Article
Chemistry, Analytical
Caiping Ding, Yuting Gu, Weiwei Chen, Long Chen, Longhua Guo, Youju Huang
Summary: Near-infrared (NIR) fluorescent probes offer highly sensitive detection of Al3+ for human health purposes. This study introduces new Al3+ response molecules (HCMPA) and NIR upconversion fluorescent nanocarriers (UCNPs) that respond to Al3+ through ratio NIR fluorescence. The use of UCNPs improves photobleaching and addresses the lack of visible light in specific HCMPA probes. The NIR ratiometric fluorescence sensing system successfully detects Al3+ within the range of 0.1-1000 nM with an accuracy limit of 0.06 nM.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Jiefei Wang, Shangguan Ping, Ming Lin, Libing Fu, Yisheng Liu, Lulu Han, Sudi Chen, Xiao Wang, Mengya Lu, Zhengqun Luo, Yong Zhong, Bingyang Shi, Feng Bai
Summary: This study designed a brain-targeting NIR theranostic system with a dual-site FRET route and superior spectral matching to maximize the energy utilization for synergistic photodynamic and photothermal therapy of glioma. The system efficiently triggers the synergistic phototherapy ablation of glioma cells and significantly prolongs the survival of orthotopic glioma-bearing mice after traversing the BBB and targeting glioma. This success of advanced spectral modulation and dual-site FRET strategy may inspire more strategies to maximize the photoenergy utilization of UCNPs for brain diseases.
Article
Chemistry, Physical
Yuehong Zhang, Xiaohui Zhu, Jing Zhang, Yihan Wu, Jinliang Liu, Yong Zhang
Summary: Lanthanide-doped upconversion nanoparticles (UCNPs) have unique capabilities of converting near-infrared light to visible/ultraviolet emission. A study reported Nd3+-sensitized UCNPs with high concentration of Nd3+ doping (up to 50 mol%), which significantly increased the upconversion emissions upon 808 nm excitation for dual photodynamic and photothermal therapy. This novel nanoplatform can solve overheating issue associated with 980 nm light excitation and significantly improve cancer therapy efficacy through synergistic therapeutic effect.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Rachel Langenbacher, Januka Budhathoki-Uprety, Prakrit Jena, Daniel Roxbury, Jason Streit, Ming Zheng, Daniel A. Heller
Summary: Applications of single-walled carbon nanotubes in bioimaging and biosensing have been limited by difficulties in preparing single-chirality nanotubes with desired functionalities. Researchers developed subcellular SWCNT imaging probes and explored internanotube FRET in live cells. This work suggests the potential use of single-chirality carbon nanotubes in biomedical research.
Article
Nanoscience & Nanotechnology
Connor Riahin, Adam Meares, Nopondo N. Esemoto, Marcin Ptaszek, Michael LaScola, Narendra Pandala, Erin Lavik, Mengran Yang, Gary Stacey, Dehong Hu, Jeremiah C. Traeger, Galya Orr, Zeev Rosenzweig
Summary: This paper presents a method for synthesizing near-infrared emitting polymer dots (Pdots) with tunable emission peak wavelength by doping chlorins and bacteriochlorins. The doped Pdots show nearly spherical morphology with narrow emission bands. The paper demonstrates the utility of this synthesis approach and showcases the potential applications of Pdots in various fields.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chuangui Sheng, Fangzhi Yu, Youming Feng, Ming Gao, Wei Li, Lele Li, Jian Zhao
Summary: Metal-organic frameworks (MOFs) are used as a promising platform for protein delivery due to their high loading capacity and tunable functionality. However, the controlled release of proteins from MOFs-based nanocarriers is still a challenge. In this study, a MOFs-based protein delivery system that can precisely control protein release using near-infrared (NIR) light is reported. The system involves the encapsulation of proteins and upconversion nanoparticles (UCNPs) within MOFs and the use of NIR light to trigger the release of the proteins.
Article
Chemistry, Analytical
Yan Gong, Wei Yuan, Peng Zhang, Ke Zheng, Qian Zhang, Caifeng Ding
Summary: A smart nano platform was constructed by loading upconversion nanoparticles (UCNPs) with photosensitizers Ce6, which can specifically light up tumor tissues and stimulate reactive oxygen species (ROS) production under near-infrared (NIR) irradiation, showing remarkable fluorescence imaging and photodynamic therapy (PDT) effect for deep tumors. The judicious introduction of anti-fouling peptide improved the PDT efficiency and obtained an excellent anti-fouling performance in complex biological substrate. By modifying polypeptide targeting for HER2, the nanoplatform achieved specificity to malignant breast cancer cells. This anti-fouling nanoplatform provides a new approach for the development of fluorescence imaging and PDT for deep tumor tissue with high targeting and therapeutic efficacy, promising to be used in the early therapy of malignant breast cancer specifically.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Applied
Jinjin Zhang, Qi Chen, Yiqi Fan, Huayu Qiu, Zhigang Ni, Yang Li, Shouchun Yin
Summary: The study introduces a novel NIR fluorescent material TTBE, which exhibits solvatochromism and aggregation-induced emission characteristics, demonstrating NIR emission in water through the construction of nanoparticles and showing excellent cytocompatibility.
Article
Chemistry, Multidisciplinary
Rui Luo, Chunqing Ou, Xinchao Li, Yanfang Wang, Wei Du, Gaolin Liang, Changyang Gong
Summary: In this study, a molecular probe was synthesized using a CBT-Cys click condensation reaction to initiate the disassembly of self-assembled nanoparticles in response to tumor acidity, achieving tumor-targeted imaging.
Article
Chemistry, Analytical
Yanyan Ma, Yongyuan Liu, Zike Jiang, Hongmin Lv, Jing Wang, Tao Wang, Xiaonan Zhang, Yimeng Hu, Haitao Lin, Weiying Lin
Summary: An NIR fluorescent probe was developed for real-time and in-situ imaging of pH changes in the stomach, aiding in the diagnosis and treatment of various gastric diseases. The probe showed potential for imaging-guided diagnostics and therapeutics of gastric diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng Zhong, Hongjie Dai
Summary: This study utilized artificial neural networks to transform fluorescence images in the shorter-wavelength NIR window to images resembling NIR-IIb window, achieving high signal-to-background ratio in vivo lymph node imaging with human-approved molecular probes. Translation of PD-L1 or EGFR imaging greatly enhanced tumor-to-normal tissue ratio and improved tumor margin localization, showcasing the potential of deep learning in enhancing noninvasive NIR imaging and microscopy. Deep learning equipped NIR imaging could facilitate basic biomedical research and clinical diagnostics and imaging-guided surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Wen-Jing Shi, Yong-Feng Wei, Jinrong Yang, Hui-Zhi Li, Qing-Hui Wan, Yuxuan Wang, Huaxiang Leng, Kun Chen, Jin-wu Yan
Summary: This manuscript presents two novel monostyryl boron dipyrromethenes (BODIPYs) as highly sensitive and near-infrared-emitting fluorescent probes for imaging cellular viscosity. These probes exhibit low detection limits, show good linear relationship, and have no cytotoxicity in cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Pharmacology & Pharmacy
Fei Ding, Jing Feng, Xueli Zhang, Jielin Sun, Chunhai Fan, Zhilei Ge
Summary: Optical imaging is crucial in biomedicine and theragnostic, but faces limitations in deep-tissue visualization due to light scattering and tissue autofluorescence. Responsive optical probes are designed for precise diagnosis and surgery excision by specific reactions with biological analytes or disease biomarkers.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Analytical
Chao Jiang, Shining Li, Chuang Liu, Ruiyuan Liu, Jinqing Qu
Summary: A NIR cationic fluorescent probe PCTP with D-pi-A structure and large Stokes shift was designed and synthesized, which can differentiate RNA from DNA with high selectivity and sensitivity. The probe shows potential applications in RNA imaging and long-term cellular tracing.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Engineering, Biomedical
Doudou Hu, Dongdong Li, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: This paper discusses the potential of vanadium compounds in cancer treatment and the advantages of vanadium-based nanomaterials as a multimodal platform, as well as their synthesis routes and applications as therapeutic and diagnostic agents for tumors.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yanting Yu, Keqi Xiang, Mingzhi Xu, Yuqiang Li, Jiajunzi Cui, Lanqiong Zhang, Xiaohu Tang, Xianqi Zhu, Lili Qian, Meng Zhang, Yan Yang, Qingsong Yu, Youqing Shen, Zhihua Gan
Summary: The intercellular connections in the tumor microenvironment are considered to be the driving force for acquired drug resistance and proliferative burst, presenting a major obstacle in cancer treatment.
Review
Materials Science, Multidisciplinary
He Ma, Song Wang, Bing Yu, Xin Sui, Youqing Shen, Hailin Cong
Summary: Bio-nanochannels in living organisms selectively transport ions through cell membranes and inspire the development of artificial ion nanochannels. Polymer-based biomimetic nanochannels offer good mechanical stability, high-performance ion transport, and designability. This review mainly focuses on the fabrication and application of polymer-based biomimetic nanochannels, especially in environmentally responsive biosensor and energy conversion.
SCIENCE CHINA-MATERIALS
(2021)
Review
Engineering, Biomedical
Yingbin Su, Bing Yu, Song Wang, Hailin Cong, Youqing Shen
Summary: In recent years, there has been an active exploration of new imaging methods with high biological imaging performance, particularly in the NIR-II region. The use of small organic molecule fluorophores has attracted attention due to their good biocompatibility properties, showing promise for future developments in imaging research.
Review
Chemistry, Multidisciplinary
Shuaibing Guo, Bing Yu, Fengyuan Gao, Song Wang, Youqing Shen, Hailin Cong
Summary: Three-dimensional colloidal crystal materials have unique optical properties and spatial structure, with potential for preparing three-dimensionally ordered microporous materials. This review covers various preparation methods, effects of parameters on assembly, and main applications of 3DCCs.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jing Liu, Zhihao Zhao, Nasha Qiu, Quan Zhou, Guowei Wang, Haiping Jiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: In this study, it was found that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces PD-L1 expression in cancer cells and enhances doxorubicin-induced immunogenic cell death, promoting T cell infiltration and reducing tumor growth in preclinical models.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Qingye Meng, Shuangling Zhong, Shihao He, Yan Gao, Xuejun Cui
Summary: In this study, eco-friendly, biodegradable, and biocompatible carboxymethyl cellulose (CMC) was used to design folic acid modified pH and reduction dual-responsive microcapsules for targeted delivery and release of curcumin (CUR). The excess drug and solvent could be recycled, showing good biocompatibility and anti-tumor effects. This smart delivery system has the potential for clinical applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Applied
Yongyan Yang, Lifeng Xu, Jingfei Wang, Qingye Meng, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Hydrogels are polymer materials with three-dimensional networks that can absorb a large amount of water and biological fluids. Self-healing hydrogels, due to their good biocompatibility and biodegradability, have great potential applications in tissue engineering, wound dressings, drug delivery, and other fields.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Applied
Qingye Meng, Shuangling Zhong, Lifeng Xu, Jingfei Wang, Zhenqian Zhang, Yan Gao, Xuejun Cui
Summary: This review summarizes several latest designs of polysaccharide-based drug carriers and focuses on the latest design strategies and considerations of drug carriers with polysaccharides as the main structure. It provides design ideas and inspiration for subsequent polysaccharide-based drug delivery systems.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Shihao He, Qingye Meng, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Smart drug carriers with targeted delivery and controlled release ability, such as the FA-RANCs developed in this study, have shown promising potential for delivering and releasing hydrophobic anti-cancer drugs in a controlled manner.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Qingye Meng, Shuangling Zhong, Yan Gao, Xuejun Cui
Summary: Polysaccharide-based nano/microcapsules, with their good encapsulation ability and tunability, have been widely used in biomedical applications such as drug delivery, gene therapy, wound dressings, and bioimaging. This review discusses the latest research strategies and design considerations, summarizes the preparation methods and application strategies of polysaccharide-based nano/microcapsules, and explores their challenges and future prospects in biomedicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Applied
Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui
Summary: Chitosan-based microcapsules have gained attention for their natural, non-toxic, biocompatible, and biodegradable properties, and have shown great practical application potential in the biomedical and food science fields.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Qingye Meng, Liping Zhou, Shuangling Zhong, Jingfei Wang, Jia Wang, Yan Gao, Xuejun Cui
Summary: Polysaccharide materials, such as modified starch-based nanocapsules, have shown great potential in the biomedical field due to their biocompatible and biodegradable properties. In this study, starch was modified and loaded with curcumin to prepare FARSNCs@CUR. The nanocapsules exhibited stable particle size distribution and showed promising drug release behavior in vitro. Furthermore, they demonstrated good biocompatibility, protective effects on normal cells, and antibacterial properties. These findings suggest that FARSNCs@CUR could be used in various applications, including food preservation and wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Qingye Meng, Shuangling Zhong, Jia Wang, Yan Gao, Xuejun Cui
Summary: In this study, glutathione (GSH)-responsive microcapsules were prepared for controlled and accurate drug release. The microcapsules exhibited cascade-response release properties in the tumor microenvironment, releasing the drug in a stepwise manner. The strategy showed good anti-tumor ability and protection of normal cells, enhancing the accuracy and safety of targeted drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Xueping Wang, Yongyan Yang, Shuangling Zhong, Qingye Meng, Yiwei Li, Jia Wang, Yan Gao, Xuejun Cui
Summary: The heavy use of conventional fertilizers can have negative environmental consequences, thus the development and use of controlled-release fertilizers (CRFs) has become necessary. This review provides an overview of the classification, raw material composition, benefits, release process, release mode, and manufacturing methods of fertilizers coated with organic-inorganic composite membranes (OICMs), offering insights into the future trends in the field. It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.