Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy
出版年份 2019 全文链接
标题
Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy
作者
关键词
Mucosal melanoma, Targeted therapy, <em class="EmphasisTypeItalic ">CDK4</em>, <em class="EmphasisTypeItalic ">CCND1</em>, <em class="EmphasisTypeItalic ">P16</em><sup><em class="EmphasisTypeItalic ">INK4a</em></sup>
出版物
Journal of Translational Medicine
Volume 17, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-29
DOI
10.1186/s12967-019-1987-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Synergistic anti-cancer activity of CDK4/6 inhibitor palbociclib and dual mTOR kinase inhibitor MLN0128 in pRb-expressing ER-negative breast cancer
- (2019) Takuro Yamamoto et al. BREAST CANCER RESEARCH AND TREATMENT
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations
- (2019) Rong Zhou et al. CLINICAL CANCER RESEARCH
- A functional landscape of resistance to MEK1/2 and CDK4/6 inhibition in NRAS mutant melanoma
- (2019) Tikvah K Hayes et al. CANCER RESEARCH
- Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer
- (2018) Xia Wang et al. Cancer Prevention Research
- Integrated genomic analyses in PDX model reveal a cyclin-dependent kinase inhibitor Palbociclib as a novel candidate drug for nasopharyngeal carcinoma
- (2018) Cheng-Lung Hsu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Expression of MT4-MMP, EGFR and RB in triple negative breast cancer strongly sensitizes tumors to erlotinib and palbociclib combination therapy
- (2018) Pierre Foidart et al. CLINICAL CANCER RESEARCH
- Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer
- (2018) Ahmed Basudan et al. MOLECULAR CANCER RESEARCH
- CDK4/6 inhibition triggers anti-tumour immunity
- (2017) Shom Goel et al. NATURE
- Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
- (2017) Kosuke Aoki et al. NEURO-ONCOLOGY
- Cancer statistics in China, 2015
- (2016) Wanqing Chen et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Loss ofCDKN2Aexpression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
- (2014) Richard J. Young et al. Pigment Cell & Melanoma Research
- Phase II Randomized Trial Comparing High-Dose IFN- 2b with Temozolomide Plus Cisplatin as Systemic Adjuvant Therapy for Resected Mucosal Melanoma
- (2013) B. Lian et al. CLINICAL CANCER RESEARCH
- The Cell-Cycle Regulator CDK4: An Emerging Therapeutic Target in Melanoma
- (2013) K. E. Sheppard et al. CLINICAL CANCER RESEARCH
- Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma
- (2013) Simon J Furney et al. JOURNAL OF PATHOLOGY
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
- (2012) Michael Krauthammer et al. NATURE GENETICS
- Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
- (2012) Lawrence N Kwong et al. NATURE MEDICINE
- Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases
- (2011) Zhihong Chi et al. BMC CANCER
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Large-Scale Analysis of KIT Aberrations in Chinese Patients with Melanoma
- (2011) Y. Kong et al. CLINICAL CANCER RESEARCH
- Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma
- (2011) A. Ismail et al. CLINICAL CANCER RESEARCH
- Array-Based Comparative Genomic Hybridization Identifies CDK4 and FOXM1 Alterations as Independent Predictors of Survival in Malignant Peripheral Nerve Sheath Tumor
- (2011) J. Yu et al. CLINICAL CANCER RESEARCH
- Prevalence of BRAF V600E mutation in Chinese melanoma patients: Large scale analysis of BRAF and NRAS mutations in a 432-case cohort
- (2011) Lu Si et al. EUROPEAN JOURNAL OF CANCER
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation