Article
Biotechnology & Applied Microbiology
Pau Herrero, Richard C. Wilson, Ryan Armiger, Jason A. Roberts, Alison Holmes, Pantelis Georgiou, Timothy M. Rawson
Summary: This paper investigates whether closed-loop control can improve pharmacokinetic-pharmacodynamic target attainment of piperacillin-tazobactam in critically-ill patients. The study finds that a PID controller driven by ISF drug concentration measurements significantly improves target attainment compared to traditional infusion methods.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Michael Nikolaou, Vincent H. Tam
Summary: This paper presents a novel integrated methodology for rapid assessment of antimicrobial drug efficacy under clinically relevant pharmacokinetic conditions. The methodology involves automated collection of time-kill data, processing of the data using a mathematical model to determine optimal dosing regimens, and in vitro validation in a hollow fiber system. Proof-of-concept is provided through several in vitro studies, and future directions for refinement are discussed.
Article
Infectious Diseases
Marcus Tindall, Michael J. Chappell, James W. T. Yates
Summary: Mathematical modelling has played a significant role in optimizing the use of antimicrobial treatments. This article discusses the key processes that should be captured by such modelling, with a particular emphasis on quantifying the response of the host immune system and presenting a novel model structure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Pharmacology & Pharmacy
Mary E. E. Palmer, Lauren J. J. Andrews, Taylor C. C. Abbey, Ashley E. E. Dahlquist, Eric Wenzler
Summary: A deep understanding of pharmacokinetic and pharmacodynamic properties is crucial for optimizing drug use and increasing the chances of successful drug development. Recent advances in pharmacokinetic and pharmacodynamic studies have renewed confidence in their value and made them a fundamental component of drug development programs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Patrycja Zalas-Wiecek, Katarzyna Plachta, Eugenia Gospodarek-Komkowska
Summary: Cefiderocol is a novel siderophore cephalosporin that shows potential activity against multi-drug resistant and extensively drug-resistant Enterobacterales. The study evaluated its in vitro susceptibility against clinical isolates of MDR and XDR E. coli, and found that Cefiderocol exhibited high susceptibility, making it a promising therapeutic option for the treatment of carbapenem-resistant E. coli strains.
Review
Biochemistry & Molecular Biology
Ellen Niederberger, Michael J. Parnham
Summary: Lifestyle changes, particularly through exercise and diet, can impact physiological functions in the human body. Physiological changes induced by exercise and modified diet have the potential to affect the efficacy and toxicity of drugs. This impact may play an important role in common drugs with a narrow therapeutic window.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Jennifer L. Halleran, Ryker Minch, Hannah J. Slyvester, Megan E. Jacob, Timo Prange, Ronald Baynes, Derek M. Foster
Summary: This study characterized the pharmacokinetics of different dosing regimens of florfenicol and assessed their impact on resistant indicator bacteria. It found high penetration of florfenicol in the gastrointestinal tract and no significant difference in the proportion or persistence of resistant isolates between dosing groups. The recommendation to use lower tier antimicrobials like florfenicol may allow for the persistence of co-resistance to antibiotics of high regulatory concern.
Review
Pharmacology & Pharmacy
Alicia Rodriguez-Gascon, Maria angeles Solinis, Arantxa Isla
Summary: PK/PD analysis is essential in establishing rational dosage regimens of antimicrobial agents in human and veterinary medicine. It involves the use of different models and mathematical models to determine optimal dosing regimens and prevent the emergence of resistance. PK/PD analysis plays a crucial role in the development of new antibiotics and optimization of current drug dosage regimens.
Article
Infectious Diseases
Kaitlin A. Pruskowski
Summary: Burn injuries can alter pharmacokinetic parameters, potentially leading to subtherapeutic doses of antibiotics and antifungal agents. Further research is needed to cover systemic antimicrobial agents used in the care of burn patients in order to make appropriate dosing adjustments.
SURGICAL INFECTIONS
(2021)
Editorial Material
Pharmacology & Pharmacy
Marguerite L. Monogue, Emily L. Heil, Samuel L. Aitken, Jason M. Pogue
Summary: Research compared the roles of piperacillin-tazobactam and ceftolozane-tazobactam against ESBL-producing organisms, with limited data suggesting a potential role for ceftolozane-tazobactam in therapy; however, current data do not support the usage of piperacillin-tazobactam for these infections.
Article
Pharmacology & Pharmacy
Shashikant Srivastava, Tania Thomas, Dave Howe, Lesibana Malinga, Prithvi Raj, Jan-Willem Alffenaar, Tawanda Gumbo
Summary: The study showed that cefdinir has potential efficacy against both drug-susceptible and multi-drug resistant tuberculosis, with the ability to kill Mtb strains in both in vitro and pre-clinical models. The pharmacokinetic/pharmacodynamic index AUC(0-24)/MIC of 578.86 was identified as the optimal exposure for sterilizing efficacy. Further clinical validation of these findings is needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Medicinal
Anka Lucic, Philip Hinchliffe, Tika R. Malla, Catherine L. Tooke, Jurgen Brem, Karina Calvopina, Christopher T. Lohans, Patrick Rabe, Michael A. McDonough, Timothy Armistead, Allen M. Orville, James Spencer, Christopher J. Schofield
Summary: Penems have shown potential as antibacterials and beta-lactamase inhibitors, but their clinical use is limited compared to carbapenems. Faropenem, with a C-2 tetrahydrofuran ring, is resistant to some beta-lactamases. Studies on reactions of faropenem with beta-lactamases demonstrate different outcomes, suggesting further research is needed for optimizing the interactions between penems and beta-lactamases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Lucile Dheyriat, Laurent Bourguignon, Thomas Perpoint, Tristan Ferry, Sylvain Goutelle
Summary: This study evaluated the adequacy of alternative dosage regimens for ceftolozane-tazobactam and ceftazidime-avibactam in patients with renal impairment, showing that these regimens achieved PK/PD targets and were not associated with overexposure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Gunavanthi D. Boorgula, Laxmi U. M. R. Jakkula, Tawanda Gumbo, Bockgie Jung, Shashikant Srivastava
Summary: The study compared microbial kill and resistance emergence of different rifamycins in the treatment of pulmonary MAC infection. Results showed no significant difference in efficacy and resistance suppression among the three rifamycins tested, and monotherapy with rifamycins was ineffective and led to drug resistance development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Marguerite L. Monogue, Sara Giovagnoli, Caterina Bissantz, Claudia Zampaloni, David P. Nicolau
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Islam M. Ghazi, Marguerite L. Monogue, Masakatsu Tsuji, David P. Nicolau
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Pharmacology & Pharmacy
Marguerite L. Monogue, George Sakoulas, Victor Nizet, David P. Nicolau
Article
Pharmacology & Pharmacy
Islam M. Ghazi, Marguerite L. Monogue, Masakatsu Tsuji, David P. Nicolau
Article
Public, Environmental & Occupational Health
Marguerite L. Monogue, Jessica K. Ortwine, Wenjing Wei, Khalid Eljaaly, Kavita P. Bhavan
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2018)
Article
Microbiology
Sean M. Stainton, Marguerite L. Monogue, Masakatsu Tsuji, Yoshinori Yamano, Roger Echols, David P. Nicolau
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Microbiology
Marguerite L. Monogue, Jennifer Tabor-Rennie, Kamilia Abdelraouf, David P. Nicolau
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Microbiology
Marguerite L. Monogue, Durward Watson, Julie S. Alexander, Dominick Cavuoti, Laura M. Doyle, Michael Zhuo Wang, Bonnie C. Prokesch
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Review
Medicine, General & Internal
James M. Sanders, Marguerite L. Monogue, Tomasz Z. Jodlowski, James B. Cutrell
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Immunology
Yi Kee Poon, Ricardo M. La Hoz, Linda S. Hynan, James Sanders, Marguerite L. Monogue
Summary: For the treatment of NTM infections in solid organ transplant recipients, there was no significant safety benefit of tedizolid over linezolid. Both tedizolid and linezolid-containing regimens showed a potential benefit in symptomatic and microbiologic improvement. Larger cohorts are needed to further clarify the comparative role of linezolid and tedizolid in the treatment of NTM infections in SOT recipients.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marc D. Esquivel, Marguerite L. Monogue, Greg S. Smith, James D. Finklea, James M. Sanders
Summary: This retrospective observational cohort study compared the safety and efficacy of ceftaroline with vancomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-mediated acute pulmonary exacerbations (APEs) in adult cystic fibrosis (CF) patients. The study found that ceftaroline was a viable alternative treatment option for MRSA-mediated APEs in adult CF patients, with similar outcomes to vancomycin.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Daniel N. Maxwell, Jiwoong Kim, Christine A. Pybus, Leona White, Richard J. Medford, Laura M. Filkins, Marguerite L. Monogue, Meredith M. Rae, Dhara Desai, Andrew E. Clark, Xiaowei Zhan, David E. Greenberg
Summary: Polyclonal heteroresistance (PHR) is common among Pseudomonas aeruginosa in the cystic fibrosis lung, and traditional microbiological methods often fail to detect resistant subpopulations. However, whole-genome sequencing and a machine-learning association model can successfully identify resistance variants in this context.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Marguerite L. Monogue, James M. Sanders, Christine A. Pybus, Jiwoong Kim, Xiaowei Zhan, Andrew E. Clark, David E. Greenberg
Summary: This study found polyclonal and monoclonal heteroresistance (HR) to ceftolozane/tazobactam in Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients, with approximately one-fourth of the samples showing discrepancies in ceftolozane/tazobactam susceptibility between laboratory results and clinical reports. No known resistance genes were found in the HR isolates, suggesting the limitations of traditional susceptibility testing methods in CF specimens.
JAC-ANTIMICROBIAL RESISTANCE
(2023)
Article
Pharmacology & Pharmacy
Marguerite L. Monogue, Safa S. Almarzoky Abuhussain, Joseph L. Kuti, David P. Nicolau
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2018)