Article
Chemistry, Multidisciplinary
Hulya Gizem Ozkan, Vanrajsinh Thakor, Hong-Gui Xu, Galyna Bila, Rostyslav Bilyy, Daria Bida, Martin Boettcher, Dimitrios Mougiakakos, Rainer Tietze, Andriy Mokhir
Summary: Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are weak points of cancer cells. Designing highly potent anticancer drugs that target both ROS and mitochondria is a valid therapeutic strategy. However, limiting the drug effects to cancer cells without affecting normal ones remains a challenge. In this study, we developed novel aminoferrocene derivatives that are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells but not normal cells, and exhibit anticancer effects in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Jaewan Jeon, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, HyeSook Youn, Sunmi Jo, BuHyun Youn, Hae Yu Kim
Summary: This article discusses the anticancer effects and advantages of platinum-based drugs used in the treatment of brain tumors, and summarizes their clinical application cases and limitations. To overcome these obstacles, a novel approach to enhance the effectiveness of platinum-based drugs is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sijongesonke Peter, Sibusiso Alven, Rejoice Bethusile Maseko, Blessing Atim Aderibigbe
Summary: The scarcity of effective cancer therapeutics is a pressing issue. Doxorubicin, currently used in cancer treatment, is limited by drug resistance and toxicity. Combination with other chemotherapeutic agents is considered an effective treatment option.
Article
Pharmacology & Pharmacy
Laura Gallego-Yerga, Valentin Cena, Rafael Pelaez
Summary: The use of benzothiazole scaffold in designing colchicine site ligands has resulted in a new family of ligands with high water solubility. These ligands exhibit antiproliferative activity against various cancer cell lines, with high selectivity towards cancer cells. The most potent derivatives show nanomolar range IC50 values, even in difficult-to-treat glioblastoma cells. Flow cytometry experiments and confocal microscopy observations confirm the cell cycle arrest and apoptotic cell death induced by these ligands, which are attributed to their ability to disrupt microtubule network. Docking studies further support the interaction of the ligands at the colchicine binding site. These results validate the effective strategy of developing potent anticancer colchicine ligands with improved water solubility.
Article
Biochemistry & Molecular Biology
Xicheng Liu, Zihan Wang, Xinru Zhang, Xiaocai Lv, Yong Sun, Ruixiao Dong, Guangxiao Li, Xueyan Ren, Zhongyin Ji, Xiang-Ai Yuan, Zhe Liu
Summary: Half-sandwich IrIII-Fc heteronuclear metal complexes exhibit promising anticancer activity and possess a different mechanism from platinum-based drugs, indicating their potential as alternative agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Marta Szumilak, Anna Wiktorowska-Owczarek, Andrzej Stanczak
Summary: Hybrid drugs targeting multiple points of cancer cells have been extensively explored in recent years. They possess simpler pharmacokinetic profiles, reduce the possibility of drug interactions, and facilitate the drug development process.
Article
Biochemistry & Molecular Biology
Ahmed M. Almehdi, Sameh S. M. Soliman, Abdel-Nasser A. El-Shorbagi, Andrew D. Westwell, Rania Hamdy
Summary: This study designed and synthesized a series of indole-based compounds, and found that U2 and U3 exhibited the highest anticancer activity against MCF-7 cells and potential BCL-2 inhibition activity. Molecular docking analysis suggested stable interactions between U2 and Bcl-2 through multiple mechanisms. In addition, U2 induced apoptosis and cell cycle arrest. U2 also showed a favorable safety profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Anuradha Mehra, Vikas Sharma, Anil Verma, Sneha Venugopal, Amit Mittal, Gurdeep Singh, Balwinder Kaur
Summary: The indole moiety is a crucial nucleus in the development of anticancer drugs, with excellent pharmacological properties in targeting various proteins and enzymes. Indole-based drugs have been approved for market use as chemotherapeutics and have shown potential for cancer treatment. This study aims to review indole derivatives as anticancer agents and explore their potential derivatives under study.
Article
Pharmacology & Pharmacy
Yang Liu, Ning Zhang, Cuicui Xie, Yale Jiang, Yunhe Qin, Liyun Zhou, Yi Fan, Lianjie Ren, Chen Yin, Huan Yang, Wei Xie, Qing Zhai, Guanqiao Li, Hongzhuan Chen, Xiaoyuan Chen
Summary: China has undergone a revolution in drug regulation over the past two decades, introducing significant changes to accelerate drug review and approvals. This study provides an overview of this revolution and analyzes the impact on the landscape of drug research and development through a comprehensive analysis of newly approved anticancer drugs in China. The innovative drug development in China has greatly benefited from pro-innovation policies and expedited program designations. The number of imported and domestic new anticancer drugs has significantly increased, and the drug lag has been dramatically shortened.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Nanoscience & Nanotechnology
Jin Qi, Ran Zhang, Xiaoming Liu, Yingyu Liu, Qingmei Zhang, Huaiyi Cheng, Ran Li, Lu Wang, Xiuping Wu, Bing Li
Summary: Carbon dots (CDs) have great potential in drug delivery, especially in the treatment of inflammatory, bacterial, and cancer diseases. CDs improve cellular uptake and absorption and have controlled release properties, enhancing the therapeutic effects. They also offer advantages such as high drug-loading, increased targeting, and reduced systemic side effects. However, the safety and toxicity of CDs need to be carefully evaluated before their clinical application.
ACS APPLIED NANO MATERIALS
(2023)
Review
Oncology
Abdelhakim Bouyahya, Nasreddine El Omari, Saad Bakrim, Naoufal El Hachlafi, Abdelaali Balahbib, Polrat Wilairatana, Mohammad S. Mubarak
Summary: Several dietary phenolic compounds isolated from medicinal plants have significant anticancer effects. They induce apoptosis, autophagy, telomerase inhibition, and angiogenesis. These compounds increase the effectiveness of conventional chemotherapy drugs and have shown remarkable therapeutic results in treating certain cancers. However, chemoresistance is still a challenge in cancer treatment, and combining multiple anticancer agents can help overcome resistance and improve therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Przemyslaw Bieganski, Martina Godel, Chiara Riganti, Daniel Fabio Kawano, Joanna Kopecka, Konrad Kowalski
Summary: A library of 1,4- and 1,5-triazole ferrocenyl derivatives of erlotinib were synthesized and their anticancer activity was studied against erlotinib-sensitive and erlotinib-resistant lung cancer cells. Among the compounds investigated, two isomers showed superior activity against erlotinib-resistant cells, with a mechanism of action different from erlotinib.
BIOORGANIC CHEMISTRY
(2022)
Review
Microbiology
Jose Manuel Ezquerra-Aznarez, Pedro E. Almeida da Silva, Jose A. Ainsa
Summary: Antimicrobial resistance poses a significant challenge, pushing the need for novel drugs with new mechanisms of action. Drug repurposing has emerged as a fast, cost-effective, and efficient strategy in developing new antimicrobial agents for tuberculosis treatment.
Review
Chemistry, Applied
Guiqiu Wang, Rilun Li, Benyamin Parseh, Gang Du
Summary: Chitosan, with its advantages of being non-toxic, non-immunogenic, and biocompatible, holds great potential as a drug delivery system for treating breast cancer.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Kaiyuan Chai, Chuanlei Wang, Jianpeng Zhou, Wentao Mu, Menghan Gao, Zhongqi Fan, Guoyue Lv
Summary: Drug therapy for cancer can paradoxically enhance cell proliferation, resistance, and metastasis, leading to decreased survival. Understanding the underlying mechanisms can aid in the development of targeted therapies to optimize patient outcomes.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
G. Lohmann, E. Vasyutina, J. Bloehdorn, N. Reinart, J. I. Schneider, V. Babu, G. Knittel, G. Crispatzu, P. Mayer, C. Prinz, J. K. Muenzner, B. Biersack, D. G. Efremov, L. Chessa, C. D. Herling, S. Stilgenbauer, M. Hallek, R. Schobert, H. C. Reinhardt, B. Schumacher, M. Herling
Article
Cell Biology
Julienne K. Muenzner, Philipp Kunze, Pablo Lindner, Sandra Polaschek, Kira Menke, Markus Eckstein, Carol I. Geppert, Pithi Chanvorachote, Tobias Baeuerle, Arndt Hartmann, Regine Schneider-Stock
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Oncology
Arnatchai Maiuthed, Chuanpit Ninsontia, Katharina Erlenbach-Wuensch, Benardina Ndreshkjana, Julienne K. Muenzner, Aylin Caliskan, Husayn P. Ahmed, Chatchai Chaotham, Arndt Hartmann, Adriana Vial Roehe, Vijayalakshmi Mahadevan, Pithi Chanvorachote, Regine Schneider-Stock
Article
Biochemistry & Molecular Biology
Aamir Ahmad, Prasad Dandawate, Sebastian Schruefer, Subhash Padhye, Fazlul H. Sarkar, Rainer Schobert, Bernhard Biersack
CHEMISTRY & BIODIVERSITY
(2019)
Article
Oncology
Ana Carolina Monteiro, Julienne K. Muenzner, Fernando Andrade, Flavia Eichemberger Rius, Christian Ostalecki, Carol I. Geppert, Abbas Agaimy, Arndt Hartmann, Andre Fujita, Regine Schneider-Stock, Miriam Galvonas Jasiulionis
MOLECULAR ONCOLOGY
(2019)
Article
Cell Biology
Benardina Ndreshkjana, Aysun Capci, Volker Klein, Pithi Chanvorachote, Julienne K. Muenzner, Kerstin Huebner, Sara Steinmann, Katharina Erlenbach-Wuensch, Carol Geppert, Abbas Agaimy, Farah Bailout, Chirine El-Baba, Hala Gali-Muhtasib, Adriana Vial Roehe, Arndt Hartmann, Svetlana B. Tsogoeva, Regine Schneider-Stock
CELL DEATH & DISEASE
(2019)
Article
Oncology
Julian Boehm, Julienne Kathrin Muenzner, Aylin Caliskan, Benardina Ndreshkjana, Katharina Erlenbach-Wuensch, Susanne Merkel, Roland Croner, Tilman T. Rau, Carol Immanuel Geppert, Arndt Hartmann, Adriana Vial Roehe, Regine Schneider-Stock
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Article
Cell Biology
Sara Steinmann, Philipp Kunze, Chuanpit Hampel, Markus Eckstein, Jesper Bertram Bramsen, Julienne K. Muenzner, Birgitta Carle, Benardina Ndreshkjana, Stephan Kemenes, Pierluigi Gasparini, Oliver Friedrich, Claus Andersen, Carol Geppert, Shengbao Wang, Ilker Eyupoglu, Tobias Baeuerle, Arndt Hartmann, Regine Schneider-Stock
CELL DEATH & DISEASE
(2019)
Article
Immunology
Axel Dietschmann, Sebastian Schruefer, Sven Krappmann, David Voehringer
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Cell Biology
Pablo Lindner, Sushmita Paul, Markus Eckstein, Chuanpit Hampel, Julienne K. Muenzner, Katharina Erlenbach-Wuensch, Husayn P. Ahmed, Vijayalakshmi Mahadevan, Thomas Brabletz, Arndt Hartmann, Julio Vera, Regine Schneider-Stock
CELL DEATH & DISEASE
(2020)
Article
Chemistry, Multidisciplinary
Jing-Jing Zhang, Mohamed A. Abu el Maaty, Henrik Hoffmeister, Claudia Schmidt, Julienne K. Muenzner, Rainer Schobert, Stefan Wolfl, Ingo Ott
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Multidisciplinary Sciences
Sebastian Schruefer, Isabella Boehmer, Karl Dichtl, Anja Spadinger, Christoph Kleinemeier, Frank Ebel
Summary: The study found that the antifungal activity of fludioxonil in A. fumigatus relies on two distinct and synergistic processes: a high internal osmotic pressure and a weakened cell wall. Skn7's involvement in both processes most likely accounts for its particular importance in the antifungal activity of fludioxonil.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jurgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Summary: Eosinophilia is associated with various inflammatory diseases, such as allergic bronchopulmonary aspergillosis (ABPA). It has been shown that direct interaction between eosinophils and Aspergillus fumigatus is essential for the activation of eosinophils, which then secrete multiple proinflammatory mediators. The PI3K-AKT-mTOR pathway plays a crucial role in A. fumigatus-induced eosinophil activation.
Article
Chemistry, Medicinal
Tony Froehlich, Benardina Ndreshkjana, Julienne K. Muenzner, Christoph Reiter, Elisabeth Hofmeister, Sandra Mederer, Maamoun Fatfat, Chirine El-Baba, Hala Gali-Muhtasib, Regine Schneider-Stock, Svetlana B. Tsogoeva