Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial–Mesenchymal Transition in Cancer

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

(2019) Martin Köhler et al.   ONCOGENE

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

(2019) Vishal Das et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

(2019) Hyunkoo Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial Mesenchymal Transition in Tumor Metastasis

(2018) Vivek Mittal   Annual Review of Pathology-Mechanisms of Disease

Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways

(2018) Feng Dong et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Effect of ulixertinib, a novel ERK1/2 inhibitor, on the QT/QTc interval in patients with advanced solid tumor malignancies

(2018) Boaz Mendzelevski et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2

(2018) Yu He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy

(2018) Bijay S. Jaiswal et al.   CLINICAL CANCER RESEARCH

Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis

(2018) Jaroslav Kalous et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of partial EMT in cancer progression

(2018) Masao Saitoh   JOURNAL OF BIOCHEMISTRY

phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer

(2018) Cun Wang et al.   JOURNAL OF HEPATOLOGY

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

(2018) Andrew M. Kidger et al.   PHARMACOLOGY & THERAPEUTICS

New Insights into Modes of GPCR Activation

(2018) Wenjing Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition

(2018) V. Mali Aniket et al.   Cancer Biology & Medicine

The role of mitogen-activated protein kinase–extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation

(2018) Samira Kahnamouyi et al.   Therapeutic Advances in Endocrinology and Metabolism

Activation loop phosphorylation of ERK3 is important for its kinase activity and ability to promote lung cancer cell invasiveness

(2018) Lobna Elkhadragy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its functions: A recent update

(2018) Andy T. Y. Lau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway

(2018) Haibin Wu et al.   ONCOLOGY REPORTS

Leptin induces epithelial-to-mesenchymal transition via activation of the ERK signaling pathway in lung cancer cells

(2018) Min Xu et al.   Oncology Letters

ZNF259 promotes breast cancer cells invasion and migration via ERK/GSK3β/snail signaling

(2018) Bin Liu et al.   Cancer Management and Research

Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer

(2018) Monserrat Olea-Flores et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling

(2018) Satoshi Inoue et al.   Endocrine Connections

TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway

(2017) Lanfang Wu et al.   FEBS Journal

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling

(2017) Simon J. Cook et al.   FEBS Journal

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

(2017) Marco Sciacovelli et al.   FEBS Journal

ERK pathway activation contributes to the tumor-promoting effects of hepatic stellate cells in hepatocellular carcinoma

(2017) Yu-Xiao Xie et al.   IMMUNOLOGY LETTERS

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point

(2017) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)

(2017) Ursula A. Germann et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin reverses tobacco smoke‑induced epithelial‑mesenchymal transition by suppressing the MAPK pathway in the lungs of mice

(2017) Zhaofeng Liang et al.   Molecular Medicine Reports

A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer

(2017) N V Sankpal et al.   ONCOGENE

Phosphorylation: Implications in Cancer

(2017) Vishakha Singh et al.   PROTEIN JOURNAL

ERK signalling modulates epigenome to drive epithelial to mesenchymal transition

(2017) Mohit Navandar et al.   Oncotarget

AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling

(2017) Jia Li et al.   Oncotarget

Molecular signaling in multiple myeloma: association of RAS/RAF mutations and MEK/ERK pathway activation

(2017) J Xu et al.   Oncogenesis

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview

(2017) Do Kim et al.   Journal of Clinical Medicine

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2

(2017) Maria Perander et al.   Scientific Reports

Targeted Covalent Inhibitors for Drug Design

(2016) Thomas A. Baillie   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNA-200b-3p suppresses epithelial-mesenchymal transition and inhibits tumor growth of glioma through down-regulation of ERK5

(2016) Jianguo Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells

(2016) Soon-Ki Hong et al.   CANCER LETTERS

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

Osimertinib for the Treatment of Metastatic EGFR T790M Mutation–Positive Non–Small Cell Lung Cancer

(2016) Sean Khozin et al.   CLINICAL CANCER RESEARCH

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers

(2016) Jongwon Lim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain

(2016) Li-na Yu et al.   Journal of Zhejiang University-SCIENCE B

Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

(2016) Amir Mehdizadeh et al.   MOLECULAR BIOLOGY REPORTS

Adaptive Randomization of Neratinib in Early Breast Cancer

(2016) John W. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epithelial–mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

(2016) D Fang et al.   ONCOGENE

The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

(2016) L-Y Chiu et al.   ONCOGENE

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

(2016) Jianguo Wu et al.   eLife

Post-translational modifications of EMT transcriptional factors in cancer metastasis

(2016) Rui Chang et al.   Open Life Sciences

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf

(2015) Ramin Samadani et al.   BIOCHEMICAL JOURNAL

Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase

(2015) Jeffrey T. Bagdanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase

(2015) Jeffrey T. Bagdanoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes

(2015) Ana Herrero et al.   CANCER CELL

Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling

(2015) Yinghua Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia

(2015) R. A. de Claro et al.   CLINICAL CANCER RESEARCH

p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

(2015) Maria Radu et al.   MOLECULAR AND CELLULAR BIOLOGY

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs

(2015) S. Javaid et al.   MOLECULAR CANCER RESEARCH

miR-143 suppresses epithelial-mesenchymal transition and inhibits tumor growth of breast cancer through down-regulation of ERK5

(2015) Limin Zhai et al.   MOLECULAR CARCINOGENESIS

MCRIP1, an ERK Substrate, Mediates ERK-Induced Gene Silencing during Epithelial-Mesenchymal Transition by Regulating the Co-Repressor CtBP

(2015) Kenji Ichikawa et al.   MOLECULAR CELL

Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway

(2015) C Peng et al.   ONCOGENE

Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation

(2015) Yong-Qu Zhang et al.   PLoS One

A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration

(2015) Rania Al-Mahdi et al.   Cell Adhesion & Migration

Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun

(2015) Dong-Hao Jin et al.   Oncotarget

Comparative analysis of KRAS codon 12, 13, 18, 61 and 117 mutations using human MCF10A isogenic cell lines

(2015) Britta Stolze et al.   Scientific Reports

ExtendedRASmutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials

(2014) M. J. Sorich et al.   ANNALS OF ONCOLOGY

HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression

(2014) Yang Li et al.   CANCER LETTERS

ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors

(2014) E. M. Goetz et al.   CANCER RESEARCH

MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking

(2014) M. E. Arcila et al.   CLINICAL CANCER RESEARCH

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis

(2014) R. Strippoli et al.   EMBO Molecular Medicine

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

(2014) Qiang Ding et al.   Molecular Cancer

Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway

(2014) Chun-Han Hou et al.   Molecular Cancer

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

(2014) Apirat Chaikuad et al.   Nature Chemical Biology

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

(2014) Neroshan Thevakumaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA-7 Inhibits Tumor Metastasis and Reverses Epithelial-Mesenchymal Transition through AKT/ERK1/2 Inactivation by Targeting EGFR in Epithelial Ovarian Cancer

(2014) Xingchen Zhou et al.   PLoS One

Snail Promotes Epithelial Mesenchymal Transition in Breast Cancer Cells in Part via Activation of Nuclear ERK2

(2014) Bethany N. Smith et al.   PLoS One

Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition

(2013) Shilpa Vyas-Read et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hierarchical scaffolding of an ERK1/2 activation pathway

(2013) Susanne Vetterkind et al.   Cell Communication and Signaling

Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

(2013) Ying Meng et al.   CHINESE CHEMICAL LETTERS

Prognostic impact of pERK in advanced hepatocellular carcinoma patients treated with sorafenib

(2013) D. Chen et al.   EJSO

SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer

(2013) JIA GU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

(2013) I. A. Elsum et al.   JOURNAL OF CELL SCIENCE

High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

(2013) Rui Liao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

(2013) Alyson K. Freeman et al.   MOLECULAR CELL

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

(2013) Peter D. Mace et al.   Nature Communications

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells

(2012) M. B. Weiss et al.   CANCER RESEARCH

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer

(2012) T. Shimizu et al.   CLINICAL CANCER RESEARCH

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

(2012) Michael Röring et al.   EMBO JOURNAL

Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition

(2012) TOSHIYUKI TANAHASHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

(2012) Weiwen Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of acquired resistance to ERK1/2 pathway inhibitors

(2012) A S Little et al.   ONCOGENE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Oncogenic and Wild-type Ras Play Divergent Roles in the Regulation of Mitogen-Activated Protein Kinase Signaling

(2012) Amy Young et al.   Cancer Discovery

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

(2011) Peter C. Hollenhorst et al.   Annual Review of Biochemistry

Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness

(2011) J. Hong et al.   CANCER RESEARCH

Microwave-assisted synthesis, crystal structure of pyrazolo[1,5-a]pyrazin-4(5H)-ones and their selective effects on lung cancer cells

(2011) Ning Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells

(2011) Gabriel T. M. Lok et al.   PLoS One

Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

(2011) A. S. Little et al.   Science Signaling

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

(2011) S. M. Carlson et al.   Science Signaling

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

(2010) Alexander Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Extracellular Signal-Regulated Kinase 8-Mediated c-Jun Phosphorylation Increases Tumorigenesis of Human Colon Cancer

(2010) Y. M. Xu et al.   CANCER RESEARCH

Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics

(2010) Jeremy L. Yap et al.   ChemMedChem

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

(2010) Anja E. Eisenhardt et al.   INTERNATIONAL JOURNAL OF CANCER

Quantitative Analysis of ERK2 Interactions with Substrate Proteins

(2010) Kimberly A. Burkhard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

Analysis of the genome to personalize therapy for melanoma

(2010) M A Davies et al.   ONCOGENE

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

(2010) K Nagasaka et al.   ONCOGENE

Partner exchange: protein–protein interactions in the Raf pathway

(2010) Reiner Wimmer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

(2009) Anna Kucharska et al.   CELLULAR SIGNALLING

Selectivity of Docking Sites in MAPK Kinases

(2009) A. Jane Bardwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation

(2009) Diane S. Lidke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control

(2009) Alex M. Aronov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

(2009) D. A. Ritt et al.   MOLECULAR AND CELLULAR BIOLOGY

The subcellular localization of MEK and ERK—A novel nuclear translocation signal (NTS) paves a way to the nucleus

(2009) Eldar Zehorai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality

(2009) S. Klinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

The RSK factors of activating the Ras/MAPK signaling cascade

(2008) Audrey Carriere   Frontiers in Bioscience-Landmark

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

(2008) Douglas L. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

(2008) Marjorie Maillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5

(2008) Paul Déléris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes

(2008) Berta Casar et al.   MOLECULAR CELL

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE