Review
Chemistry, Multidisciplinary
Shouwei Zhang, Fan Xia, Sophie Demoustier-Champagne, Alain M. Jonas
Summary: Layer-by-layer assembly is a versatile technology for constructing multifunctional nanomaterials with fine control over thickness and structure, suitable for various applications in nanochannels with different growth mechanisms. It shows potential for numerous applications in fields such as nanoreactors, drug delivery, and fluidic devices.
Review
Chemistry, Multidisciplinary
Jie Zhu, Nicole Avakyan, Albert Kakkis, Alexander M. Hoffnagle, Kenneth Han, Yiying Li, Zhiyin Zhang, Tae Su Choi, Youjeong Na, Chung-Jui Yu, F. Akif Tezcan
Summary: Proteins, as nature's primary building blocks for sophisticated molecular machines and materials, have inspired extensive efforts in the rational design of artificial protein assemblies in the last two decades. Scientists have devised creative strategies by combining tools and principles of various disciplines to control the self-assembly of complex proteins, leading to artificial protein assemblies with unprecedented structures and functions, as well as protein-based materials with unusual properties.
Article
Multidisciplinary Sciences
Jia Duan, Heng Liu, Fenghui Zhao, Qingning Yuan, Yujie Ji, Xiaoqing Cai, Xinheng He, Xinzhu Li, Junrui Li, Kai Wu, Tianyu Gao, Shengnan Zhu, Shi Lin, Ming-Wei Wang, Xi Cheng, Wanchao Yin, Yi Jiang, Dehua Yang, H. Eric Xu
Summary: Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) regulates G-protein and arrestin signalling, which can be modulated by biased ligands. However, the molecular assembly of GRKs on GPCRs and the mechanisms of GRK-mediated biased signalling are not well understood. This study presents the complex structure of neurotensin receptor 1 (NTSR1) bound to GRK2, Ga-q, and the arrestin-biased ligand SBI-553. The structure provides insights into the details of GPCR-GRK interactions and the mechanisms underlying GRK2-mediated biased signalling.
Article
Multidisciplinary Sciences
Hironori Takeda, Akihisa Tsutsumi, Tomohiro Nishizawa, Caroline Lindau, Jon Busto, Lena-Sophie Wenz, Lars Ellenrieder, Kenichiro Imai, Sebastian P. Straub, Waltraut Mossmann, Jian Qiu, Yu Yamamori, Kentaro Tomii, Junko Suzuki, Takeshi Murata, Satoshi Ogasawara, Osamu Nureki, Thomas Becker, Nikolaus Pfanner, Nils Wiedemann, Masahide Kikkawa, Toshiya Endo
Summary: The study reveals that beta-barrel proteins in the mitochondrial outer membrane are inserted by the multisubunit mitochondrial SAM complex. The structure of the SAM complex, determined using cryo-electron microscopy, shows the involvement of proteins such as Sam50, Sam35, Sam37, and Mdm10 in the process.
Article
Chemistry, Multidisciplinary
Shuwang Wu, Zhenyu Liang, Yupeng Li, Sarah Chay, Zhiyuan He, Sicong Tan, Jianjun Wang, Xinyuan Zhu, Ximin He
Summary: Transparent, photothermic, and icephobic composite surfaces are developed with high transparency, photothermal capabilities, and resistance to frosting and ice adhesion.
Article
Polymer Science
Ana Mateos-Maroto, Laura Fernandez-Pena, Irene Abelenda-Nunez, Francisco Ortega, Ramon G. Rubio, Eduardo Guzman
Summary: This review provides an updated perspective on the various applications of polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method in the biomedical field, emphasizing the significant advantages offered by the LbL method for fabricating platforms for different disease detection and treatment.
Article
Engineering, Environmental
Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu
Summary: The scalable basswood-based PDA/GO-embedded self-assembly membranes were prepared for highly selective adsorption and transport of substances. The membranes demonstrated perfect rebinding selectivity and perm-selectivity for Ars.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Houmei You, Kewei Zhang, Xiangkun Zhang, Huiping Ding, Yiwen Shen, Yongjun Feng, Jinpeng Hou, Weiliang Tia
Summary: This research describes the fabrication of multilayer ordered vermiculite-based luminescent thin films and demonstrates their potential application in optical devices. The study shows that luminescent films with high luminous properties and optical stability can be achieved by layer-by-layer assembly of CdTe quantum dots on vermiculite.
APPLIED CLAY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Paola Lanzoni-Mangutchi, Oishik Banerji, Jason Wilson, Anna Barwinska-Sendra, Joseph A. Kirk, Filipa Vaz, Shauna O'Beirne, Arnaud Basle, Kamel El Omari, Armin Wagner, Neil F. Fairweather, Gillian R. Douce, Per A. Bullough, Robert P. Fagan, Paula S. Salgado
Summary: S-layers are two-dimensional protein arrays that cover the surface of bacteria and archaea, playing important roles in cell physiology. In this study, the crystal structure of the main S-layer protein SIpA from the bacterial pathogen Clostridioides difficile was determined, and the organization and assembly mechanism of the S-layer was studied using electron microscopy. The compact and tightly-packed array of triangular prisms in the crystal lattice mimics the assembly of the S-layer in the cell, and the flexible ridges on the surface of the array were found to be dispensable for overall structure and assembly.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Lars Wagberg, Johan Erlandsson
Summary: This review discusses the current knowledge about the formation of layer-by-layer (LbL) self-assemblies using combinations of nanocelluloses (NCs) and polyelectrolytes. It focuses on the fundamentals behind LbL formation with a special emphasis on NCs, as well as the limiting factors for the formation of LbLs of only NCs and the combination of NCs and polyelectrolytes/nanoparticles. The review also highlights the ability of NCs and polyelectrolytes to form dense films with excellent mechanical properties and tailored optical properties, and explores the potential uses of LbLs containing NCs.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Wenjie Li, Yuncong Jiang, Hang Liu, Chen Wang, Xin Zhou, Siyi Jiang, Yuwen Mu, Linyan Wang, Xiaodong He, Mingwei Li, Fei He
Summary: This paper presents a new method for preparing ultrastrong mullite fiber aerogels (MFAs) with quasi-ordered structures. By optimizing the fiber orientation and constructing fibrous layers and fiber bridges, the fabricated MFAs exhibit high compression fatigue resistance, temperature-invariant compression resilience, and low thermal conductivity, making them attractive for efficient thermal insulation in extreme environments.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Chen Wang, Myoung Jun Park, Hanwei Yu, Hideto Matsuyama, Enrico Drioli, Ho Kyong Shon
Summary: This review comprehensively investigates the latest research achievements of nanocomposite membranes prepared by layer-by-layer (LBL) assembly. Different fabrication methods are introduced, and the applications and challenges of nanocomposite membranes in various separation areas are summarized.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Nada Farag, Gianfranco Ercolani, Erica Del Grosso, Francesco Ricci
Summary: In this study, we demonstrate the use of DNA repair enzymes to control the assembly of DNA-based structures. By designing responsive nucleic acid modules and utilizing specific enzyme repair activity, we were able to achieve the self-assembly of DNA tiles into tubular structures. This approach is programmable, specific, and orthogonal, allowing for accurate prediction of tile distribution. Additionally, we show that BER-enzyme inhibitors can be used to control DNA-tile assembly in a specific and concentration-dependent manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
S. Farzad Ahmadi, Viverjita Umashankar, Zaara Dean, Brian Chang, Sunghwan Jung, Jonathan B. Boreyko
Summary: The study shows that air pockets within stacked layers of porous superhydrophobic feathers can withstand higher water pressure due to the redundant pathway for water impalement, which increases the pressure on the enclosed air pockets. In addition, filling the feathers with oil to suppress the layer effect confirms the potential application in reducing drag and fouling of marine structures or enhancing desalination membranes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Takaya Ikami, Yuki Watanabe, Hiroki Ogawa, Mikihito Takenaka, Norifumi L. Yamada, Makoto Ouchi, Hiroyuki Aoki, Takaya Terashima
Summary: By controlling the composition of the copolymers with octadecyl groups and hydroxyethyl groups in solution, ordered lamellar structures can be formed in the solid state, while spin-coating the polymer solutions onto silicon substrates allows the copolymers to autonomously form multilayered lamellar thin films.
Article
Chemistry, Physical
Takashi Toyao, Md Nurnobi Rashed, Yoshitsugu Morita, Takashi Kamachi, S. M. A. Hakim Siddiki, Md A. Ali, A. S. Touchy, Kenichi Kon, Zen Maeno, Kazunari Yoshizawa, Ken-ichi Shimizu
Article
Biochemistry & Molecular Biology
Yoshitsugu Morita, Keisuke Igarashi, Ryosuke Funaki, Teruyuki Komatsu
Article
Chemistry, Inorganic & Nuclear
Ning Xu, Toshikazu Ono, Yoshitsugu Morita, Teruyuki Komatsu, Yoshio Hisaeda
Summary: The first boron complexes of porphycenes, structural isomers of porphyrin, have been successfully synthesized using a microwave-assisted method, resulting in two different coordination structures. Monoboron porphycene favors coordination on the dipyrroethene site, while the regioisomer of diboron porphycene with cisoid stereochemistry is more stable. Protonation results in red shift in both absorption and emission spectra for monoboron porphycene, with a reversible trigger using acids and bases.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Kazuya Kanemoto, Koudai Furuhashi, Yoshitsugu Morita, Teruyuki Komatsu, Shin-ichi Fukuzawa
Summary: A new method involving trifluoroacetic acid-mediated desulfurilative sulfonylthiolation of arenes using SS-morpholino dithiosulfonate was described. The reaction proceeds through electrophilic aromatic substitution followed by sulfur extrusion, enabling expedited access to diverse multifunctionalized sulfides.
Article
Chemistry, Multidisciplinary
Yuto Enomoto, Motofusa Akiyama, Yoshitsugu Morita, Teruyuki Komatsu
Summary: A unique structure of Doxorubicin-loaded liposomes (DoxLs) spontaneously absorbed into nanotubes comprising polyelectrolytes and gold nanoparticles was described, with efficient drug release induced by heating stimuli. The study also elucidated the antitumor activity of this structure on cancer cells.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Taiga Yamada, Yoshitsugu Morita, Ryoya Takada, Mizuki Funamoto, Wataru Okamoto, Mitsutomo Kohno, Teruyuki Komatsu
Summary: Myoglobin combined with human serum albumin (Mb-HSA) can be produced using yeast Pichia pastoris as a host strain, with secretion into the culture medium. The Mb-HSA fusion protein possesses identical O-2 binding affinity to that of naked Mb. The Mb unit is reconstituted with a zinc(II) protoporphyrin IX, yielding (zinc substituted Mb)-HSA, ZnMb-HSA. The photophysical property and singlet O-2 generation ability of ZnMb-HSA are equivalent to those of ZnMb. In vitro cell experiments revealed that ZnMb-HSA acts as a superior photosensitizer for photodynamic cancer therapy. It is noteworthy that ZnMb-HSA shows long circulation lifetime in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Mizuki Umebara, Natsuho Sugai, Kohei Murayama, Tomonao Sugawara, Yushi Akashi, Yoshitsugu Morita, Ryo Kato, Teruyuki Komatsu
Summary: This report details the synthesis of catalase-driven protein microtube motors with diverse exterior surfaces, showcasing their capabilities in capturing bacteria, enhancing reactions through self-stirring, and controlling velocity with light irradiation. The results demonstrate that these motors act as ultra-small moving biotools with the ability to perform various functions.
MATERIALS ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Yoshitsugu Morita, Ryoya Takada, Asuka Saito, Teruyuki Komatsu
Summary: Haemoglobin-albumin trimers were synthesized as an artificial O2 carrier using five distinct Hb variants with genetically and chemically tuned structures. These trimers exhibit moderately low O2 affinity and high cooperativity, resulting in a 1.8-fold higher O2 transport efficiency compared to human RBCs.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yoshitsugu Morita, Asuka Saito, Jun Yamaguchi, Teruyuki Komatsu
RSC CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Ryo Adachi, Shun Suzuki, Tatsuya Mitsuda, Yoshitsugu Morita, Teruyuki Komatsu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Koki Torita, Ryosuke Haraguchi, Yoshitsugu Morita, Satoshi Kemmochi, Teruyuki Komatsu, Shin-ichi Fukuzawa
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Inorganic & Nuclear
Luxia Cui, Toshikazu Ono, Yoshitsugu Morita, Yoshio Hisaeda
DALTON TRANSACTIONS
(2020)
Article
Materials Science, Biomaterials
Ryosuke Funaki, Wataru Okamoto, Chihiro Endo, Yoshitsugu Morita, Kiyohito Kihira, Teruyuki Komatsu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Nanoscience & Nanotechnology
Yoko Nakai, Natsuho Sugai, Hinako Kusano, Yoshitsugu Morita, Teruyuki Komatsu
ACS APPLIED NANO MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Ryosuke Funaki, Tomonori Kashima, Wataru Okamoto, Sho Sakata, Yoshitsugu Morita, Masayo Sakata, Teruyuki Komatsu
