Article
Biophysics
Nazanin Amiryaghoubi, Elaheh Dalir Abdolahinia, Ailar Nakhlband, Shaghayegh Aslzad, Marziyeh Fathi, Jaleh Barar, Yadollah Omidi
Summary: Chitosan-based pH-sensitive nanocomposites were developed for targeted delivery of doxorubicin to osteosarcoma cells. The nanocomposites exhibited enhanced drug release under acidic conditions and showed high cellular uptake and cytotoxicity in folate receptor-expressing cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Yanshan Sheng, Cheng Cao, Zhengyin Liang, Zheng-Zhi Yin, Jun Gao, Wenrong Cai, Yong Kong
Summary: A dual-drug delivery system based on oxidized alginate and carboxymethyl chitosan has been developed for efficient treatment of osteosarcoma. The system utilizes chemical reactions between oxidized alginate and carboxymethyl chitosan, as well as the photothermal effect of near-infrared light, to achieve dual-responsive delivery of methotrexate and naringin. The therapeutic efficacy of the system against osteosarcoma has been significantly improved through chemophotothermal synergistic therapy, as confirmed by cytotoxicity testing.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Iyyakkannu Sivanesan, Judy Gopal, Manikandan Muthu, Juhyun Shin, Selvaraj Mari, Jaewook Oh
Summary: This review discusses the preparation, drug delivery applications, and current status of green synthesis of chitosan. It highlights the lack of systematic research in the green synthesis of chitosan and calls for more innovative green processes to be explored. Additionally, there is a lack of reports on the application of green synthesized chitosan nanoforms and nanocomposites towards drug delivery applications, which is an area that deserves more research focus.
Review
Pharmacology & Pharmacy
Yulin Hou, Jie Wang, Jianping Wang
Summary: Chemotherapy drugs are crucial in treating osteosarcoma, but their toxic side effects, including cardiotoxicity, cannot be ignored. Biomaterials as drug carriers can precisely deliver drugs to tumor cells and reduce cardiotoxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Julie Frigaard, Janicke Liaaen Jensen, Hilde Kanli Galtung, Marianne Hiorth
Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Applied
S. Peers, A. Montembault, C. Ladaviere
Summary: This review focuses on the development of complex drug delivery systems composed of chitosan hydrogels embedding different types of colloids to achieve delayed drug release. The review also provides detailed information on the biomedical applications of these final systems.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Raquel de Castro, Gurshagan Kandhola, Jin-Woo Kim, Quincy C. Moore, Audie K. Thompson
Summary: Drug delivery systems (DDS) face challenges such as high systemic uptake and low bioavailability. This study developed a new DDS using chitosan (Cs) particles and composite films to encapsulate gentamicin (GtS). Lysozyme can degrade chitosan to release GtS, and poly(ethylene glycol) diacrylate (PEGDA) can increase drug encapsulation efficiency. Cross-linking can prevent premature drug release.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Haorui Zhang, Ping Luo, Xiaojun Huang
Summary: Osteosarcoma is the most common malignant bone tumor in adolescents, and its clinical treatment involves surgery, radiotherapy, and chemotherapy. However, the side effects of chemotherapy drugs cannot be ignored. Nanomedicine and drug delivery technologies have played a significant role in modern medicine, particularly in the treatment of tumors. Nanoparticles have shown promising results in reducing the toxic side effects of chemotherapy drugs and improving the survival rate of osteosarcoma patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Review
Pharmacology & Pharmacy
Ayah Mohammad Burhan, Butsabarat Klahan, Wayne Cummins, Vanessa Andres-Guerrero, Mark E. Byrne, Niall J. O'Reilly, Anuj Chauhan, Laurence Fitzhenry, Helen Hughes
Summary: This study presents an overview of posterior segment eye diseases, barriers to topical drug delivery, and the application of chitosan in ophthalmic drug delivery. It discusses how mucoadhesive formulations can help enhance drug delivery to the posterior eye segment.
Article
Biochemistry & Molecular Biology
Preeti Yadav, Awadh Bihari Yadav, Preksha Gaur, Vartika Mishra, Zul- Huma, Neelesh Sharma, Young-Ok Son
Summary: Mastitis is a devastating economic disease in dairy cattle, commonly occurring during the dry period or early lactation. Escherichia coli and Staphylococcus aureus are the main causative agents of mastitis in India. The use of ciprofloxacin-encapsulated nanocarriers shows potential in improving drug availability and providing an effective treatment for mastitis.
Review
Polymer Science
Iyyakkannu Sivanesan, Shadma Tasneem, Nazim Hasan, Juhyun Shin, Manikandan Muthu, Judy Gopal, Jae-Wook Oh
Summary: Chitosan has made significant progress in biomedical applications, particularly in the field of drug delivery. Modified chitosan derivatives have overcome limitations and advanced drug delivery. This article reviews the current chitosan derivatives used in biomedical applications and discusses their importance in oral drug delivery. It points out the limited use of chitosan resources in oral drug delivery and possible reasons for this.
Review
Biochemistry & Molecular Biology
Ghazaleh Salmanian, S. A. Hassanzadeh-Tabrizi, Narjes Koupaei
Summary: Magnetic chitosan nanocomposites with multifunctional tasks such as localized tumor heating under magnetic field and controlled drug release are highly demanded. Combining different types of magnetic cores and engineered chitosan shells can create unique characteristics with biocompatibility, the least toxic effects, controlled drug release, and the ability to carry various medicines for long-term circulation in the body. Recent advances in the synthesis and applications of magnetic chitosan nanocomposites for hyperthermia and drug delivery are summarized in this review.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Masomeh Maleki, Asal Golchin, Samira Javadi, Nafiseh Khelghati, Pejman Morovat, Zatollah Asemi, Forough Alemi, Mostafa Vaghari-Tabari, Bahman Yousefi, Maryam Majidinia
Summary: Exosomal miRNA plays an important role in the chemo-resistance, diagnosis, and prognosis of colorectal cancer (CRC). Engineered exosomes can deliver functional miRNAs to reverse chemoresistance and serve as promising biomarkers for CRC.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Marziyeh Salami, Raziyeh Salami, Mohammad-Hossein Aarabi, Alireza Mafi, Seyedeh Sara Ghorbanhosseini, Rana Shafabakhsh, Zatollah Asemi
Summary: Gliomas, especially glioblastoma, are highly resistant to existing treatments and have a low prognosis, necessitating the search for new treatment options. Nutraceuticals have shown promise in inhibiting tumor growth, angiogenesis, and inducing apoptosis in cancer cells, including glioma. These compounds can target cellular signaling pathways and other mechanisms to disrupt cancer cells. Recent studies have identified potential target molecules and signaling pathways affected by nutraceuticals in glioma cells, suggesting that clinical trials and new approaches are imminent.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousefi
Summary: Osteosarcoma is the most common primary bone malignancy among children and adolescents, and its high mortality rate is mainly due to lung metastasis. Traditional chemotherapy and surgical treatment have limited efficacy in reducing metastasis rate and improving prognosis. Therefore, it is necessary to explore new therapeutic strategies to enhance the survival rate of osteosarcoma patients. Curcumin, a compound derived from Curcuma longa, has been shown to have multiple anti-cancer effects. Studies have demonstrated that curcumin can inhibit cell proliferation and induce apoptosis in osteosarcoma cells. Additionally, research has identified several signaling pathways involved in the pathogenesis of osteosarcoma, and curcumin has been evaluated for its potential to regulate these pathways and improve treatment outcomes.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Pouya Mahdavi Sharif, Parisa Maleki Dana, Zatollah Asemi
Summary: Gastrointestinal (GI) cancers are prevalent worldwide with increasing incidence. Treatment options for these cancers are limited and new strategies are needed. Resveratrol, a natural product found in fruits and plants, has been studied for its effects on microRNAs in neoplastic disorders. This review aims to illustrate the molecular pathways related to resveratrol and evaluate its impacts on microRNAs in the prevention and treatment of GI cancers.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Bahman Yousefi, Zatollah Asemi
Summary: Melatonin, a secretion of the pineal gland, has been found to have significant effects on tumor tissues, including inhibiting tumor growth, promoting apoptosis, and suppressing angiogenesis. Current therapeutic strategies for bone cancer are limited, and there is a need to better understand the molecular pathways and cellular functions associated with this disease in order to develop new treatments. This review summarizes the functions of melatonin in osteosarcoma and Ewing's sarcoma, as well as its mechanisms of action as an antitumor agent and its synergistic effects with other chemotherapy drugs.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Mafi
Summary: Circular RNAs (circRNAs) play important roles in the pathogenesis of Alzheimer's disease (AD) by acting as miRNA sponges or gene transcription modulators, involved in the accumulation of Aβ peptides and tau protein, and have been reported as potential diagnostic and therapeutic biomarkers in AD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pharmacology & Pharmacy
Malihe Rezaee, Fatemeh Mohammadi, Atoosa Keshavarzmotamed, Sheida Yahyazadeh, Omid Vakili, Yaser Eshaghi Milasi, Vida Veisi, Rohollah Mousavi Dehmordi, Sepideh Asadi, Seyedeh Sara Ghorbanhosseini, Mehdi Rostami, Mina Alimohammadi, Abbas Azadi, Nushin Moussavi, Zatollah Asemi, Azadeh Aminianfar, Hamed Mirzaei, Alireza Mafi
Summary: Breast cancer is the most common cancer among women worldwide, and drug resistance is a major challenge in its treatment. Exosomal non-coding RNAs have the potential to regulate the molecular mechanisms and pathways related to breast cancer progression and drug resistance, and also serve as biomarkers for diagnosis and prognosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Atefe Rahmati, Alireza Mafi, Firooze Soleymani, Zahra Babaei Aghdam, Niloufar Masihipour, Behrooz Ghezelbash, Reza Asemi, Michael Aschner, Omid Vakili, Mina Homayoonfal, Zatollah Asemi, Mehran Sharifi, Abbas Azadi, Hamed Mirzaei, Esmat Aghadavod
Summary: Acute myeloid leukemia (AML) is a aggressive hematological malignancy with poor overall survival rates. Circular RNAs (circRNAs), a class of non-coding RNAs with a unique loop structure, have been found to be dysregulated in AML patients. These dysregulated circRNAs have been shown to regulate leukemia cell proliferation, stemness, and apoptosis in both positive and negative ways. Furthermore, circRNAs show potential as biomarkers and therapeutic targets in AML.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezaee
Summary: Polyphenols, which are abundant in regular diets, have various beneficial effects such as antioxidative, anti-inflammatory, anticancer, neuroprotective, and cardioprotective effects. Recent research has focused on the potential of polyphenols as alternative treatments for cardiac remodeling following cardiovascular diseases. Through a systematic search of online databases, it was found that polyphenols regulate vital molecules and signaling pathways associated with heart failure, such as fibrotic and hypertrophic factors, mitochondrial dysfunction, free radical production, apoptosis, and lipid profile and cellular metabolism. This study aims to provide a comprehensive review of the underlying mechanisms of different polyphenol subclasses in cardiac hypertrophy and heart failure, as well as investigate nano-drug delivery methods to optimize treatment outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Mina Homayoonfal, Hamidreza Gilasi, Zatollah Asemi, Mahmood Khaksary Mahabady, Reza Asemi, Bahman Yousefi
Summary: In recent decades, natural compounds have shown great potential in preventing and treating chronic diseases such as cancer. Quercetin, a bioactive flavonoid, has high pharmacological value and health-promoting effects due to its antioxidant and anti-inflammatory properties. Both in vitro and in vivo studies have confirmed that Quercetin has significant potential in cancer prevention and development. It exerts its anticancer effects by influencing various cellular processes and regulating signaling pathways and non-coding RNAs. This review aims to summarize the impact of Quercetin on molecular pathways and non-coding RNAs in modulating cancer-associated cellular mechanisms.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Alireza Mafi, Atoosa Keshavarzmotamed, Neda Hedayati, Zahra Yeganeh Boroujeni, Russel J. Reiter, Rohollah Mousavi Dehmordi, Mohammad Hossein Aarabi, Malihe Rezaee, Zatollah Asemi
Summary: Despite being mainly known as a regulator of circadian rhythm, melatonin has been found to play a notable role in other fundamental biological processes. It has been shown to have an inhibitory effect on tumor development, making it a potential adjunct agent for cancer treatment. In addition, melatonin has been found to impact the expression of non-coding RNAs (ncRNAs) in various disorders, including cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
