Article
Engineering, Biomedical
Hyunjoo Jim, Seung Ho Lee, Adam Wentworth, Sahab Babaee, Kaitlyn Wong, Joy E. Collins, Jacqueline Chu, Keiko Ishida, Johannes Kuosmanen, Joshua Jenkins, Kaitlyn Hess, Aaron Lopes, Joshua Morimoto, Qianqian Wan, Shaunak V. Potdar, Ronan McNally, Caitlynn Tov, Na Yoon Kim, Alison Hayward, Daniel Wollin, Robert Langer, Giovanni Traverso
Summary: The study introduces a novel biodegradable intravesical device for long-term local drug delivery without retrieval procedure, composed of polycaprolactone microcapsules connected with magnets. It can be inserted into the bladder to release drugs, potentially offering cost-effectiveness.
Article
Materials Science, Multidisciplinary
Xinyi Li, Mengjie Ye, Yong-E. Gao, Shengxin Hou, Peng Jia, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: Nanoparticle-based theranostics have become a preferential technology for the diagnosis and treatment of diseases. This study introduces a drug delivery system based on natural silk fibroin (SF NPs). It has been evaluated and found to have high stability, universal drug delivery ability, and good biosafety both in vitro and in vivo.
ADVANCED FIBER MATERIALS
(2022)
Article
Chemistry, Medicinal
Quanling Guo, Lu Zhang, Mengmeng He, Xiaohua Jiang, Jingrui Tian, Qiurong Li, Zhiwei Liu, Longgang Wang, Haotian Sun
Summary: A method utilizing amphipathic and natural antibacterial peptide daptomycin to stabilize doxorubicin and form zwitterionic nanodrug showed promising targeting and anti-tumor effects in experiments, with higher cytotoxicity and tumor inhibition rate than free doxorubicin. The biocompatible daptomycin-based drug delivery system selectively accumulated at tumor sites in vivo through EPR effect, reducing toxicity and achieving excellent tumor inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ya Huang, Hu Li, Tianli Hu, Jian Li, Chun Ki Yiu, Jingkun Zhou, Jiyu Li, Xingcan Huang, Kuanming Yao, Xiao Qiu, Yu Zhou, Dengfeng Li, Binbin Zhang, Rui Shi, Yiming Liu, Tsz Hung Wong, Mengge Wu, Huiling Jia, Zhan Gao, Zhibiao Zhang, Jiahui He, Mengjia Zheng, Enming Song, Lidai Wang, Chenjie Xu, Xinge Yu
Summary: This article reports on a combined treatment using medication and electro-stimulation, which is activated wirelessly and allows for sustained drug delivery, enhancing skeletal muscle regeneration.
Article
Chemistry, Multidisciplinary
Jae Hoon Lee, Jun Su Im, Xuanjun Jin, Tae Min Kim, Joon Weon Choi
Summary: Kraft lignin was successfully utilized as a polymer for drug-encapsulated nanoparticle synthesis, demonstrating high biocompatibility in both in vitro and in vivo tests. This lignin-based drug delivery system shows great potential as an eco-friendly and economically sustainable option for drug delivery.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Noehyun Myung, Seokha Jin, Hyung Joon Cho, Hyun-Wook Kang
Summary: Three-dimensional printing allows for precise and on-demand manufacture of customizable drug delivery systems, but challenges remain in achieving personalized drug delivery that fits a patient-specific drug dosing schedule. The developed user-designed implantable therapeutic device enables personalized drug release kinetics through programming of inner structural design on a microscale.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Rong-Qin Qi, Wei Liu, Duan-Yu Wang, Fan-Qing Meng, Hong-Ying Wang, Hai-Yan Qi
Summary: The study developed a novel nano scaffold for sustainable distribution and controlled release of local anesthetic drug Ropivacaine, which can be activated by ultrasound for drug release. Results showed that the nanostructure exhibited a more controlled drug release profile. Cell compatibility and animal model studies demonstrated improved neuron cell survival rates and pain relief effects with this nano scaffold.
Article
Pharmacology & Pharmacy
Han Bi Ji, Jae Young Hong, Cho Rim Kim, Chang Hee Min, Jae Hoon Han, Min Ji Kim, Se-Na Kim, Cheol Lee, Young Bin Choy
Summary: In this study, an implantable drug-delivery chip (DDC) was developed for prolonged and controlled delivery of systemic drugs. The DDC contained microchannels and drug reservoirs, serving as a diffusion barrier and depot for the drugs. Dual drugs, diclofenac (DF) for systemic exposure and tranilast (TR) for local delivery, were used in the DDC to minimize fibrotic tissue formation. The results showed that the Dual_DDC successfully achieved sustained release of DF and TR, reducing the hindrance in systemic exposure and decreasing fibrotic tissue formation.
Article
Chemistry, Physical
Xiaoyue Qi, Qizhe Chen, Ziyong Chang, Yulin Deng
Summary: By using a pH-sensitive zeolitic imidazolate framework (ZIF)-8, we developed a simple method to increase the porosity of metal-organic frameworks (MOFs) and achieve customized and controllable pore size. Bioetching in an acidic microenvironment during biocatalysis produced stable large mesopores suitable for enzyme loading with retained activity.
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Article
Biotechnology & Applied Microbiology
Tomasz Deptuch, Anna Florczak, Anna Lewandowska, Ewa Leporowska, Karolina Penderecka, Andrzej Marszalek, Andrzej Mackiewicz, Hanna Dams-Kozlowska
Summary: This study evaluated the potential toxicity of systemically administered silk nanospheres by intravenously injecting silk nanoparticles into mice. The results showed no observed toxicity, indicating the potential application of these nanospheres in biomedicine.
Article
Chemistry, Medicinal
Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel, Abdulaziz Mohsen Al-mahallawi
Summary: The study successfully formulated VRC into ternary micellar systems (TMSs) for the topical treatment of ocular mycosis, which showed high solubilization efficiency and small micellar size. After various tests, it exhibited good stability and safety for ocular use, indicating that it can be a promising treatment for ocular mycosis.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Neta Kutner, Konda Reddy Kunduru, Luna Rizik, Shady Farah
Summary: The article discusses recent advances in improving the functionality, biocompatibility, and longevity of implantable medical devices and DDSs. These technologies are expected to enhance the quality of existing implants and deliverable entities while driving the development of new therapy technologies.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Cho Rim Kim, Yong Chan Cho, Seung Ho Lee, Jae Hoon Han, Min Ji Kim, Han Bi Ji, Se-Na Kim, Chang Hee Min, Byung Ho Shin, Cheol Lee, Young Min Cho, Young Bin Choy
Summary: This study developed a fully implantable device for on-demand administration of self-injection drugs via noninvasive manual button clicks on the outer skin. The device allows for accurate and reproducible drug infusion, and prevents unwanted drug leakage.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Sanghun Lee, Sehyeon Park, Junggeon Park, Jae Young Lee
Summary: We developed implantable bioelectrodes with high performance and high biocompatibility by actively modulating the inflammatory response of macrophages. The immobilization of anti-inflammatory cytokine IL-4 on the electrodes successfully induced anti-inflammatory polarization of macrophages, both in vitro and in vivo. These IL-4-immobilized bioelectrodes not only mitigated scarring around the implanted electrodes but also maintained high sensitivity electrocardiogram signals for up to 15 days post-implantation.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Ying Fang, Na Qiao, Heli Deng, Meng Ren, Yufan Zhang, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: Transdermal drug delivery system (TDDS) is effective in alleviating patient's pain and reduces frequent administration. Realizing tunable drug release on fibers/fabrics is important for constructing TDDS platform with good skin affinity and long-term comfortability.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Applied
Jiahui Su, Luyu Zhang, Caichao Wan, Zhijie Deng, Song Wei, Ken-Tye Yong, Yiqiang Wu
Summary: A nature-inspired strategy is developed to create dual-network hydrogels with high self-healing ability and high gauge factor. The hydrogels also have the potential for wastewater purification.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Environmental
Yihang Jiang, Wei Zhu, Zhourui Xu, Zhijun Zhang, Shuo Tang, Miaozhuang Fan, Zhengzheng Li, Jianyu Zhang, Chengbin Yang, Wing-Cheung Law, Ken-Tye Yong, Dong Wang, Gaixia Xu, Ben Zhong Tang
Summary: This study proposes a mitochondrion-targeting two-photon photodynamic therapy (TP-PDT) strategy based on a new type of photosensitizer with aggregation-induced emission (AIE) characteristics. It achieves efficient anti-tumor treatment in hypoxic-tolerant tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Tianxun Gong, Chandreyee Manas Das, Ming-Jie Yin, Tian-Run Lv, Nishtha Manish Singh, Alana M. Soehartono, Gurvinder Singh, Quan-Fu An, Ken-Tye Yong
Summary: Recent advances in surface-enhanced Raman scattering (SERS) have led to the development of SERS tags, which offer significant promise for sensitive and selective detection in medical applications. These tags utilize electromagnetic and chemical enhancement mechanisms to amplify signals, providing high sensitivity, low detection limits, and good selectivity.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Arman Ahnood, Andre Chambers, Amy Gelmi, Ken-Tye Yong, Omid Kavehei
Summary: The advent of electronic technology for neural interfacing in the past 50 years has transformed medicine and biology. Devices like deep brain stimulators and cochlear implants have revolutionized the treatment of previously untreatable conditions. Semiconducting electrodes have advanced neural interfacing technologies, enabling high precision sensing and stimulation in electrical, biochemical, and optical domains. This emerging class of electrodes offers new opportunities for research and treatment.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Yue Zhang, Jiahui Zhou, Heli Deng, Ying Fang, Na Qiao, Meng Ren, Yufan Zhang, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: Researchers have developed a fiber-based membrane with Janus wettability using alternating electrospinning-electrospraying technology, which can resist air pollution and inhibit bacteria proliferation. The membrane consists of silk fibroin nanofibers-substrate, polyurethane nanospheres-top layer, and in-situ grown silver nanoparticles middle layer, providing a self-cleaning physical barrier and a bio-barrier for sterilization. The membrane also has a high PM2.5 filtration efficiency of approximately 98.1%.
JOURNAL OF MATERIALS RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Shuo Li, Weiyao Han, Quan-Fu An, Ken-Tye Yong, Ming-Jie Yin
Summary: Metal-organic frameworks (MOFs) have great potential for membrane-based gas separation applications due to their unique properties. Defect engineering of MOFs has opened up new possibilities for enhancing membrane separation but more research is needed to fully understand its effects. This summary discusses recent developments in defect engineering of MOF-based membranes and outlines the challenges and future prospects in this field.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Yan Guo, Xianglong Su, Kaihua Wu, Ken-Tye Yong
Summary: In this study, a biosensor based on surface plasmon resonance (SPR) technique and nanodisk array was developed to enhance the sensitivity of virus detection. Through systematic optimization of all parameters, four optimal sensing configurations were achieved, leading to improved sensor performance and a smaller detection limit compared to bare gold-based sensors. The optimized sensors can clearly distinguish multi-jump resonance angle curves at tiny refractive index, which is important for accurate detection of trace substances.
Review
Chemistry, Multidisciplinary
Tian-Run Lv, Wen-Hai Zhang, Ya-Qiong Yang, Jia-Chen Zhang, Ming-Jie Yin, Zhigang Yin, Ken-Tye Yong, Quan-Fu An
Summary: With increasing demands for flexible organic electronic devices, conductive polymers have shown significant breakthroughs in the past decade due to their outstanding conductivity, solution-processing ability, and tailorability. However, commercialization of these devices still lags behind due to performance limitations and limited manufacturing techniques. This review comprehensively summarizes the state-of-the-art technologies for developing organic devices using conductive polymers, including synthesis methods, film fabrication techniques, nanostructure and microstructure tailoring, device applications, and future directions.
Article
Materials Science, Multidisciplinary
Miaozhuang Fan, Gang Feng, Lu Xia, Yibin Zhang, Maixian Liu, Zhengzheng Li, Yihang Jiang, Chengbin Yang, Wing-Cheung Law, Ken-Tye Yong, Yuanyuan Shen, Zhourui Xu, Gaixia Xu
Summary: Aggregation-induced emission luminogens (AIEgens) have gained significant attention in the research community as a new class of optical probes for two-photon imaging (2PI). However, their non-radiative energy dissipation affects their performance in 2PI. To address this, an organic doping method using TPE-Br and MeOTTMN is proposed, resulting in enhanced brightness but increased production of reactive oxygen species. The heavily organic-doped AIEgen (ODA) nanoparticles (NPs) enable ultradeep imaging depth of 1000 μm in a mouse brain, surpassing MeOTTMN NPs' imaging depth of 156 μm. The safety of ODA NPs is evaluated through toxicity assessment, providing a promising approach to control energy relaxation of AIEgen NPs in 2PI.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yibin Zhang, Miaozhuang Fan, Zhourui Xu, Yihang Jiang, Huijun Ding, Zhengzheng Li, Kaixin Shu, Mingyan Zhao, Gang Feng, Ken-Tye Yong, Biqin Dong, Wei Zhu, Gaixia Xu
Summary: In this study, machine learning techniques were used to screen AIEgens with desired excitation and emission wavelength for biomedical fluorescence imaging. A database of various AIEgens was established and ML models were trained to predict molecular absorption and emission wavelength peaks. Three newly predicted AIEgens were successfully synthesized and applied for cellular fluorescence imaging and deep penetration imaging, demonstrating the great potential of ML in screening AIEgens with suitable wavelengths for novel organic fluorescent materials.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Hossein Moeinzadeh, Poogitha Jegakumaran, Ken-Tye Yong, Anusha Withana
Summary: Water quality is primarily assessed based on its visual acceptability, and this study proposes a deep learning-based approach to reconstruct seven heavy metal parameters from four parameters in order to estimate the water quality index. The proposed model effectively reconstructs these parameters with high accuracy and reliability, offering a cost-effective solution for understanding water quality.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Cheng Zhou, Geraldine W. N. Chia, Ken-Tye Yong
Summary: By mimicking the structure of lipid bilayers, membrane-intercalating conjugated oligoelectrolytes (MICOEs) have the ability to spontaneously insert themselves into both synthetic lipid bilayers and biological membranes. The modular design of MICOEs allows for a wide range of applications in bioproduction, biocatalysis, biosensing, and therapeutics. This review provides insights into the structural evolution and molecular design principles of MICOEs, as well as discussing their potential as unconventional and value-added materials for biological systems.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Lixing Kang, Yan Zhang, Qian Gong, Chandreyee Manas Das, Huilin Shao, Daniel Puiu Poenar, Philippe Coquet, Ken-Tye Yong
Summary: This study presents the fabrication, testing, and performance of a plasmonic sensor using a gold nanohole array chip coated with WS2 for protein-protein interaction detection. The monoatomic layer deposition of WS2 and its functionalization significantly improved the sensor's performance, enhancing the limit of detection.
Proceedings Paper
Automation & Control Systems
Ziyao Zhang, Maria Sabrina Ma, Jason K. Eshraghian, Daniele Vigolo, Ken-Tye Yong, Omid Kavehei
Summary: Cell sorting and counting technology has been widely used in medical diagnosis, cell-based therapy, and biological research. This article discusses the challenges and limitations of traditional microscopy in capturing cell motion, and proposes the use of neural networks and event-based cameras to overcome these limitations and improve cell sorting and tracking. The authors envision a new type of high-throughput and automated image analysis system and screening instrument.
2022 8TH INTERNATIONAL CONFERENCE ON EVENT-BASED CONTROL, COMMUNICATION AND SIGNAL PROCESSING (EBCCSP 2022)
(2022)
