Ascorbate promotes the cellular accumulation of doxorubicin and reverses the multidrug resistance in breast cancer cells by inducing ROS-dependent ATP depletion

Energy Metabolism Drugs Block Triple Negative Breast Metastatic Cancer Cell Phenotype

(2018) Silvia Cecilia Pacheco-Velázquez et al.   MOLECULAR PHARMACEUTICS

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

(2018) Guo-Xin Hou et al.   Cell Death & Disease

Redox active metals and H 2 O 2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models

(2018) Joshua D. Schoenfeld et al.   Redox Biology

Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis

(2017) Enlong Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanoscale quantification of the biophysical characterization of combretastatin A-4-treated tumor cells using atomic force microscopy

(2017) Yanchun Li et al.   PLoS One

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

Molecular mechanisms for tumour resistance to chemotherapy

(2016) Shu-Ting Pan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

(2016) Lauren Rouleau et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP 5+ /Ascorbate System

(2016) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of intrinsic and extrinsic apoptosis through oxidative stress in drug-resistant cancer by a newly synthesized Schiff base copper chelate

(2016) Kaushik Banerjee et al.   FREE RADICAL RESEARCH

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

(2016) Claire M. Doskey et al.   Redox Biology

Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties

(2015) Miao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Breast Cancer Resistance Protein and P-Glycoprotein Influence In Vivo Disposition of 11C-Erlotinib

(2015) A. Traxl et al.   JOURNAL OF NUCLEAR MEDICINE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy

(2015) Masayuki Fukui et al.   PLANTA MEDICA

Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

(2015) Y Hu et al.   Cell Death & Disease

Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway

(2014) Ting Chen et al.   CANCER BIOLOGY & THERAPY

Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death

(2014) Christopher Del Nagro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coencapsulated Doxorubicin and Bromotetrandrine Lipid Nanoemulsions in Reversing Multidrug Resistance in Breast Cancer in Vitro and in Vivo

(2014) Xi Cao et al.   MOLECULAR PHARMACEUTICS

Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin

(2013) Tae Hyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

(2013) Myron K. Evans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress

(2012) Julien Verrax et al.   Anti-Cancer Agents in Medicinal Chemistry

Pegylated Phosphotidylethanolamine Inhibiting P-Glycoprotein Expression and Enhancing Retention of Doxorubicin in MCF7/ADR Cells

(2011) Jing Wang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE