Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

(2013) Elizabeth A. Booth-Gauthier et al.   Integrative Biology

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

(2013) Wei-Chien Hung et al.   JOURNAL OF CELL BIOLOGY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

At the leading edge of three-dimensional cell migration

(2013) R. J. Petrie et al.   JOURNAL OF CELL SCIENCE

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Broken nuclei – lamins, nuclear mechanics, and disease

(2013) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

Physical confinement alters tumor cell adhesion and migration phenotypes

(2012) Eric M. Balzer et al.   FASEB JOURNAL

Nuclear deformation during breast cancer cell transmigration

(2012) Yi Fu et al.   LAB ON A CHIP

New dimensions in cell migration

(2012) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution

(2012) ZiQiu Tong et al.   PLoS One

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

(2012) Shyam B. Khatau et al.   Scientific Reports

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect

(2011) V. L. R. M. Verstraeten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer

(2011) Callinice D. Capo-chichi et al.   Chinese Journal of Cancer

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

(2010) E. S. Folker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Dysfunctional Connections Between the Nucleus and the Actin and Microtubule Networks in Laminopathic Models

(2008) Christopher M. Hale et al.   BIOPHYSICAL JOURNAL

The LINC-less granulocyte nucleus

(2008) Ada L. Olins et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry

(2008) Michael J. Rosenbluth et al.   LAB ON A CHIP