Characterization of Krt19 CreERT allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc

Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy

(2019) J. Wong et al.   OSTEOARTHRITIS AND CARTILAGE

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

(2019) Emanuel J. Novais et al.   MATRIX BIOLOGY

Characterization of Cre recombinase  mouse lines enabling cell type-specific targeting of postnatal intervertebral discs

(2019) Yixin Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aging of mouse intervertebral disc and association with back pain

(2019) Kathleen Vincent et al.   BONE

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration

(2018) Oscar Alvarez-Garcia et al.   AGING CELL

Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration

(2018) Yixin Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

What low back pain is and why we need to pay attention

(2018) Jan Hartvigsen et al.   LANCET

Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus

(2018) Keishi Kishimoto et al.   Nature Communications

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

(2018) Marketa Kaucka et al.   eLife

Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs

(2018) Raffaella Bonavita et al.   Biology Open

Runx2 is required for postnatal intervertebral disc tissue growth and development

(2018) Lifan Liao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

(2017) Aleksander D Szymaniak et al.   eLife

SHH-Dependent Knockout of HIF-1 Alpha Accelerates the Degenerative Process in Mouse Intervertebral Disc

(2017) W-J. Wu et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

US Spending on Personal Health Care and Public Health, 1996-2013

(2016) Joseph L. Dieleman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Col2-Cre and tamoxifen-inducible Col2-CreER target different cell populations in the knee joint

(2016) M. Nagao et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus

(2016) Jake Bedore et al.   Journal of Cell Communication and Signaling

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition

(2015) Christopher J L Murray et al.   LANCET

Understanding Nucleus Pulposus Cell Phenotype: A Prerequisite for Stem Cell Based Therapies to Treat Intervertebral Disc Degeneration

(2015) Hyowon Choi et al.   Current Stem Cell Research & Therapy

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Wnt Signaling Activates Shh Signaling in Early Postnatal Intervertebral Discs, and Re-Activates Shh Signaling in Old Discs in the Mouse

(2014) Tamara Winkler et al.   PLoS One

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

(2014) Christophe Merceron et al.   PLoS One

Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape

(2014) R. S. Kadzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk

(2014) Giovanni Zito et al.   Nature Communications

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Generation and characterization ofScxCretransgenic mice

(2013) Yuki Sugimoto et al.   GENESIS

Loss of β-Catenin Induces Multifocal Periosteal Chondroma-Like Masses in Mice

(2012) Leslie Cantley et al.   AMERICAN JOURNAL OF PATHOLOGY

A systematic review of the global prevalence of low back pain

(2012) Damian Hoy et al.   ARTHRITIS AND RHEUMATISM

Limb anterior–posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

(2012) Megan Bowers et al.   DEVELOPMENTAL BIOLOGY

The postnatal role of Sox9 in cartilage

(2012) Stephen P Henry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice

(2012) Philip E. Lapinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs

(2012) Kyung-Suk Choi et al.   MECHANISMS OF DEVELOPMENT

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium

(2011) Sheila M. Bell et al.   DEVELOPMENTAL BIOLOGY

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc

(2010) Philip Sohn et al.   BMC DEVELOPMENTAL BIOLOGY

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract

(2010) J. Mao et al.   DEVELOPMENT

Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

(2010) Christoph Weiler et al.   EUROPEAN SPINE JOURNAL

Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life

(2010) T. Hirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm

(2008) Lena Uetzmann et al.   GENESIS

A CK19CreERTknockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs

(2008) Anna L. Means et al.   GENESIS

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY