Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

(2019) Jean C. Cruz Hernández et al.   NATURE NEUROSCIENCE

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

(2018) Norman R. Saunders et al.   JOURNAL OF PHYSIOLOGY-LONDON

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

(2018) Changsi Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Global Burden of Stroke

(2018) Mira Katan et al.   SEMINARS IN NEUROLOGY

Effects of Hypoperfusion in Alzheimer's Disease

(2018) Benjamin P. Austin et al.   JOURNAL OF ALZHEIMERS DISEASE

Basement membrane and stroke

(2018) Yao Yao   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior

(2018) Raleigh M. Linville et al.   BIOMATERIALS

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

(2017) Stefano Tarantini et al.   EXPERIMENTAL GERONTOLOGY

Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise

(2017) Robert H Cudmore et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy

(2017) Erlen Lugo-Hernandez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Response of the cerebral vasculature following traumatic brain injury

(2017) Arjang Salehi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

(2017) E. F. Goodall et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Traumatic brain injury results in acute rarefication of the vascular network

(2017) Andre Obenaus et al.   Scientific Reports

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

(2017) Alba Di Pardo et al.   Scientific Reports

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

(2017) Kjeld Møllgård et al.   Scientific Reports

Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease

(2016) Seth Love et al.   BRAIN PATHOLOGY

Cerebral Vascular Injury in Traumatic Brain Injury

(2016) Kimbra Kenney et al.   EXPERIMENTAL NEUROLOGY

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Vascular endothelial growth factor: a neurovascular target in neurological diseases

(2016) Christian Lange et al.   Nature Reviews Neurology

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Exercise, cognitive function, and aging

(2015) Jill N. Barnes   ADVANCES IN PHYSIOLOGY EDUCATION

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

(2015) Sana Suri et al.   Alzheimers & Dementia

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Aberrant astrocytes impair vascular reactivity in Huntington disease

(2015) Han-Yun Hsiao et al.   ANNALS OF NEUROLOGY

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer’s disease and vascular dementia

(2015) Taya Thomas et al.   BRAIN

Matrix metalloproteinases as therapeutic targets for stroke

(2015) Yi Yang et al.   BRAIN RESEARCH

Rapid Modulation of Protein Expression in the Rat Hippocampus Following Deep Brain Stimulation of the Fornix

(2015) Elise Gondard et al.   Brain Stimulation

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice

(2015) Stefano Tarantini et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

(2015) Xing-Lin Tan et al.   Molecular Neurodegeneration

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease

(2015) Ilse S. Pienaar et al.   NEUROBIOLOGY OF DISEASE

Increased CSF biomarkers of angiogenesis in Parkinson disease

(2015) Shorena Janelidze et al.   NEUROLOGY

Wiring the Vascular Network with Neural Cues: A CNS Perspective

(2015) Thomas Wälchli et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Poststroke Angiogenesis, Con: Dark Side of Angiogenesis

(2015) J. Adamczak et al.   STROKE

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Autoregulated paracellular clearance of amyloid-  across the blood-brain barrier

(2015) J. Keaney et al.   Science Advances

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain

(2014) Vincent Y. Ma et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Capillary Transit Time Heterogeneity and Flow-Metabolism Coupling after Traumatic Brain Injury

(2014) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prognostic significance of blood-brain barrier disruption in patients with severe nonpenetrating traumatic brain injury requiring decompressive craniectomy

(2014) Kwok M. Ho et al.   JOURNAL OF NEUROSURGERY

Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex

(2014) Baptiste Lacoste et al.   NEURON

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

(2014) Norman R. Saunders et al.   Frontiers in Neuroscience

The effects of hypertension on the cerebral circulation

(2013) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neurovascular abnormalities in humans and mice with Huntington's disease

(2013) Chien-Yuan Lin et al.   EXPERIMENTAL NEUROLOGY

Regional variations in vascular density correlate with resting-state and task-evoked blood oxygen level-dependent signal amplitude

(2013) Nicolas Vigneau-Roy et al.   HUMAN BRAIN MAPPING

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Neurovascular coupling in normal aging: A combined optical, ERP and fMRI study

(2013) Monica Fabiani et al.   NEUROIMAGE

Traumatic brain injury may be an independent risk factor for stroke

(2013) J. F. Burke et al.   NEUROLOGY

Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials

(2013) Jialing Liu et al.   PROGRESS IN NEUROBIOLOGY

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice

(2012) Thom P. Santisakultarm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular Degeneration in Parkinson's Disease

(2012) Jian Guan et al.   BRAIN PATHOLOGY

Effects of Aging on Angiogenesis

(2012) Johanna Lähteenvuo et al.   CIRCULATION RESEARCH

In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death

(2012) Roa Harb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Energy Metabolism and Blood Flow Differences in Healthy Aging

(2012) Joel Aanerud et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

R6/2 Huntington's Disease Mice Develop Early and Progressive Abnormal Brain Metabolism and Seizures

(2012) E. Cepeda-Prado et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

(2012) Andy Y Shih et al.   NATURE NEUROSCIENCE

A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism

(2012) Nicholas P. Blockley et al.   NMR IN BIOMEDICINE

Passage of parasites across the blood-brain barrier

(2012) Willias Masocha et al.   Virulence

Cellular Mechanisms of Neurovascular Damage and Repair After Stroke

(2011) Ken Arai et al.   JOURNAL OF CHILD NEUROLOGY

Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

(2011) Brinda Desai Bradaric et al.   JOURNAL OF NEURAL TRANSMISSION

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Brain regional angiogenic potential at the neurovascular unit during normal aging

(2011) Nivetha Murugesan et al.   NEUROBIOLOGY OF AGING

Complex relationships between cerebral blood flow and brain atrophy in early Huntington's disease

(2011) J. Jean Chen et al.   NEUROIMAGE

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Scaling of Brain Metabolism and Blood Flow in Relation to Capillary and Neural Scaling

(2011) Jan Karbowski   PLoS One

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Age-associated reductions in cerebral blood flow are independent from regional atrophy

(2010) J. Jean Chen et al.   NEUROIMAGE

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor

(2010) Kristel Knaepen et al.   SPORTS MEDICINE

Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain

(2009) Peter J. Clark et al.   HIPPOCAMPUS

Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis

(2009) Karin Van der Borght et al.   HIPPOCAMPUS

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Implications of Vascular Endothelial Growth Factor for Postischemic Neurovascular Remodeling

(2009) Dirk Matthias Hermann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evidence of angiogenic vessels in Alzheimer’s disease

(2009) Brinda S. Desai et al.   JOURNAL OF NEURAL TRANSMISSION

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Brain Response to Vascular Endothelial Growth Factor-Mediated Angiogenesis and Neurogenesis in Aged Mice

(2009) Peng Gao et al.   STROKE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Exercise and the brain: something to chew on

(2009) Henriette van Praag   TRENDS IN NEUROSCIENCES

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Endothelin-1, aging and hypertension

(2008) Brian L Stauffer et al.   CURRENT OPINION IN CARDIOLOGY

Inflammatory Cytokines in Acute Ischemic Stroke

(2008) Antonino Tuttolomondo et al.   CURRENT PHARMACEUTICAL DESIGN

An Analysis of Regional Microvascular Loss and Recovery following Two Grades of Fluid Percussion Trauma: A Role for Hypoxia-Inducible Factors in Traumatic Brain Injury

(2008) Eugene Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing

(2008) Philip N. Ainslie et al.   JOURNAL OF PHYSIOLOGY-LONDON

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Be smart, exercise your heart: exercise effects on brain and cognition

(2007) Charles H. Hillman et al.   NATURE REVIEWS NEUROSCIENCE