Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis

Epithelial origin of eosinophilic esophagitis

(2018) Mark Rochman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Solute carrier family 9, subfamily A, member 3 (SLC9A3) /sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis

(2018) Chang Zeng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March

(2018) David A. Hill et al.   Journal of Allergy and Clinical Immunology-In Practice

A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions

(2018) Benjamin F. Sallis et al.   Frontiers in Immunology

Comparison of mucosal impedance measurements throughout the esophagus and mucosal eosinophil counts in endoscopic biopsy specimens in eosinophilic esophagitis

(2018) Jeffrey A. Alexander et al.   GASTROINTESTINAL ENDOSCOPY

Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro : An involvement of Shh pathway

(2017) Haihua Zhang et al.   LIFE SCIENCES

TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis

(2017) N Nguyen et al.   Mucosal Immunology

Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD

(2016) Xiaofang Huo et al.   GUT

Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro

(2015) XIAOYANG MA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing

(2015) Reinhard Depping et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

(2015) Bejan J. Saeedi et al.   MOLECULAR BIOLOGY OF THE CELL

Eosinophilic Esophagitis

(2015) Glenn T. Furuta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Topical Steroids on Tight Junction Proteins and Spongiosis in Esophageal Epithelia of Patients With Eosinophilic Esophagitis

(2014) David A. Katzka et al.   Clinical Gastroenterology and Hepatology

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomes

(2014) Kelley E Capocelli et al.   JOURNAL OF CLINICAL PATHOLOGY

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

(2014) Leah C Kottyan et al.   NATURE GENETICS

Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

(2014) Andrew S. Zimmermann et al.   PLoS One

Alterations in junctional proteins, inflammatory mediators and extracellular matrix molecules in eosinophilic esophagitis

(2013) Solange M. Abdulnour-Nakhoul et al.   CLINICAL IMMUNOLOGY

DMOG Ameliorates IFN-γ-Induced Intestinal Barrier Dysfunction by Suppressing PHD2-Dependent HIF-1α Degradation

(2013) Wen-Sheng Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Epidermal Deletion of HIF-2α Stimulates Wound Closure

(2013) Andrew S. Cowburn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis

(2013) J D Sherrill et al.   Mucosal Immunology

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro

(2013) Eleonora Victoria Charlotta Björkman et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

(2012) Joanne C Masterson et al.   GUT

Eosinophilic esophagitis: Updated consensus recommendations for children and adults

(2011) Chris A. Liacouras et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1  and 2 

(2011) Q. Lin et al.   MOLECULAR CANCER RESEARCH

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-mediated control of HIF/ARNT machinery in epidermal keratinocytes

(2010) Lynda Weir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis

(2010) C. Blanchard et al.   JOURNAL OF IMMUNOLOGY

Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1α heterozygous-null mice after burn wounding

(2010) Xianjie Zhang et al.   WOUND REPAIR AND REGENERATION

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis

(2009) James J. Lee et al.   CARCINOGENESIS