The role of different SIRT1-mediated signaling pathways in toxic injury

SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride

(2019) Xiaolong Gu et al.   TOXICOLOGY IN VITRO

Transcription Factor NF-κB: An Update on Intervention Strategies

(2016) Arvind Panday et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride

(2016) Xiaolong Gu et al.   Oncotarget

Disruption of Sirtuin 1–Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling

(2015) Maiko Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 Protects Against Oxidative Stress-Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation

(2015) Yu-Qiang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

P53 and Sirt1: Routes of metabolism and genome stability

(2014) Stefania Gonfloni et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-κB pathway

(2014) Rong Guo et al.   Diabetes & Vascular Disease Research

Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

(2014) Yi Cheng et al.   JOURNAL OF NEUROIMMUNOLOGY

N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes

(2014) Jicang Wang et al.   Journal of Veterinary Science

Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation

(2014) Young-Sool Hah et al.   PLoS One

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

(2013) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins

(2013) Soo-Jin Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways

(2013) Yong-guang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription

(2013) Claire Curtil et al.   FASEB JOURNAL

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

(2013) Jae-Woong Hwang et al.   FASEB JOURNAL

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats

(2013) Yong-Ru Chen et al.   MOLECULAR BIOLOGY REPORTS

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex interplay between PGC-1 co-activators and mTORC1 regulates hematopoietic recovery following 5-fluorouracil treatment

(2013) Sunanda Basu   Stem Cell Research

Multiple anti-inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B-induced lung injury

(2012) Sadiye Amcaoglu Rieder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Finding a Target for Resveratrol

(2012) Ruth I. Tennen et al.   CELL

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Mammalian Sirt1: insights on its biological functions

(2011) Shahedur Rahman et al.   Cell Communication and Signaling

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights

(2011) Jung-Mi Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signalling

(2011) Aleck W.E. Jones et al.   MITOCHONDRION

Activation of FOXO3a Is Sufficient to Reverse Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor Chemoresistance in Human Cancer

(2010) Jer-Yen Yang et al.   CANCER RESEARCH

Structural studies of NF-κB signaling

(2010) Chao Zheng et al.   CELL RESEARCH

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

(2010) Albert Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer

(2009) Elisabeth R. Garwood et al.   BREAST CANCER RESEARCH AND TREATMENT

Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Δ12,14-prostaglandin J2 requires Nrf2

(2009) Simona Bancos et al.   CELLULAR IMMUNOLOGY

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Cadmium and mitochondria

(2009) Giuseppe Cannino et al.   MITOCHONDRION

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

VPA-related axial skeletal defects and apoptosis: A proposed event cascade☆

(2009) Francesca Di Renzo et al.   REPRODUCTIVE TOXICOLOGY

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

(2008) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE