WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

(2019) Woo-Jeong Jeong et al.   Nature Communications

β‐Catenin‐RAS interaction serves as a molecular switch for RAS degradation via GSK3β

(2018) Sang‐Kyu Lee et al.   EMBO REPORTS

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

(2016) Shih-Ting Cha et al.   NATURE CELL BIOLOGY

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

(2016) Pu-Hyeon Cha et al.   Nature Chemical Biology

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

(2016) Yong-Hee Cho et al.   Oncotarget

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer

(2015) Melissa R. Junttila et al.   Science Translational Medicine

Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1

(2015) Yu Zhong et al.   TOXICOLOGIC PATHOLOGY

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/β-Catenin Signaling

(2014) Byoung-San Moon et al.   JNCI-Journal of the National Cancer Institute

KRAS and Cancer Stem Cells in APC-Mutant Colorectal Cancer

(2014) E. R. Fearon et al.   JNCI-Journal of the National Cancer Institute

Prognostic Value of LGR5 in Colorectal Cancer: A Meta-Analysis

(2014) Qing Chen et al.   PLoS One

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

(2013) Hugo J. Snippert et al.   EMBO REPORTS

Targeting cancer stem cells to suppress acquired chemotherapy resistance

(2013) S J Vidal et al.   ONCOGENE

Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis

(2012) W.-J. Jeong et al.   Science Signaling

Not So Lonely at the Top for Cancer Stem Cells

(2011) Ann Zeuner et al.   Cell Stem Cell

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool

(2011) Ying Feng et al.   GASTROENTEROLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE