GSTZ 1‐1 Deficiency Activates NRF 2/ IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate

(2016) Stephan C. Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

(2016) Jiayu Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency

(2016) Hao Yang et al.   JOURNAL OF MEDICAL GENETICS

Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1)

(2015) Ivraj Singh Sandhu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Keap1–Nrf2 signalling in pancreatic cancer

(2015) Alastair J. Hayes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment

(2015) Kunal Amratlal Lodhia et al.   Frontiers in Oncology

Nrf2 ameliorates diabetic nephropathy progression by transcriptional repression of TGFβ1 through interactions with c-Jun and SP1

(2014) Pan Gao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcriptional and epigenetic control of IGF1R gene expression: Implications in metabolism and cancer

(2014) Haim Werner et al.   GROWTH HORMONE & IGF RESEARCH

Succinylacetone as primary marker to detect tyrosinemia type I in newborns and its measurement by newborn screening programs

(2014) Víctor R. De Jesús et al.   MOLECULAR GENETICS AND METABOLISM

Serine and glycine metabolism in cancer

(2014) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Upregulation of the Insulin Receptor and Type I Insulin-Like Growth Factor Receptor Are Early Events in Hepatocarcinogenesis

(2011) Eiman Aleem et al.   TOXICOLOGIC PATHOLOGY

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development

(2008) Silke Marhenke et al.   HEPATOLOGY

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH