Article
Chemistry, Physical
Faezeh Sharifi, Mansour Jahangiri, Imran Nazir, Mulazim Hussain Asim, Pedram Ebrahimnejad, Andrea Hupfauf, Ronald Gust, Andreas Bernkop-Schnurch
Summary: Phosphorylated tyramine loaded nanoemulsion showed a mean droplet size of 43.1.7 nm and zeta potential of -8.40 mV, with a significant shift in zeta potential from -8.40 mV to +1.2 mV after cleaving phosphate moieties. The cellular uptake of zeta potential changing oily droplets was improved by 2.4-fold. Phosphorylated zwitterions could be a promising alternative as auxiliary agents for altering zeta potential in nanoemulsions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Polymer Science
Zhiming Chen, Weiqiu Wen, Jianwei Guo
Summary: The study synthesized a hypoxia-sensitive amphiphilic conjugate by conjugating natural chitosan with nitrobenzyl chloroformate, which formed nano micelles with high stability and demonstrated hypoxia-responsive function. The encapsulated drug, doxorubicin, showed rapid release in hypoxic environment with high anti-cancer efficacy, indicating promising potential for tumor treatment as a drug delivery system.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Biochemistry & Molecular Biology
Ali Pourjavadi, Fatemeh Bolori Kashani, Mohadeseh Doroudian, Shiva Sadat Amin
Summary: The primary objective of this paper is to study the synthesis of stimulus-sensitive micelles based on polysaccharides. Functionalization with polylactide (PLA) and poly[2(Dimethyl amino)ethyl methacrylate] (PDMAEMA) or poly(methacrylic acid) (PMA) was used to create micelles with a simple structure. Characterization of the functionalized polysaccharides and determination of critical micelle concentration were conducted using FTIR, 1HNMR, and fluorescence spectroscopy. Micelle diameter was observed in SEM and TEM pictures, ranging from 50 to 200 nm. Drug release tests, cytotoxicity assessment, and cellular uptake studies were carried out to evaluate the potential of these micelles for drug delivery. The results indicate that the behavior of the micelles is similar, regardless of the charge densities or stimulus-sensitive polymers used in the polysaccharides. This approach demonstrates the versatility of diverse polysaccharides functionalized with PLA and polymethacrylates for micelle production.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Paola Mura, Francesca Maestrelli, Marzia Cirri, Natascia Mennini
Summary: Chitosan (CS) is a polysaccharide that is obtained from the deacetylation of chitin, making it the second most abundant biopolymer in nature after cellulose. It has attracted great interest in the pharmaceutical field due to its various beneficial features, including biocompatibility, biodegradability, non-toxicity, and simplicity of chemical modifications. CS is capable of forming films, hydrogels, and micro- and nanoparticles, and its cationic character allows for strong interactions with different molecules and exhibits antimicrobial, anti-inflammatory, and hemostatic activities. However, its solubility is pH-dependent and it is susceptible to ions, which may pose challenges. Currently, CS and its derivatives are widely investigated for pharmaceutical applications, particularly in mucosal drug delivery.
Article
Chemistry, Applied
Menghan Wu, Yanning Li, Jinge Li, Shuang Xu, Zhengbiao Gu, Li Cheng, Yan Hong
Summary: In this study, a method for synthesizing starch phosphate using the transferase properties of alkaline phosphatase was successfully explored. The crystallinity and enthalpy of the phosphorylated samples were reduced by up to 26.8% and 23.3%, respectively, and the grafting of phosphate radicals was further confirmed by X-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Bao Le-Vinh, Zeynep Burcu Akkus-Dagdeviren, Nguyet-Minh Nguyen Le, Imran Nazir, Andreas Bernkop-Schnuerch
Summary: Alkaline phosphatase has been widely used in drug delivery and diagnostics. By cleaving phosphate substructures from drugs and nanocarriers, this enzyme allows drug delivery systems to change their properties in the body. It can also facilitate the accumulation of nanocarriers at target sites and trigger targeted drug release.
ADVANCED THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Bao Le-Vinh, Christian Steinbring, Richard Wibel, Julian David Friedl, Andreas Bernkop-Schnuerch
Summary: This study aimed to prepare a size-shifting nanocarrier for site-targeting mucosal drug delivery. Solid lipid nanoparticles loaded with a phosphate ester surfactant and octadecylamine were utilized, and alkaline phosphatase was used as an in situ partner for triggering the size conversion at epithelial cell surface. The developed SLN system shows potential for mucosal drug delivery to AP-expressing tissues.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Mengting Lv, Huanan Li, Hua Cao, Teng Wang, Chengdian He, Yi Liang, Xiang Mao, Zhenyu Wang
Summary: This study presents a novel alkaline-responsive drug carrier, CS-GL, fabricated using a microfluidic approach with ultrasound assistance. The carrier exhibits high drug encapsulation efficiency and stable structure, enabling rapid drug release under both acidic and alkaline conditions.
Article
Pharmacology & Pharmacy
Naoto Yoshino, Hanae Kawamura, Ikumi Sugiyama, Yutaka Sasaki, Takashi Odagiri, Yasuyuki Sadzuka, Yasushi Muraki
Summary: The study found that amphoteric surfactants can serve as potent mucosal adjuvants, with their adjuvanticity influenced by the number of carbon atoms in the hydrophobic tailgroups, while the diameter and zeta-potential of the complexes also play crucial roles in immune responses.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Almudena Naharros-Molinero, Maria Angela Caballo-Gonzalez, Francisco Javier de la Mata, Sandra Garcia-Gallego
Summary: This review provides an overview of the main parameters affecting the micellization process of Pluronics and presents common techniques for characterizing the structure and properties of the micelles. It also discusses approaches to improving the stability and drug loading of Pluronic micelles, with a focus on reverse Pluronics and reverse micelles which have been underexplored in the literature.
Article
Nanoscience & Nanotechnology
Kedong Liu, Yun Chen, Dutao Yang, Yanfei Cai, Zhaoqi Yang, Jian Jin
Summary: Developing a hybrid micelle platform for oral drug delivery, with the ability to overcome both mucus permeation and epithelium absorption barriers, was investigated in this study. The optimized hybrid micelle exhibited excellent mucus and villi penetration capabilities, as well as enhanced cellular uptake. The results also indicated the involvement of the retrograde pathway in the intracellular transport and transcytosis delivery of the hybrid micelles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yuting Yuan, Zhenhua Wang, Shengjia Su, Yingqi Mi, Qing Li, Fang Dong, Wenqiang Tan, Zhanyong Guo
Summary: Amphiphilic low molecular weight chitosan-lipoic acid (LC-LA) conjugates with different degrees of substitution (DS) of LA were synthesized by N, N'-carbonyldiimidazole (CDI) catalysis to self-assemble into redox-sensitive micelles. The blank micelles showed excellent biocompatibility and redox-sensitive behavior with low critical micelle concentration (CMC), nano-scale size, and positive zeta potential. Doxorubicin (Dox) loaded micelles exhibited redox-trigger behavior, strong antitumor activity, and increased cellular uptake efficiency against A549 cell.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Nazafarin Samiraninezhad, Khatereh Asadi, Hojat Rezazadeh, Ahmad Gholami
Summary: This review summarizes the current research on applying smart natural polymer-based hydrogels for drug delivery in oral mucosal lesions. Smart biological hydrogels show great promise as topical drug delivery systems, offering sustained drug release, increased therapeutic efficacy, and minimized systemic complications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Review
Biochemistry & Molecular Biology
Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Summary: Osteosarcoma is prevalent in children and adolescents with ineffective conventional treatments, necessitating the development of novel drugs and bone-repairing methods. Chitosan, a natural compound, exhibits anti-tumor activities and can be utilized in drug delivery and diagnostic techniques.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Zeynep Burcu Akkus-Dagdeviren, Andrea Fuerst, Julian David Friedl, Martina Tribus, Andreas Bernkop-Schnuerch
Summary: This study investigates the combined usage of Layer-by-Layer coating and alkaline phosphatase-responsive charge reversal strategies in colloidal drug delivery systems. The findings show that this combination improves cellular internalisation and decreases cytotoxic effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Victor Claus, Helen Spleis, Christoph Federer, Katrin Zoeller, Richard Wibel, Flavia Laffleur, Camille Dumont, Philippe Caisse, Andreas Bernkop-Schnuerch
Summary: In this study, the lipophilicity of insulin glargine was increased through hydrophobic ion pairing with sodium octadecyl sulfate, enabling its incorporation into self-emulsifying drug delivery systems (SEDDS). Two SEDDS formulations were developed and loaded with the insulin glargine-HIP complex. The results showed that the bioavailability of the complexed insulin glargine in the SEDDS formulations was significantly increased after oral administration in rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Arshad Mahmood, Laraib Khan, Muhammad Ijaz, Imran Nazir, Mahrukh Naseem, Muhammad Azam Tahir, Muhammad Naeem Aamir, Masood Ur Rehman, Mulazim Hussain Asim
Summary: This study aimed to increase the solubility, improve drug release, and intestinal permeability of Cefixime (CFX) by loading it into self-emulsifying drug delivery systems (SEDDS). The best formulation, F-2, exhibited high drug loading, short emulsification time, and small droplet size. In vitro release and permeation studies showed that CFX-loaded SEDDS had better permeability compared to the marketed product. Therefore, CFX-loaded SEDDS could improve the bioavailability and antibacterial activity, leading to enhanced therapeutic effectiveness.
Article
Multidisciplinary Sciences
Muhammad Asad, Akhtar Rasul, Ghulam Abbas, Muhammad Ajmal Shah, Imran Nazir
Summary: Biopharmaceutical classification systems (BCS) class III drugs, characterized by high solubility and low membrane permeability, have low bioavailability. This study aimed to improve the bioavailability of these drugs by incorporating them into self-emulsifying drug delivery systems (SEDDS), using hydrophobic ion pairs (HIPs) of tobramycin (TOB) as a model drug. The HIPs were formulated using anionic surfactants and their efficiency was evaluated. The suitable excipients for SEDDS development were then screened, and the loaded complexes were assessed for their release and dissociation characteristics. The study found that the lipophilic nature of BCS class III drugs can be enhanced by incorporating them into oily droplets, thus improving their permeation across biological membranes.
Article
Nanoscience & Nanotechnology
Bao Le-Vinh, Christian Steinbring, Nguyet-Minh Nguyen Le, Barbara Matuszczak, Andreas Bernkop-Schnurch
Summary: Chitosan and its derivatives with high cell adhesion properties were designed and tested for their suitability as scaffold materials in tissue engineering. The attachment of a thiol group to chitosan significantly improved cell adhesion, with higher modification levels leading to better results. The resulting chitosan-based cryogels showed promise for 3D cell culture and tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Sobia Noreen, Andreas Bernkop-Schnuerch
Summary: Thiolation of poly- and oligosaccharides introduces various favorable properties for tissue engineering and wound healing, including stable 3D networks, enhanced cell adhesion and signaling, and controlled release of active ingredients.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Gergely Kali, Bengi Ozkahraman, Flavia Laffleur, Patrick Knoll, Richard Wibel, Katrin Zoller, Andreas Bernkop-Schnurch
Summary: This study aimed to design and evaluate an anionic, thiolated cellulose derivative for its mucoadhesive and permeation-enhancing properties using enoxaparin as a model drug. The thiolated cellulose exhibited enhanced mucoadhesion on porcine intestinal mucosa and improved permeation in Caco-2 cell monolayer. In vivo studies in rats showed significantly higher oral bioavailability compared to the aqueous solution of the drug.
Article
Pharmacology & Pharmacy
Victor Claus, Matthias Sandmeier, Nathalie Hock, Helen Spleis, Sera Lindner, Monika Kalb, Andreas Bernkop-Schnuerch
Summary: In this study, the lipophilicity of model proteins was increased by combining various surfactants with insulin, bovine serum albumin, and horseradish peroxidase. The key factors responsible for complex formation were identified. The formed complexes were stable in simulated gastrointestinal fluids and could be incorporated into self-emulsifying drug delivery systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zeynep Burcu Akkus-Dagdeviren, Sema Arisoy, Julian David Friedl, Andrea Fuerst, Ahmad Saleh, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop enzyme-activated charge-reversal lipid nanoparticles (LNPs) as novel gene delivery systems. The researchers successfully anchored a transfection promoter on the surfaces of LNPs to achieve high encapsulation and efficient gene delivery. The experiment results showed that the enzyme-triggered charge reversal of LNPs resulted in significantly increased transfection efficiency in human alveolar epithelial cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Nathalie Hock, Dennis To, Eva Sanchez Armengol, Simona Summonte, Anna Seybold, Christoph Federer, Andreas Bernkop-Schnuerch
Summary: The aim of this study was to develop biodegradable polyphosphate nanoparticles as long-acting drug delivery systems by utilizing ubiquitarian alkaline phosphatase. The nanoparticles were prepared and characterized, showing good stability and release characteristics. The results also demonstrated their biocompatibility and lack of toxicity. These findings open up new opportunities in parenteral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Florina Veider, Eva Sanchez Armengol, Andreas Bernkop-Schnuerch
Summary: The past two decades have seen significant progress in the development of surface charge-reversible nanoparticles for drug delivery and diagnosis. These nanoparticles can change their surface charge from negative to positive at the target site, thereby improving drug delivery and diagnostic agent sensitivity. They have also shown potential in overcoming biofilms and delivering antibiotics directly to cell membranes of microorganisms. This review highlights the latest design and emerging applications of charge-reversible nanoparticles in drug delivery and diagnosis.
Article
Engineering, Biomedical
Arne Matteo Joergensen, Christian Steinbring, Daniel Stengel, Dennis To, Pascal Schmid, Andreas Bernkop-Schnuerch
Summary: This study developed self-emulsifying drug delivery systems containing dry reverse micelles (SEDDS-dRMsPMB) loaded with the model peptide drug polymyxin B (PMB) using anionic (AOT), cationic (DODAB), amphoteric (SL), or non-ionic (P85) surfactants. These systems showed high payload, efficient cellular uptake, and maintained antimicrobial activity, suggesting a potential game-changing strategy for oral peptide drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Dennis To, Gergely Kali, Soheil Haddadzadegan, Arne Matteo Joergensen, Katharina Nigl, Fabrizio Ricci, Andreas Bernkop-Schnuerch
Summary: Nanoemulsions with enhanced gastro-intestinal retention time can be achieved by incorporating thiolated surfactants into their surface. Two generations of thiolated surfactants were synthesized and characterized, and their incorporation into nanoemulsions improved the mucoadhesiveness. S-protected thiol derivatives showed the highest mucoadhesive properties among all tested surfactants.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Katrin Zoeller, Anna Karlegger, Martyna Truszkowska, Daniel Stengel, Andreas Bernkop-Schnuerch
Summary: This study investigates the cellular uptake of hydrophobic complexes via nanocarriers using hydrophobic ion pairs (HIPs) formed between two fluorescent components. The results show that HIPs increase the lipophilicity of the model drugs and incorporating HIPs into nanoemulsions (NE) further enhances cellular uptake. HIPs serve as a powerful tool to visualize the cellular distribution of hydrophobic complexes and study their cellular uptake.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)