LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis

LCZ696 (Sacubitril/Valsartan), an Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease

(2018) Yasunori Suematsu et al.   JOURNAL OF CARDIAC FAILURE

Telmisartan and thiorphan combination treatment attenuates fibrosis and apoptosis in preventing diabetic cardiomyopathy

(2018) Vajir Malek et al.   CARDIOVASCULAR RESEARCH

Inhibition of JNK and p38 MAPK-mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin-induced diabetic cardiomyopathy

(2018) Guangfeng Zuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle

(2017) Yang Lee et al.   FASEB JOURNAL

LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice

(2016) Yasunori Suematsu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3β-PP2Ac-NF-κB Signaling Axis

(2016) Xiao-min Ren et al.   PLoS One

Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice

(2015) Wei Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

LCZ696 (Sacubitril/Valsartan)

(2015) G. William Dec   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose-Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

(2014) Y. Pan et al.   DIABETES

The potential role of valsartan + AHU377 (LCZ696) in the treatment of heart failure

(2013) Adriaan A Voors et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling Pathway

(2012) Irina T. Nizamutdinova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

(2012) Scott D Solomon et al.   LANCET

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase-derived superoxide Anion-induced apoptosis is mediated via the JNK-dependent activation of NF-κB in cardiomyocytes exposed to high glucose

(2011) Kun-Hsi Tsai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Oxidative stress: a key contributor to diabetic cardiomyopathyThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Madhu Khullar et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure

(2010) Tariq Hamid et al.   CARDIOVASCULAR RESEARCH

Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion

(2007) Hang Yin et al.   LIFE SCIENCES