Article
Biology
Gaston Amable, E. duardo Martinez-Leon, Maria E. Picco, Osvaldo Rey
Summary: Metformin, a widely prescribed antidiabetic drug, has a protective effect on different cancers including colorectal cancer. Recent studies have shown that metformin at concentrations compatible with those detected in human intestines inhibits key molecules and signaling pathways associated with colorectal cancer development.
Article
Cell Biology
Qing Xiao, Jiani Xiao, Jiaqi Liu, Jiaxin Liu, Guang Shu, Gang Yin
Summary: This study discovered that metformin inhibits the proliferation of colorectal cancer cells by targeting INHBA and blocking TGF-beta/PI3K/Akt signaling, and confirmed the role of INHBA as an oncogene and its correlation with poor prognosis in colorectal cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Cassio Dejair Fleming-de-Moraes, Murilo Ramos Rocha, Josiane Weber Tessmann, Wallace Martins de Araujo, Jose Andres Morgado-Diaz
Summary: The interaction between PI3K/Akt and Wnt/β-catenin pathways contributes to colorectal cancer progression, promoting cell migration and proliferation. Reversal of these events using a PI3K inhibitor offers potential targeted therapies for colorectal cancer patients.
CANCER BIOLOGY & THERAPY
(2022)
Article
Oncology
Yaqi Tang, Xiaoyu Yi, Xinyu Zhang, Baojie Liu, Yongzheng Lu, Zhifang Pan, Tao Yu, Weiguo Feng
Summary: This study aimed to investigate the effect of MC-LR on colorectal cancer cell proliferation and the underlying mechanisms. The results showed that MC-LR promoted CRC cell proliferation by activating the PI3K/Akt/Wnt/beta-catenin pathway. This study provided a novel insight into the toxicological mechanism of MC-LR.
Article
Cell Biology
Domenico Conza, Paola Mirra, Gaetano Cali, Luigi Insabato, Francesca Fiory, Francesco Beguinot, Luca Ulianich
Summary: Research suggests that metformin exerts anti-tumorigenic effects by inhibiting endometrial cancer cell growth and survival through the modulation of specific branches of the Unfolded Protein Response and the Wnt/beta-catenin pathway, independently of AMPK.
Article
Biochemistry & Molecular Biology
Junrong Liang, Lina Sun, Yujun Li, Wanning Liu, Danxiu Li, Ping Chen, Xin Wang, Juan Hui, Jinchi Zhou, Hao Liu, Tianyu Cao, Maogui Pang, Meng Guo, Xin Wang, Xiaodi Zhao, Yuanyuan Lu
Summary: This study investigated the expression and function of DKK4 in colorectal cancer (CRC). The results showed that DKK4 was upregulated in CRC cell lines and tissues, and it inhibited cell metastasis by repressing the Wnt signaling pathway. Through experiments and analysis, the researchers also revealed the regulatory mechanism of DKK4 and its potential therapeutic application.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ahmed H. Ghobashi, Truc T. Vuong, Jane W. Kimani, Christopher A. Ladaika, Peter C. Hollenhorst, Heather M. O'Hagan
Summary: In colorectal cancer (CRC), active AKT phosphorylates EZH2 on serine 21, leading to the modulation of gene expression through the AKT/EZH2/beta-catenin axis. EZH2 interacts with and methylates beta-catenin, increasing its binding to chromatin and promoting transcription. Furthermore, EZH2-mediated beta-catenin trimethylation enhances its interaction with TCF1 and RNA polymerase II, resulting in significant gains in genomic regions with beta-catenin occupancy.
Article
Oncology
Shuohui Dong, Shuo Liang, Zhiqiang Cheng, Xiang Zhang, Li Luo, Linchuan Li, Wenjie Zhang, Songhan Li, Qian Xu, Mingwei Zhong, Jiankang Zhu, Guangyong Zhang, Sanyuan Hu
Summary: This study describes the abnormality of glucose metabolism in 5-FU-resistant CRC, and shows that enhanced glycolysis and pentose phosphate pathway are associated with increased HIF-1 alpha expression. HIF-1 alpha-induced glucose metabolic reprogramming imparts 5-FU resistance in CRC. HIF-1 alpha is a potential biomarker for 5-FU-resistant CRC, and targeting HIF-1 alpha in combination with 5-FU may represent an effective therapeutic strategy in 5-FU-resistant CRC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek J. Los, Thomas Klonisch, Saeid Ghavami
Summary: Glioblastoma (GBM) is a devastating type of brain tumor, and targeting the Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways, which play crucial roles in GBM progression and invasion, may provide important advancements in alternative treatment strategies for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xiao-chen Li, Shuai Wang, Xin-xin Yang, Tian-jiao Li, Jia-xing Gu, Lin Zhao, Yong-rui Bao, Xian-sheng Meng
Summary: This study aimed to investigate the treatment of colorectal cancer (CRC) using Patrinia villosa Juss. (P.V) and clarify its underlying mechanism. The results from animal models showed that P.V can reduce tumor number and diameter, improve colon cell injury, and decrease levels of CRC biomarkers. Metabolomics analysis revealed changes in endogenous metabolites, indicating that P.V modulates the glycerol phospholipid metabolites closely related to the PI3K target and PI3K/Akt signaling pathway for CRC treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Kiyotaka Hagihara, Naotsugu Haraguchi, Junichi Nishimura, Asuka Yasueda, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study revealed that PLXND1 induces EMT in colorectal cancer cells through activation of the PI3K/AKT pathway, enhancing cell migration and invasion. The inhibition of Furin can suppress EMT by blocking the binding of p61-SEMA3E to PLXND1. High expression of PLXND1 is significantly associated with poor overall survival in colorectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, Harinath Bahudhanapati, Jiejing Li, Wei-Chih Chen, Pallavi Kulkarni, Laura Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei
Summary: This study demonstrates that ADAM9 in mammals can cleave ephrin-B1 and ephrin-B2, promoting neural crest induction. The study also found that ADAM9 expression is elevated in colorectal cancer (CRC) tissues and knocking down ADAM9 inhibits the migration and invasion of CRC cells, mediated by reducing Akt kinase activity. Additionally, the study reveals differential effects of ADAM9 knockdown on Wnt signaling and mTOR signaling in different CRC cell lines.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yi Cheng, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Summary: The study found that PPM can inhibit CRC cell proliferation, induce cell apoptosis, and promote G0/G1 cell cycle arrest. Additionally, PPM's effect may be related to the PI3K/AKT signaling pathway, with minimal impact on mouse functions and enhanced anticancer effects when combined with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Shun He, Wen-Long Ye, Yu-Juan Zhang, Xiao-Qin Yang, Feng Liu, Jing-Ru Wang, Xiao-Lu Ding, Yun Yang, Ruo-Nan Zhang, Yuan-Yuan Zhao, Hai-Xia Bi, Ling-Chuan Guo, Wen-Juan Gan, Hua Wu
Summary: In this study, we found that BEST4 promotes cell proliferation and metastasis in colorectal cancer. It activates the Akt signaling pathway by binding to the regulatory subunit p85 alpha of PI3K, leading to the expression of critical regulators such as MYC and CCND1. Additionally, high expression of BEST4 is associated with poor prognosis in patients.
Article
Multidisciplinary Sciences
Maria Florencia Albertoni Borghese, Maria del Carmen Ortiz, Rocio C. Marinoni, Lucas H. Oronel, Milena Palamidessi, Carolina A. Yarza, Nicolas Di Siervi, Carlos Davio, Monica P. Majowicz
Article
Biochemistry & Molecular Biology
Angela Rodriguez Gonzalez, Ana Sahores, Antonela Diaz-Nebreda, Agustin Yaneff, Nicolas Di Siervi, Natalia Gomez, Federico Monczor, Natalia Fernandez, Carlos Davio, Carina Shayo
Summary: The study demonstrates that histamine regulates intracellular cAMP levels through histamine H-2 receptors in AML cells, inducing the expression of MRP4/ABCC4, and inhibiting AML cell proliferation by increasing cAMP efflux.
Article
Cell Biology
Gaston Amable, Eduardo Martinez-Leon, Maria Elisa Picco, Sergio Nemirovsky, Enrique Rozengurt, Osvaldo Rey
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Cintia E. Citterio, Sofia Siffo, Christian M. Moya, Mauricio Gomes Pio, Maricel F. Molina, Karen G. Scheps, Osvaldo A. Rey, Peter Arvan, Carina M. Rivolta, Hector M. Targovnik
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Cell Biology
Lucia Gargiulo, Ezequiel Mariano Rivero, Nicolas di Siervi, Edgardo David Buzzi, Mariano Gabriel Buffone, Carlos Alberto Davio, Isabel Alicia Luthy, Ariana Bruzzone
Article
Biochemistry & Molecular Biology
Juan Pablo Melana Colavita, Juan Santiago Todaro, Maximiliano de Sousa, Maria May, Natalia Gomez, Agustin Yaneff, Nicolas Di Siervi, Maria Victoria Aguirre, Carlos Guijas, Leandro Ferrini, Carlos Davio, Juan Pablo Rodriguez
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Reproductive Biology
C. E. Osycka-Salut, E. Martinez-Leon, M. G. Gervasi, L. Castellano, C. Davio, N. Chiarante, A. M. Franchi, M. L. Ribeiro, E. S. Diaz, S. Perez-Martinez
Article
Multidisciplinary Sciences
A. Sahores, A. Carozzo, M. May, N. Gomez, N. Di Siervi, M. De Sousa Serro, A. Yaneff, A. Rodriguez-Gonzalez, M. Abba, C. Shayo, C. Davio
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
Brenda Florencia Gimeno, Maria Victoria Bariani, Lucia Laiz-Quiroga, Eduardo Martinez-Leon, Micaela Von-Meyeren, Osvaldo Rey, Adrian Angel Mutto, Claudia Elena Osycka-Salut
Summary: This study improved the yield of fertilization-capable sperm from equine frozen sperm by optimizing manipulation conditions and establishing a primary culture model of oviductal cells. The in vitro model demonstrated the potential fertilizing capacity of sperm released from oviductal cells, suggesting advancements in handling and selection of cryopreserved sperm for improved efficiencies in assisted reproductive techniques.
Article
Thermodynamics
Kushal Sharma
Summary: This study focuses on the impact of viscous dissipation and nonlinear thermal radiation on the flow and heat transfer of ferrofluid past a porous rotating disk. Computational analysis is conducted using Maple software to explore the effects of various parameters. The results indicate that radial flow becomes dominant with increasing rotational speed, and the temperature of the magnetic fluid increases with higher magnetic field, viscous dissipation, and thermal radiation.
Article
Biology
Gaston Amable, E. duardo Martinez-Leon, Maria E. Picco, Osvaldo Rey
Summary: Metformin, a widely prescribed antidiabetic drug, has a protective effect on different cancers including colorectal cancer. Recent studies have shown that metformin at concentrations compatible with those detected in human intestines inhibits key molecules and signaling pathways associated with colorectal cancer development.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
