to abrogate postinfarction ventricular remodeling

(2009) Gerald W. Dorn   Nature Reviews Cardiology

A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of β2-adrenergic receptors

(2009) Wayne C.H. Wang et al.   Pharmacogenetics and Genomics

CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure

(2009) C F Sharp et al.   PHARMACOGENOMICS JOURNAL

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

Association of  1-Adrenergic Receptor Genetic Polymorphism With Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Artery Disease

(2008) M. Hassan et al.   ARCHIVES OF INTERNAL MEDICINE

Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population

(2008) Silvia R Freitas et al.   BMC Cardiovascular Disorders

Multiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival

(2008) Sharon LR Kardia et al.   BMC Medical Genetics

CYP2D6 Phenotype Prediction From Genotype: Which System Is the Best?

(2008) J Kirchheiner   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in β-Blocker Users

(2008) MJ Bijl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of the CYP2D6 Genotype on the Clinical Effects of Metoprolol: A Prospective Longitudinal Study

(2008) T Rau et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans

(2008) Ulrich H. Frey et al.   EUROPEAN HEART JOURNAL

CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction

(2008) Ksenia Goryachkina et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Ile164 variant of β2-adrenoceptor does not influence outcome in heart failure but may interact with β blocker treatment

(2008) Mathew D. Littlejohn et al.   EUROPEAN JOURNAL OF HEART FAILURE

Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci

(2008) Shu-Feng Lei et al.   HUMAN GENETICS

Autoimmune diseases: insights from genome-wide association studies

(2008) G. Lettre et al.   HUMAN MOLECULAR GENETICS

Blood Pressure and Renal Sodium Handling in Relation to Genetic Variation in the DRD1 Promoter and GRK4

(2008) Jan A. Staessen et al.   HYPERTENSION

Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach: The Millennium Genome Project for Hypertension

(2008) Katsuhiko KOHARA et al.   HYPERTENSION RESEARCH

Effects of Ile164 Polymorphism of Beta2-Adrenergic Receptor Gene on Coronary Artery Disease

(2008) Federico Piscione et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol

(2008) Amy J. Sehnert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rgs5 Targeting Leads to Chronic Low Blood Pressure and a Lean Body Habitus

(2008) H. Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

Translating insights from the cancer genome into clinical practice

(2008) Lynda Chin et al.   NATURE

The complete genome of an individual by massively parallel DNA sequencing

(2008) David A. Wheeler et al.   NATURE

A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

(2008) Stephen B Liggett et al.   NATURE MEDICINE

Differential coupling of Arg- and Gly389 polymorphic forms of the β1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs

(2008) Steven M. Swift et al.   PHYSIOLOGICAL GENOMICS

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The G-protein-coupled receptor kinase 5 inhibits NF B transcriptional activity by inducing nuclear accumulation of I B 

(2008) D. Sorriento et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression

(2008) Andre Keren et al.   Nature clinical practice. Cardiovascular medicine

Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning

(2007) Alexander R Lyon et al.   Nature clinical practice. Cardiovascular medicine