Article
Chemistry, Multidisciplinary
Chao He, Luodan Yu, Heliang Yao, Yu Chen, Yongqiang Hao
Summary: A BG@NbSiR scaffold has been developed to effectively treat bone metastasis of breast cancer by activating immune response, suppressing metastases, preventing tumor relapses, and promoting osteogenesis. Single-cell sequencing has been used to identify critical factors responding to this scaffold-based therapy, providing insights into underlying therapeutic mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Ana Marin, Rok Hren, Matija Milanic
Summary: Pulsed photothermal radiometry (PPTR) was used to depth profile bruises with two wavelengths, 532 nm and 1064 nm. The 532 nm wavelength detected moderate changes in the shallow skin layers during bruise development, while the 1064 nm wavelength provided additional information for severe bruises.
Review
Chemistry, Multidisciplinary
Wenqi Wang, Xiaowen He, Mingzhi Du, Chen Xie, Wen Zhou, Wei Huang, Quli Fan
Summary: NIR-II fluorescence imaging using 1,064 nm excitation shows higher tissue penetration depth and resolution compared to NIR-I wavelength excited dyes, leading to broader imaging applications. This review summarizes recent advances in 1,064 nm excited NIR-II fluorescence fluorophores for bioimaging, focusing on small molecule dyes and semiconducting polymers. The improved performance of these dyes has implications for future developments in bioimaging techniques.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Environmental
Yongbo Zhang, Xu He, Yongteng Zhang, Yanping Zhao, Siyu Lu, Yongjun Peng, Ligong Lu, Xianglong Hu, Meixiao Zhan
Summary: This study introduces a novel immunomodulator nanoparticle that targets tumor cell mitochondria, combined with photothermal therapy and immune checkpoint blockade to enhance antitumor immune response, effectively suppressing tumor recurrence and metastasis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Yu Dai, Guansong He, Sheng Long, Xin Li, Li Meng, Peng Wang, Xiaodong Li, Zhijian Yang
Summary: In this study, a synthetic strategy was proposed to achieve excellent linear tunability of Au nanorods' longitudinal surface plasmon resonance (LSPR) peaks from 530 to 1200 nm by simply adjusting the dosage of silver nitrate. The LSPR wavelength of the Au nanorods could be precisely controlled at 1064 nm for maximum photothermal performance, which is crucial for spectral matching in photothermal conversion-assisted laser ignition.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Biomedical
Junjian Shen, Minghui Lin, Mengbin Ding, Ningyue Yu, Chun Yang, Deping Kong, Haitao Sun, Zongyu Xie
Summary: In this study, a novel tumor immunosuppressive microenvironment modulating hydrogel platform was developed for the safe, effective, and durable lung metastasis-inhibiting breast cancer treatment. The platform achieved second NIR-II photothermal therapy combined with immunotherapy, prolonging the accumulation time and preventing premature release of immunotherapeutic agents. The platform elevated intratumoral temperature, induced tumor cell apoptosis, and activated thermal immune response by regulating the immunosuppressive microenvironment.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Quan Cheng, Youliang Tian, Huiping Dang, Changchang Teng, Kai Xie, Dalong Yin, Lifeng Yan
Summary: A NIR-II macromolecular probe (MPAE) with excellent biocompatibility and resistance to self-quenching has been synthesized, showing superior performance in biological imaging.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jiawei Liu, Yanwei Xiong, Yicong Gao, Xingpeng Xu, Kai Chen, Qingming Shen, Wei Huang, Quli Fan, Qi Wang
Summary: This work presents the design of high-performance NIR-II phototheranostic agents using molecular oligomerization and donor engineering strategies. Water-soluble nanoparticles with enhanced optical and thermal properties were prepared and showed promising application in NIR-II imaging-guided in vivo photothermal therapy.
Article
Chemistry, Multidisciplinary
Qin Wang, Yu Wu, Xin Deng, Liping Xiang, Ke Xu, Yongliang Li, Yangsu Xie
Summary: By compositing MoS2 nanoflowers with CNT networks, the bolometric performance of the composite material and the sensitivity of the infrared sensor can be improved.
Article
Engineering, Biomedical
Maoyuan Sun, Yan Li, Wenli Zhang, Xiang Gu, Rong Wen, Ke Zhang, Jinning Mao, Chengyao Huang, Xiong Zhang, Mao Nie, Zhiwen Zhang, Chao Qi, Kaiyong Cai, Guodong Liu
Summary: In this study, a biomimetic nanoplatform AMNP@CLP@CCM was developed for the targeted photothermal therapy and immune checkpoint blockade (ICB) treatment of glioblastoma (GBM). The nanoplatform successfully crossed the blood-brain barrier and delivered the immune checkpoint inhibitor CLP002 to GBM tissues. The photothermal therapy not only enhanced blood-brain barrier penetration but also stimulated immunogenic cell death and T lymphocyte infiltration, resulting in significant growth inhibition of orthotopic GBM.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Qianwen Yu, Xian Tang, Wei Zhao, Yue Qiu, Jiao He, Dandan Wan, Jianping Li, Xuhui Wang, Xuan He, Yayuan Liu, Man Li, Zhirong Zhang, Qin He
Summary: The combination of mild hyperthermia and immune checkpoint blockade treatment effectively suppressed tumor growth and metastasis; size-adjustable nanoparticles have great potential in improving cancer treatment outcomes.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Shanshan Liu, Jiawen He, Ruixiang Song, Mengmeng Zhang, Lianghao Huang, Jing Chen, Meng Wang, Fang Liu, Feifan Zhou
Summary: The study demonstrated a novel treatment strategy combining local photothermal therapy and PD-L1 immunotherapy, which could significantly reduce the growth and metastasis of pancreatic tumors.
Article
Chemistry, Multidisciplinary
Lanxin Mu, Luhe Qi, Haitao Long, Jing Huang, Zibiao Zhong, Xiaowen Shi, Chaoji Chen, Qifa Ye
Summary: A novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, using a photothermal fibrous chitosan/polydopamine sponge, which effectively addresses bleeding and inhibits tumor recurrence and metastasis, offering significant promise for improving liver cancer surgery.
Article
Materials Science, Multidisciplinary
Xingyu Zhao, Yu Han, Yang Sun, Wei Feng, Jianguo Liu, Dongsong Li, Tiejun Wang
Summary: This study developed a multi-approach treatment strategy for osteosarcoma by combining photothermal ablation-based in situ tumor vaccine with PD-1/PD-L1 blockade immunotherapy. The strategy enhances the specific killing effect of T cells on tumor cells by generating in situ tumor vaccine and activating DCs.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Changchang Teng, Huiping Dang, Shangzhong Zhang, Yixuan Xu, Dalong Yin, Lifeng Yan
Summary: In this study, a novel cyanine dye and its nanoparticles were synthesized for high-resolution and deep-tissue imaging as well as phototherapy in the near-infrared IIa window.
ACTA BIOMATERIALIA
(2022)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)