Article
Pharmacology & Pharmacy
Isra Khatib, Wei-Ren Ke, David Cipolla, Hak-Kim Chan
Summary: The novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) show promising results in terms of stability, with sucrose lyoprotectant demonstrating better performance than lactose under certain conditions. The storage stability of CNL powders varied with different protectants, highlighting the importance of proper storage conditions for maintaining the integrity and performance of these formulations over time.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Isra Khatib, Michael Y. T. Chow, Juanfang Ruan, David Cipolla, Hak-Kim Chan
Summary: The study optimized CNL powder production by evaluating the response surface via design of experiments (DoE), finding that sucrose and lactose were superior protectants compared to trehalose. The research demonstrates that the model developed was effective, and the optimum processing conditions for high drug encapsulation involved 57% sucrose, an 80°C inlet temperature, and an atomization rate of 742 L/hr.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
J. Alarcon-Moyano, D. Acuna, S. Matiacevich, L. Caballero, F. Melo, F. Quero, P. Diaz-Calderon
Summary: This study evaluated the physical-chemical properties and structure of cellulose nanocrystals (CNC) dried by two different methods: Spray-Drying (SD) or Freeze-Drying (FD). The results showed that the drying method influenced the size, aspect ratio, and sorption of CNC. However, it did not affect zeta potential, crystallinity, or degradation temperature. The study suggests that the drying method plays a role in modifying the physico-chemical properties of CNC.
FOOD HYDROCOLLOIDS
(2023)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Materials Science, Multidisciplinary
Amogh Kumar Baranwal, G. Keerthiga, L. Mohan, Sayan Deb Dutta, Pallavi Gupta, Ki-Taek Lim, Tuhin Subhra Santra
Summary: Titanium-dioxide nanotubes loaded with ciprofloxacin were fabricated using anodic oxidation. Coating the drug-loaded nanotubes with different thicknesses of PLGA allowed for controlled drug release, leading to better osseointegration and treatment of bone infections.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Andrea Fiorati, Francesca Baldassarre, Laura Riva, Stefano Tacconi, Concetta Nobile, Viviana Vergaro, Roberto Grisorio, Lucio Melone, Andrea Mele, Luciana Dini, Carlo Punta, Giuseppe Ciccarella
Summary: In this study, a spray drying process was used to produce nanostructured microsponges from TEMPO oxidized cellulose nanofibers (TOCNF). Different formulations were prepared by adjusting the oxidation degree of the nanofibers and the ratios of crosslinkers. The microsponges obtained from TOCNF with the highest carboxylic group content showed good colloidal stability and desired particle size. The microsponges were chemically characterized and exhibited pH-responsive swelling and drug release behavior. Moreover, the microsponges derived from formulations without citric acid were found to be biocompatible based on in vitro tests on gastric cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
San-San Ang, Yin Yin Thoo, Lee Fong Siow
Summary: This study investigated the potential of spray-dried chitosan-coated liposomes as delivery carriers for apigenin. These liposomes showed improved aqueous solubility, higher antioxidant capacity, and stability against simulated gastrointestinal digestion. The chitosan coating allowed for a slower release of apigenin.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Applied
Joaquin Gomez-Estaca, Alba Perez-Garcia, Ailen Aleman, M. Carmen Gomez-Guillen, Pilar Montero
Summary: The study evaluated the role of alginate in the drying and rehydration process of liposomal suspensions, showing that alginate can protect liposomes and provide protection at different pH levels.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Physical
Antonio Laezza, Antonietta Pepe, Auberi Henry, Laurent Duca, Brigida Bochicchio
Summary: This work describes a successful study on the delivery of salicylic acid from electrospun scaffolds. Hybrid scaffolds made of chitosan, cellulose nanocrystals, and poly-D,L-lactide polymers were produced, and the presence of these materials in the scaffolds was confirmed using various spectroscopic techniques. In vitro studies revealed the contribution of embedded polysaccharides to drug release and showed different degradation patterns. Additionally, the scaffolds were found to be non-toxic to fibroblast cell cultures.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wenhao Guan, Yanchao Liu, Shuaijie Ding, Yancai Wang
Summary: This study evaluated the feasibility and potential application of ciprofloxacin nanocrystals dry powder inhalations co-delivered with N-acetylcysteine in enhancing pulmonary drug delivery. The results demonstrated that the spray-dried dry powder inhaler exhibited desirable aerosol performance and flowability, making it a promising approach for efficient pulmonary drug delivery without causing severe lung injury.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Stefano Salmaso, Francesca Mastrotto, Marco Roverso, Valentina Gandin, Sara De Martin, Daniela Gabbia, Michele De Franco, Christian Vaccarin, Marco Verona, Adriana Chilin, Paolo Caliceti, Sara Bogialli, Giovanni Marzaro
Summary: Tyrosine kinase inhibitors (TKIs) are a promising class of therapeutics for cancer treatment, but their efficacy and toxicity can be influenced by CYP-mediated metabolism and drug-drug interactions. Developing a liposome formulation of a TKI prodrug (Pro962) specifically designed for tumor pH-controlled release can improve the metabolic stability, intracellular delivery, and release of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Luis Pereira, Frederico Castelo Ferreira, Filipa Pires, Carla A. M. Portugal
Summary: This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of DPPC:FA liposomes into magnetic-responsive gelatin membranes. The FA release mechanisms and kinetics from these liposomal gelatin systems were studied and compared to conventional drug delivery systems to assess their potential in longer-term therapeutics.
Article
Pharmacology & Pharmacy
Carlos Rodriguez-Nogales, Joke Meeus, Gaby Thonus, Sam Corveleyn, Eric Allemann, Olivier Jordan
Summary: Nano- and micro-technologies offer a solution for drugs with low solubility, improving their chances of success in pre-clinical and clinical stages. This study presents a unique design approach using drug nanocrystals loaded in extended release polymeric microparticles for local treatment of osteoarthritis. The results demonstrate the successful development of a formulation with high drug encapsulation rates, allowing for continuous and controlled drug release over four months.
Article
Biochemistry & Molecular Biology
Zahra Moazzami Goudarzi, Mahnaz Soleimani, Laleh Ghasemi-Mobarakeh, Pawel Sajkiewicz, Fariborz Sharifianjazi, Amirhossein Esmaeilkhanian, Samad Khaksar
Summary: A drug delivery system based on textile substrates and nanofibers was developed in this study for controlled drug release. The obtained samples showed potential for future wound dressing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Dariush Nikjoo, Ires van der Zwaan, Mikael Brulls, Ulrika Tehler, Goran Frenning
Summary: Hydrogels, particularly those made from hyaluronic acid (HA), show promise as a material for controlled pulmonary drug delivery. In this study, spray-dried microparticles were successfully prepared from crosslinked HA, with superior performance demonstrated by those crosslinked with glutaraldehyde (GA) in terms of aerosolization and swelling.
Review
Pharmacology & Pharmacy
Xingchen Bian, Xingyi Qu, Jing Zhang, Sue C. Nang, Phillip J. Bergen, Qi Tony Zhou, Hak-Kim Chan, Meiqing Feng, Jian Li
Summary: Antimicrobial resistance poses a major global health challenge, and peptide antibiotics serve as important therapeutic options for multidrug-resistant pathogen infections. Optimizing the exposure of peptide antibiotics at the infection site is crucial for improving treatment efficacy and reducing the emergence of resistance.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Rachel Yoon Kyung Chang, Yuko Okamoto, Sandra Morales, Elizabeth Kutter, Hak -Kim Chan
Summary: This study formulated liquid phage for topical delivery using a metered-dose spray and evaluated its properties and efficacy. The results showed that the optimized phage-polymer spray formulations were easily sprayable, with minimal dripping and fast drying time. The phages released rapidly from the formulation and effectively inhibited the growth of Pseudomonas aeruginosa. Both phages remained stable during storage for eight weeks. This study suggests that the spray formulations containing non-ionic polymers in ethanol/water could be a promising therapeutic system for delivering phages.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Infectious Diseases
Sue C. Nang, Yu-Wei Lin, Aleksandra Petrovic Fabijan, Rachel Y. K. Chang, Gauri G. Rao, Jonathan Iredell, Hak-Kim Chan, Jian Li
Summary: This review examines the current literature on phage pharmacology and highlights major pharmacological challenges for phage therapy. The lack of PK/PD information represents a major challenge for phage therapy, as therapeutic phages are biological entities with complex PK/PD.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Yuncheng Wang, Dipesh Khanal, Adit B. Alreja, Hang Yang, Rachel Y. K. Chang, Waiting Tai, Mengyu Li, Daniel C. Nelson, Warwick J. Britton, Hak-Kim Chan
Summary: This study investigated the feasibility of producing inhalable powders of endolysins Cpl-1 and ClyJ-3 using spray drying method with excipients. The results showed that ClyJ-3 lost its bioactivity before the drying process, while Cpl-1 maintained its bioactivity in the spray-dried powders. Cpl-1 formulations with leucine and either lactose or trehalose exhibited promising physico-chemical properties and aerosol performances. These findings suggest that endolysin Cpl-1 can be formulated as spray dry powders for potential treatment of pulmonary infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Dipesh Khanal, Jinhee Kim, Jing Zhang, Wei-Ren Ke, Mark M. Banaszak Holl, Hak Kim Chan
Summary: The aim of this research was to use optical photothermal infrared spectroscopy (OPTIR) to analyse the chemical composition of pharmaceutical dry powder inhalation (DPI) aerosol particles. The study confirmed the presence of specific chemical peaks related to the drugs and excipients in the size-segregated particles of DPI formulations. It also found that the drug to excipient distribution ratio varied in different formulations, indicating heterogeneity. The results showed that OPTIR can serve as a valuable analytical platform for screening the physicochemical properties of DPI aerosols in solid state.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Athiya Azeem, Gajendra Singh, Lunjian Li, Hak-Kim Chan, Runyu Yang, Shaokoon Cheng, Agisilaos Kourmatzis
Summary: This study quantified the probability of agglomerate-to-wall collision using a unique image processing technique. The purpose was to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates within a powder dispersion device.
PHARMACEUTICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok
Summary: The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. This review examines the preclinical and clinical evidence on the therapeutic use of CBD in treating various brain disorders, as well as different drug delivery approaches for CBD.
PHARMACEUTICAL RESEARCH
(2023)
Article
Oncology
Hiu Ting Chan, Satoshi Nagayama, Masumi Otaki, Yoon Ming Chin, Yosuke Fukunaga, Masashi Ueno, Yusuke Nakamura, Siew-Kee Low
Summary: This study compared the clinical utility and sensitivity of two different approaches to ctDNA analyses in colorectal cancer patients. It found that tumor-informed ctDNA analysis was more accurate in monitoring genetic mutations compared to tumor-agnostic analysis. Serial monitoring of ctDNA allowed for the early detection of disease recurrence, with a median of 5 months earlier than radiological imaging.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jieying Liang, Juanfang Ruan, Bosiljka Njegic, Aditya Rawal, Jason Scott, Jiangtao Xu, Cyrille Boyer, Kang Liang
Summary: Selecting an appropriate support material for enzyme immobilization is crucial in the development of functional biosystems. Covalent-organic frameworks (COFs) with metal-free and highly stable properties are found to be ideal supports. COF-LZU1, among three COFs developed in this study, is found to retain the highest activity when horseradish peroxidase (HRP) is incorporated. The structural analysis reveals that COF-LZU1 has the weakest interaction with the hydrated enzyme, easiest accessibility to the substrate, and optimal conformation of enzyme, which promote the bioactivity of HRP-COF-LZU1. COF-LZU1 also serves as a versatile nanoplatform for encapsulating multiple enzymes, providing superior protection under harsh conditions and during recycling. The understanding of interfacial interactions, substrate diffusion, and enzyme conformation alteration within COF matrices opens up possibilities for designing ideal biocatalysts and broad applications of these nanosystems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Dazhao Gou, Hak-Kim Chan, Agisilaos Kourmatzis, Runyu Yang
Summary: This study conducted a numerical investigation using coupled computational fluid dynamics (CFD) and discrete element method (DEM) to evaluate the impact of design changes in a commercial dry powder inhaler (DPI) device on the aerosolization of an API-only formulation. Six different designs were proposed by modifying the mouthpiece and chamber of the original geometry. The performances of these designs were evaluated in terms of powder deposition and fine powder fraction (FPF) in the device. The study found that the resistance and FPF emitted varied with different designs, highlighting the importance of the mouthpiece and chamber design on powder dispersion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Isra Khatib, Paul M. Young
Summary: Technegas, developed in Australia in the late 1980s, is a radioaerosol used for diagnosing pulmonary embolism (PE). It is produced by heating technetium-99m to generate technetium-carbon nanoparticles with gas-like behavior. Technegas has been widely used for diagnosis and shows potential in areas beyond PE. The review provides a historical evaluation of different methodologies' findings, discussing the technology's consensus and recent clinical innovations.
Article
Computer Science, Interdisciplinary Applications
Zhiwei Shen, Jingliang Dong, Liam Milton-McGurk, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis, Shaokoon Cheng
Summary: Understanding the effects of anatomical structures on nasal flow and particle deposition is important for drug delivery optimization and assessing the impact of pollutants and toxins inhalation. This study found that simplifying the geometry of the nasal cavity had minimal effect on airflow but influenced the location and quantity of particle deposition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Maziar Kakhi, Chandana Jayasundara, Ross Walenga, Srinivas Ravindra Babu Behara, Hak-Kim Chan, Runyu Yang
Summary: This study develops a numerical model to investigate the effect of aperture size on powder dispersion in dry powder inhalers. The results show that larger apertures can reduce the emptying time of the capsule and increase the particle evacuation velocity. However, the impact energy of collisions is not significantly affected by aperture size. It is also found that inside the capsule, particle-particle collisions are more frequent, while outside the capsule, particle-wall collisions are more frequent.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yue Cao, Dipesh Khanal, Jinhee Kim, Rachel Yoon Kyung Chang, Alex Seungyeon Byun, Sandra Morales, Mark M. Banaszak Holl, Hak-Kim Chan
Summary: This study investigates the effect of common organic solvents on the stability of bacteriophages. The results show that the bacteriophages are more stable in alcohols and DMSO, and myoviruses tend to be more stable than podoviruses. The choice of solvents for phage formulation depends on the specific phage and solvent types.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Cell Biology
Rohan Flint, Daniel R. Laucirica, Hak-Kim Chan, Barbara J. Chang, Stephen M. Stick, Anthony Kicic
Summary: Pulmonary bacterial infections pose a significant health risk to individuals with chronic respiratory diseases, and the emergence of antimicrobial resistance has necessitated the development of alternative therapies. Phage therapy, which targets antimicrobial-resistant pathogens, shows promise as an adjunct or alternative to antibiotics. Delivery of phages to the lungs is crucial for respiratory infections, and nebulization has been identified as a potential method. However, the factors that affect phage stability during nebulized delivery have not been fully characterized.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)