Article
Developmental Biology
Laura Currey, Stefan Thor, Michael Piper
Summary: The balance between stem cell potency and lineage specification relies on the integration of extrinsic and intrinsic cues to influence gene expression through transcription factors. The Hippo signalling pathway, particularly involving YAP, TAZ, and TEAD proteins, plays a key role in regulating organ size and progenitor self-renewal during development. Studies are revealing the intricate roles of TEAD proteins in maintaining the balance between stem cell self-renewal and differentiation in various developmental stages.
Article
Biochemistry & Molecular Biology
Mengfei Wang, Qin Yan, Yunfeng Song, Zhenbo Zhang, Xiaojun Chen, Kun Gao, Xiaoping Wan
Summary: This study reveals that the transcription factor SOX17 acts as a tumor suppressor in endometrial cancer by inhibiting the transcriptional outputs of the Hippo-YAP/TEAD pathway. SOX17 binds to TEAD and attenuates its DNA-binding ability. Small molecule inhibitors of YAP/TEAD or the FDA-approved drug cabozantinib can reverse the malignant transformation caused by SOX17 mutations.
Article
Toxicology
M. Chiara Perego, Benjamin D. McMichael, Lisa J. Bain
Summary: More than 150 million people are exposed to arsenic concentrations above the drinking water standard through contaminated food and water. Arsenic exposure during embryogenesis disrupts neuronal and muscle development. In this study, murine embryonic stem cells were chronically exposed to an environmentally relevant concentration of arsenic, leading to impairment of the Hippo signaling pathway involved in embryonic development and pluripotency maintenance.
TOXICOLOGY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Xia Yuan, Chen Zhang, Ruifeng Zhao, Jingyi Jiang, Xiang Shi, Ming Zhang, Hongyan Sun, Qisheng Zuo, Yani Zhang, Jiuzhou Song, Guohong Chen, Bichun Li
Summary: This study found that glycolysis was activated during the reprogramming of chicken iPSCs, and the further activation of endogenous pluripotent genes promoted the reprogramming process. The introduction of two small-molecule inhibitors in the optimized reprogramming cocktail significantly improved the efficiency of iPSC formation.
Article
Environmental Sciences
Jue Wang, Shumin Zhu, Yangtao Wu, Da Sheng, Lingjun Bu, Shiqing Zhou
Summary: UV-LED was used to investigate the effects of UV wavelength on the simultaneous removal of ClO2- and OMPs, with RCS identified as the major contributor to the degradation of CBZ. The study also identified the degradation products of CBZ and the impact of ClO2- dosage on chlorate production in the UV/ClO2- system.
Article
Environmental Sciences
Julong Sun, Shiqing Zhou, Da Sheng, Nan Li, Jue Wang, Changbo Jiang
Summary: This study investigated the degradation of BMAA by UV/chlorine process and found that it was more effective than using UV or chlorine alone. The reaction rates were increased under alkaline conditions, with BMAA being completely degraded in 5 minutes. NOM had a significant inhibitory effect on the degradation of BMAA.
Article
Chemistry, Organic
Marcelo H. R. Carvalho, Joa P. R. S. Ribeiro, Pedro P. De Castro, Saulo T. A. Passos, Brenno A. D. Neto, Helio F. Dos Santos, Giovanni W. Amarante
Summary: A synthetic protocol for the preparation of alpha-acyl aminocarboxamides and alpha-amino amidines is proposed, and the selectivity toward each of these products is tunable by modifying the reaction conditions. Theoretical calculations and mass spectrometry experiments reveal a new mechanistic pathway for the Ugi reaction, where methanol not only acts as the solvent but also as a reagent.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Raya Soltane, Ahlam Alasiri, Mostafa N. Taha, Rehab H. Abd El-Aleam, Kawthar Saad Alghamdi, Mosad A. Ghareeb, Doaa El-Ghareeb Keshek, Susana M. Cardoso, Ahmed M. Sayed
Summary: In this study, a compound called norlobaridone (NBD) was isolated from Parmotrema and found to inhibit the biofilm development and related virulence factors of Pseudomonas aeruginosa. Further molecular studies showed that NBD specifically blocked P. aeruginosa's LasR and disrupted its functional dimeric structure.
Article
Environmental Sciences
Xiling Yang, Shujun Jiang, Jing Ma, Wenshuai Li, Changjiang Zhao, Wenyan Fan
Summary: The cAMP-PKA signaling pathway is crucial for fungal sclerotial development, with the PICA gene playing an essential role. This study provides valuable insights into the molecular mechanisms regulating sclerotial development in Rhizoctonia solani.
FRESENIUS ENVIRONMENTAL BULLETIN
(2022)
Article
Cell Biology
Yoshikazu Hirate, Shino Hirahara, Ken-ichi Inoue, Hiroshi Kiyonari, Hiroshi Niwa, Hiroshi Sasaki
DEVELOPMENT GROWTH & DIFFERENTIATION
(2015)
Article
Cell Biology
Hiroshi Mamada, Takashi Sato, Mitsunori Ota, Hiroshi Sasaki
JOURNAL OF CELL SCIENCE
(2015)
Review
Cell Biology
Hiroshi Sasaki
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2015)
Review
Cell Biology
Hiroshi Sasaki
DEVELOPMENT GROWTH & DIFFERENTIATION
(2017)
Article
Cell Biology
Hidekazu Ishida, Rie Saba, Ioannis Kokkinopoulos, Masakazu Hashimoto, Osamu Yamaguchi, Sonja Nowotschin, Manabu Shiraishi, Prashant Ruchaya, Duncan Miller, Stephen Harmer, Ariel Poliandri, Shigetoyo Kogaki, Yasushi Sakata, Leo Dunkel, Andrew Tinker, Anna-Katerina Hadjantonakis, Yoshiki Sawa, Hiroshi Sasaki, Keiichi Ozono, Ken Suzuki, Kenta Yashiro
Article
Biochemistry & Molecular Biology
Kanako Saito, Ryotaro Kawasoe, Hiroshi Sasaki, Ayano Kawaguchi, Takaki Miyata
NEUROCHEMICAL RESEARCH
(2018)
Article
Cell Biology
Teresa Rayon, Sergio Menchero, Andres Nieto, Panagiotis Xenopoulos, Miguel Crespo, Katie Cockburn, Susana Canon, Hiroshi Sasaki, Anna-Katerina Hadjantonakis, Jose Luis de la Pompa, Janet Rossant, Miguel Manzanares
DEVELOPMENTAL CELL
(2014)
Article
Developmental Biology
Yu Imuta, Hiroshi Koyama, Dongbo Shi, Mototsugu Eiraku, Toshihiko Fujimori, Hiroshi Sasaki
MECHANISMS OF DEVELOPMENT
(2014)
Article
Multidisciplinary Sciences
Yusuke Watanabe, Kota Y. Miyasaka, Atsushi Kubo, Yasuyuki S. Kida, Osamu Nakagawa, Yoshikazu Hirate, Hiroshi Sasaki, Toshihiko Ogura
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Keiichiro Kamura, Jihoon Shin, Hiroshi Kiyonari, Takaya Abe, Go Shioi, Atsunori Fukuhara, Hiroshi Sasaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Review
Cell Biology
Masakazu Hashimoto, Hiroshi Sasaki
CURRENT OPINION IN CELL BIOLOGY
(2020)
Article
Cell Biology
Tomoaki Otsuka, Hiromi Shimojo, Hiroshi Sasaki
Summary: During the first stage of cell differentiation in mouse development, the Hippo signaling pathway regulates the differentiation of the trophectoderm and inner cell mass. The localization of Yes-associated protein 1 (YAP) in embryos is established in a position-dependent manner at the 32-cell stage. YAP localization in daughter cells is influenced by the YAP localization in mother cells, and gradually changes to the final pattern.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Cell Biology
Katsura Minegishi, Masakazu Hashimoto, Rieko Ajima, Katsuyoshi Takaoka, Kyosuke Shinohara, Yayoi Ikawa, Hiromi Nishimura, Andrew P. McMahon, Karl Willert, Yasushi Okada, Hiroshi Sasaki, Dongbo Shi, Toshihiko Fujimori, Toshihisa Ohtsuka, Yasunobu Igarashl, Terry P. Yamaguchi, Akihiko Shimono, Hidetaka Shiratori, Hiroshi Hamada
DEVELOPMENTAL CELL
(2017)
Article
Medicine, Research & Experimental
Yoshikazu Hirate, Hiroshi Sasaki