Challenges in the development of egg-independent vaccines for influenza

Improving influenza vaccines: challenges to effective implementation

(2018) Fan Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Comparison of haemagglutination inhibition, Single Radial Haemolysis, virus neutralization and ELISA assays TO detect antibody levels against seasonal influenza viruses

(2018) Claudia Maria Trombetta et al.   Influenza and Other Respiratory Viruses

Production of complex viral glycoproteins in plants as vaccine immunogens

(2018) Emmanuel Margolin et al.   PLANT BIOTECHNOLOGY JOURNAL

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production

(2018) Daniela P. Sequeira et al.   VACCINE

H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation

(2018) James D. Allen et al.   Human Vaccines & Immunotherapeutics

Cell culture-derived flu vaccine: Present and future

(2018) Alberto Pérez Rubio et al.   Human Vaccines & Immunotherapeutics

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

(2018) Daniela S. Rajão et al.   Frontiers in Microbiology

A Review of DNA Vaccines Against Influenza

(2018) Leo Yi Yang Lee et al.   Frontiers in Immunology

Influenza

(2018) Florian Krammer et al.   Nature Reviews Disease Primers

MAb-based competitive ELISA for the detection of antibodies against influenza D virus

(2018) Ana Moreno et al.   Transboundary and Emerging Diseases

A naturally protective epitope of limited variability as an influenza vaccine target

(2018) Craig P. Thompson et al.   Nature Communications

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Cell culture-derived influenza vaccines in the severe 2017–2018 epidemic season: a step towards improved influenza vaccine effectiveness

(2018) Ian G. Barr et al.   npj Vaccines

Comparing influenza vaccine types: the path towards improved influenza vaccine strategies

(2018) Brendan Flannery et al.   JOURNAL OF INFECTIOUS DISEASES

DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial

(2018) Katherine V. Houser et al.   PLoS One

Production of virus-like particles for vaccines

(2017) J. Fuenmayor et al.   New Biotechnology

Major findings and recent advances in virus–like particle (VLP)-based vaccines

(2017) Mona O. Mohsen et al.   SEMINARS IN IMMUNOLOGY

Announcing the publication of the WHO immunological basis for immunization series module on influenza vaccines

(2017) Justin R. Ortiz et al.   VACCINE

Improving the selection and development of influenza vaccine viruses – Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18–20 November 2015

(2017) Alan Hampson et al.   VACCINE

Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets

(2017) Gale E. Smith et al.   VIROLOGY

Comparison between MDCK and MDCK-SIAT1 cell lines as preferred host for cell culture-based influenza vaccine production

(2016) Asghar Abdoli et al.   BIOTECHNOLOGY LETTERS

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Influenza immunology evaluation and correlates of protection: a focus on vaccines

(2016) Claudia Maria Trombetta et al.   Expert Review of Vaccines

An overview of the regulation of influenza vaccines in the United States

(2016) Jerry P. Weir et al.   Influenza and Other Respiratory Viruses

Fluzone® intra-dermal (Intanza®/Istivac® Intra-dermal): An updated overview

(2016) Nicola Luigi Bragazzi et al.   Human Vaccines & Immunotherapeutics

Influenza Vaccines: Challenges and Solutions

(2015) Katherine Houser et al.   Cell Host & Microbe

Influenza Plasmid DNA Vaccines: Progress and Prospects

(2015) Diana Bicho et al.   CURRENT GENE THERAPY

Current and next generation influenza vaccines: Formulation and production strategies

(2015) Peter C. Soema et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Flucelvax (Optaflu) for seasonal influenza

(2015) Ilaria Manini et al.   Expert Review of Vaccines

DNA Priming for Seasonal Influenza Vaccine: A Phase 1b Double-Blind Randomized Clinical Trial

(2015) Julie E. Ledgerwood et al.   PLoS One

Strengthening the influenza vaccine virus selection and development process

(2015) William K. Ampofo et al.   VACCINE

Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets

(2015) S. Pillet et al.   VACCINE

Comparison of immunogenicity of cell-and egg-passaged viruses for manufacturing MDCK cell culture-based influenza vaccines

(2015) Duckhyang Shin et al.   VIRUS RESEARCH

Development of high-yield influenza A virus vaccine viruses

(2015) Jihui Ping et al.   Nature Communications

Live attenuated influenza vaccine for children with egg allergy

(2015) Matthew Greenhawt   BMJ-British Medical Journal

The development and manufacture of influenza vaccines

(2015) Barry C Buckland   Human Vaccines & Immunotherapeutics

Cell culture-based influenza vaccines: A necessary and indispensable investment for the future

(2015) Nagendra R Hegde   Human Vaccines & Immunotherapeutics

Current and Emerging Cell Culture Manufacturing Technologies for Influenza Vaccines

(2015) Ernest Milián et al.   Biomed Research International

Live attenuated influenza vaccine for children with egg allergy

(2015) Matthew Greenhawt   BMJ-British Medical Journal

Cocirculation of Two Distinct Genetic and Antigenic Lineages of Proposed Influenza D Virus in Cattle

(2014) Emily A. Collin et al.   JOURNAL OF VIROLOGY

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Technology transfer and scale-up of the Flublok® recombinant hemagglutinin (HA) influenza vaccine manufacturing process

(2014) Barry Buckland et al.   VACCINE

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

(2014) B. M. Hause et al.   mBio

Toward a Universal Influenza Virus Vaccine: Prospects and Challenges

(2013) Natalie Pica et al.   Annual Review of Medicine

Traditional and New Influenza Vaccines

(2013) S.-S. Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

Influenza virosomes as vaccine adjuvant and carrier system

(2013) Christian Moser et al.   Expert Review of Vaccines

Immunological assessment of influenza vaccines and immune correlates of protection

(2013) Adrian Reber et al.   Expert Review of Vaccines

A pandemic H1N1 influenza virus-like particle vaccine induces cross-protection in mice

(2013) Kyung-Soo Inn et al.   IMMUNOLOGICAL INVESTIGATIONS

Influenza vaccine safety in patients with egg allergy

(2013) Katie A. Croegaert et al.   JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

The prospects and challenges of universal vaccines for influenza

(2013) Kanta Subbarao et al.   TRENDS IN MICROBIOLOGY

Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

(2013) Gale E. Smith et al.   VACCINE

Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults

(2013) James F. Cummings et al.   VACCINE

Influenza Virus Reassortment Occurs with High Frequency in the Absence of Segment Mismatch

(2013) Nicolle Marshall et al.   PLoS Pathogens

A Cell Culture-Derived Influenza Vaccine Provides Consistent Protection Against Infection and Reduces the Duration and Severity of Disease in Infected Individuals

(2012) H. J. Ehrlich et al.   CLINICAL INFECTIOUS DISEASES

Cell culture-derived influenza vaccines from Vero cells: a new horizon for vaccine production

(2012) Emanuele Montomoli et al.   Expert Review of Vaccines

Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

(2012) Jessica Chichester et al.   Viruses-Basel

Virus-like particle (VLP)-based vaccines for pandemic influenza

(2012) Constantino López-Macías   Human Vaccines & Immunotherapeutics

The rationale for quadrivalent influenza vaccines

(2012) Christopher S. Ambrose et al.   Human Vaccines & Immunotherapeutics

Virus-Like Particle Vaccine Containing Hemagglutinin Confers Protection against 2009 H1N1 Pandemic Influenza

(2011) M. Jaber Hossain et al.   Clinical and Vaccine Immunology

The future of cell culture-based influenza vaccine production

(2011) Michael L Perdue et al.   Expert Review of Vaccines

Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza

(2011) Yoko Shoji et al.   Human vaccines & immunotherapeutics

A plant-based system for rapid production of influenza vaccine antigens

(2011) Yoko Shoji et al.   Influenza and Other Respiratory Viruses

Epidemiology of food allergy

(2011) Scott H. Sicherer   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

H5N1 Virus-Like Particle Vaccine Elicits Cross-Reactive Neutralizing Antibodies That Preferentially Bind to the Oligomeric Form of Influenza Virus Hemagglutinin in Humans

(2011) S. Khurana et al.   JOURNAL OF VIROLOGY

Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial

(2011) P Noel Barrett et al.   LANCET

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Evaluation of the safety, reactogenicity and immunogenicity of FluBlok® trivalent recombinant baculovirus-expressed hemagglutinin influenza vaccine administered intramuscularly to healthy adults 50–64 years of age☆

(2011) R. Baxter et al.   VACCINE

Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlok®) against influenza in healthy adults: A randomized, placebo-controlled trial

(2011) John J. Treanor et al.   VACCINE

Clinical development of a Vero cell culture-derived seasonal influenza vaccine

(2011) Hartmut J. Ehrlich et al.   VACCINE

Isolation of influenza viruses in MDCK 33016PF cells and clearance of contaminating respiratory viruses

(2011) Bernhard Roth et al.   VACCINE

Validation of the safety of MDCK cells as a substrate for the production of a cell-derived influenza vaccine

(2010) David Onions et al.   BIOLOGICALS

Cell Culture–Derived Influenza Vaccines: Has Their Time Come?

(2010) David I. Bernstein   CLINICAL INFECTIOUS DISEASES

Human influenza vaccines and assessment of immunogenicity

(2010) Zichria Zakay-Rones   Expert Review of Vaccines

Transient expression systems for plant-derived biopharmaceuticals

(2010) Tatiana V Komarova et al.   Expert Review of Vaccines

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses

(2010) Aseem Pandey et al.   Human vaccines & immunotherapeutics

Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms

(2010) Stéphane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza Vaccines for the Future

(2010) Linda C. Lambert et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Children as a Function of Time Postvaccination

(2010) Christopher S. Ambrose et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response

(2010) Zhongying Chen et al.   VACCINE

Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus

(2010) Peter Pushko et al.   VACCINE

Using plant cells as influenza vaccine substrates

(2009) Jessica A Chichester et al.   Expert Review of Vaccines

Continuous cell lines as a production system for influenza vaccines

(2009) Yvonne Genzel et al.   Expert Review of Vaccines

Safety and Immunogenicity of a Novel Influenza Subunit Vaccine Produced in Mammalian Cell Culture

(2009) Agnieszka Szymczakiewicz‐Multanowska et al.   JOURNAL OF INFECTIOUS DISEASES

Subunit Influenza Vaccines Produced from Cell Culture or in Embryonated Chicken Eggs: Comparison of Safety, Reactogenicity, and Immunogenicity

(2009) Keith S. Reisinger et al.   JOURNAL OF INFECTIOUS DISEASES

Eleven years of Inflexal® V—a virosomal adjuvanted influenza vaccine

(2009) Christian Herzog et al.   VACCINE

A phase I clinical trial of a PER.C6® cell grown influenza H7 virus vaccine

(2009) Rebecca J. Cox et al.   VACCINE

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

(2009) Suzanne Jones et al.   VACCINE

FDA guidance on prophylactic DNA vaccines: Analysis and recommendations

(2009) Dennis M. Klinman et al.   VACCINE

Plants as biofactories

(2008) Vadim Mett et al.   BIOLOGICALS

Recent progress in the development of plant derived vaccines

(2008) Vidadi Yusibov et al.   Expert Review of Vaccines

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

MDCK-SIAT1 Cells Show Improved Isolation Rates for Recent Human Influenza Viruses Compared to Conventional MDCK Cells

(2008) D. Y. Oh et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

(2008) Rick A. Bright et al.   PLoS One

Plant-expressed HA as a seasonal influenza vaccine candidate

(2008) Yoko Shoji et al.   VACCINE

A quantitative risk assessment of exposure to adventitious agents in a cell culture-derived subunit influenza vaccine

(2008) Jens-Peter Gregersen   VACCINE

A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs

(2008) Fu Shi Quan et al.   VACCINE

Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza

(2008) Yoko Shoji et al.   VACCINE

Purification and cDNA cloning of a novel protease inhibitor secreted into culture supernatant by MDCK cells

(2007) Kiyoto Nishiyama et al.   BIOLOGICALS