Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability

Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis

(2018) Heather L. Caslin et al.   Frontiers in Immunology

Serum lactate is an independent predictor of hospital mortality in critically ill patients in the emergency department: a retrospective study

(2017) Ralphe Bou Chebl et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

(2016) Hiroaki Suzuki et al.   IMMUNOLOGY LETTERS

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-10–Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function

(2016) Amina Abdul Qayum et al.   JOURNAL OF IMMUNOLOGY

Lactic Acid Suppresses IL-33–Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α–Dependent miR-155 Suppression

(2016) Daniel Abebayehu et al.   JOURNAL OF IMMUNOLOGY

Blood Lactate Levels Cutoff and Mortality Prediction in Sepsis—Time for a Reappraisal? a Retrospective Cohort Study

(2016) Roberto Rabello Filho et al.   SHOCK

Early Recognition and Treatment of Sepsis After the Addition of Lactate to the Laboratory’s Critical Result Call List

(2016) Hani I. Kuttab et al.   JOURNAL OF INTENSIVE CARE MEDICINE

The Correlation Between Arterial Lactate and Venous Lactate in Patients With Sepsis and Septic Shock

(2016) Pongdhep Theerawit et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Varying Estimates of Sepsis Mortality Using Death Certificates and Administrative Codes — United States, 1999–2014

(2016) Lauren Epstein et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

(2016) Agustina Errea et al.   PLoS One

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages

(2015) Christina Doxaki et al.   JOURNAL OF IMMUNOLOGY

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages

(2014) Zheng Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cell IL-6 Improves Survival from Klebsiella Pneumonia and Sepsis by Enhancing Neutrophil Killing

(2014) R. E. Sutherland et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Mechanisms Regulating Endothelial Permeability

(2014) Sukriti Sukriti et al.   Pulmonary Circulation

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

(2013) W Y Sanchez et al.   BRITISH JOURNAL OF CANCER

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages

(2013) Stanley F. Fernandez et al.   Biomed Research International

Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study

(2013) Philippe Marty et al.   Annals of Intensive Care

The Chymase Mouse Mast Cell Protease 4 Degrades TNF, Limits Inflammation, and Promotes Survival in a Model of Sepsis

(2012) Adrian M. Piliponsky et al.   AMERICAN JOURNAL OF PATHOLOGY

The lactate conundrum in wound healing: Clinical and experimental findings indicate the requirement for a rapid point-of-care diagnostic

(2012) Stephen Britland et al.   BIOTECHNOLOGY PROGRESS

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes

(2012) Greg S Martin   Expert Review of Anti-Infective Therapy

The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti-Inflammatory Response, and Regulatory T Cells

(2012) D.H. Lewis et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Normal-Range Blood Lactate Concentration in Septic Shock Is Prognostic and Predictive

(2012) Petch Wacharasint et al.   SHOCK

TLR signaling in mast cells: common and unique features

(2012) Hilary Sandig et al.   Frontiers in Immunology

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

(2011) Kristina Goetze   INTERNATIONAL JOURNAL OF ONCOLOGY

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice

(2011) Eric J. Seeley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review

(2011) Ole Kruse et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings

(2010) M. Löffler et al.   DIABETIC MEDICINE

Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice

(2010) Tiago C. Leite et al.   FEBS LETTERS

Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis TherapyA Randomized Clinical Trial

(2010) Alan E. Jones   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock*

(2009) Mark E. Mikkelsen et al.   CRITICAL CARE MEDICINE

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

TLR2-dependent mast cell activation contributes to the control of Mycobacterium tuberculosis infection

(2009) Daniela Carlos et al.   MICROBES AND INFECTION

MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS

(2009) Ryan C. Arnold et al.   SHOCK

Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans

(2008) Friedhelm Sayk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Lactate: physiology and clinical utility

(2008) Sarah E. Allen et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE