Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network

New Molecular Mechanism Underlying Myc‐Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium

(2018) Feifei Guan et al.   Journal of the American Heart Association

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner

(2017) Qingran Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

(2017) Noha M. Shawky et al.   PHARMACOLOGICAL RESEARCH

Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling

(2017) Zheng Li et al.   Oncology Letters

ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway

(2016) Alaide Domínguez-Calderón et al.   MOLECULAR BIOLOGY OF THE CELL

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation

(2015) Eva Barkauskaite et al.   MOLECULAR CELL

The critical role of Akt in cardiovascular function

(2015) Prasanna Abeyrathna et al.   VASCULAR PHARMACOLOGY

Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway Dynamics

(2015) Tri Hieu Nim et al.   PLoS Computational Biology

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Current Treatment of In-Stent Restenosis

(2014) Fernando Alfonso et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria

(2014) K Liu et al.   Cell Death & Disease

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Executive Summary: Heart Disease and Stroke Statistics—2013 Update

(2013) Alan S. Go et al.   CIRCULATION

Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition

(2013) Silvia Cantoni et al.   FEBS Journal

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Environmental exposures, epigenetics and cardiovascular disease

(2012) Andrea Baccarelli et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cardiovascular epigenetics: From DNA methylation to microRNAs

(2012) Silvia Udali et al.   MOLECULAR ASPECTS OF MEDICINE

Natural Inhibitors of Poly(ADP-ribose) Polymerase-1

(2012) Marek Banasik et al.   MOLECULAR NEUROBIOLOGY

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diet induced epigenetic changes and their implications for health

(2011) J. A. McKay et al.   Acta Physiologica

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epigenetics in cardiovascular disease

(2011) Apurva V Shirodkar et al.   CURRENT OPINION IN CARDIOLOGY

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells

(2010) Omana P. Mathew et al.   BIOMEDICINE & PHARMACOTHERAPY

Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway

(2010) Zhigang Bai et al.   CELL BIOLOGY INTERNATIONAL

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

mTOR phosphorylated at S2448 binds to raptor and rictor

(2009) M. Rosner et al.   AMINO ACIDS

RNA regulation of epigenetic processes

(2009) John S. Mattick et al.   BIOESSAYS

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease

(2009) D. Pons et al.   EUROPEAN HEART JOURNAL

Effect of butyrate on the heregulin/ErbB-mediated proliferation of human colorectal cancer cells

(2009) Lim   Molecular Medicine Reports

Mammalian Target of Rapamycin: Discovery of Rapamycin Reveals a Signaling Pathway Important for Normal and Cancer Cell Growth

(2009) James J. Gibbons et al.   SEMINARS IN ONCOLOGY

GSK-3/β-catenin signaling axis in airway smooth muscle: role in mitogenic signaling

(2008) Raquel O. Nunes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phosphoinositide 3-kinase signalling in the vascular system

(2008) F. Morello et al.   CARDIOVASCULAR RESEARCH

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetics at the Epicenter of Modern Medicine

(2008) Andrew P. Feinberg   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Akt Regulates the Survival of Vascular Smooth Muscle Cells via Inhibition of FoxO3a and GSK3

(2008) David Allard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY