Article
Cell Biology
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
Summary: The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a critical role in shaping the peptide-MHC I repertoire and maintaining immune surveillance. Murine cytomegalovirus (MCMV) modulates ERAAP during infection, leading to Qa-1b-restricted QFL T cell proliferation, which reduces viral load and highlights potential targets for anti-viral therapies.
Article
Biochemistry & Molecular Biology
Na Zhao, Guojian Wang, Shuang Long, Dengqun Liu, Jining Gao, Yang Xu, Cheng Wang, Aiping Wang, Fengchao Wang, Yuhui Hao, Xinze Ran, Junping Wang, Yongping Su, Tao Wang
Summary: The study identifies an endogenous pattern involving Spink7 in the immune compartment as a key player in controlling chemokines/cytokines production, contributing to the resolution of inflammation in colitis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Oncology
Emilie Barsac, Carolina de Amat Herbozo, Loic Gonzalez, Thomas Baranek, Thierry Mallevaey, Christophe Paget
Summary: This review highlights the emerging role of unconventional T cells in tumor immunity, focusing on their protumoral functions and the factors in the tumor microenvironment shaping and controlling these deleterious properties. Unconventional T cells like gamma delta T cells, natural killer T (NKT) cells, and mucosal-associated invariant T (MAIT) cells span the innate-adaptive continuum and possess unique abilities to rapidly react to nonpeptide antigens. The potential therapeutic implications of targeting these unconventional T cell subsets in solid cancers are discussed, along with the need for further feasibility studies in this area.
Article
Cell Biology
Yue Liu, Guangna Liu, Jiasheng Wang, Zhe-Yu Zheng, Lemei Jia, Wei Rui, Daosheng Huang, Zhi-Xiao Zhou, Liqun Zhou, Xin Wu, Song Lin, Xueqiang Zhao, Xin Lin
Summary: A new double-chain chimeric receptor STAR was constructed to mediate strong and sensitive TCR-like signaling upon antigen stimulation, showing better antigen sensitivity and less risk of dysfunction compared to traditional CAR-T cells. In multiple solid tumor models, STAR-T cells outperformed BBzCAR-T cells and showed superior antitumor effects.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Amelie Cachot, Mariia Bilous, Yen-Cheng Liu, Xiaokang Li, Margaux Saillard, Mara Cenerenti, Georg Alexander Rockinger, Tania Wyss, Philippe Guillaume, Julien Schmidt, Raphael Genolet, Giuseppe Ercolano, Maria Pia Protti, Walter Reith, Kalliopi Ioannidou, Laurence de Leval, Joseph A. Trapani, George Coukos, Alexandre Harari, Daniel E. Speiser, Alexander Mathis, David Gfeller, Hatice Altug, Pedro Romero, Camilla Jandus
Summary: CD4 T cells displaying cytotoxic phenotypes were identified in different human cancers through mining single-cell RNA-seq datasets. Ex vivo confirmation of the cytolytic tumor-specific CD4 T cells was achieved using peptide-MHCII-multimer technology. The cytotoxic activity of these cells, partially dependent on SLAMF7, was demonstrated to have delayed kinetics compared to classical cytotoxic lymphocytes, and agonistic engagement of SLAMF7 enhanced their cytotoxicity, indicating potential synergy with other cancer immunotherapies.
Article
Microbiology
Ana Montalban-Arques, Egle Katkeviciute, Philipp Busenhart, Anna Bircher, Jakob Wirbel, Georg Zeller, Yasser Morsy, Lubor Borsig, Jesus F. Glaus Garzon, Anne Mueller, Isabelle C. Arnold, Mariela Artola-Boran, Michael Krauthammer, Anna Sintsova, Nicola Zamboni, Gabriel E. Leventhal, Laura Berchtold, Tomas de Wouters, Gerhard Rogler, Katharina Baebler, Marlene Schwarzfischer, Larissa Hering, Ivan Olivares-Rivas, Kirstin Atrott, Claudia Gottier, Silvia Lang, Onur Boyman, Ralph Fritsch, Markus G. Manz, Marianne R. Spalinger, Michael Scharl
Summary: Despite the overall success of T cell checkpoint inhibitors in cancer treatment, research has found that certain commensal species of gut microbiota associated with lower tumor burden and are significantly reduced in CRC patients. Oral application of specific Clostridiales strains can prevent and even treat CRC successfully in mouse models, outperforming anti-PD-1 therapy in some cases. This indicates the potential of gut bacteria as a novel stand-alone therapy against solid tumors.
CELL HOST & MICROBE
(2021)
Article
Immunology
Anna Christina Dragon, Luca Marie Beermann, Melina Umland, Agnes Bonifacius, Chiara Malinconico, Louisa Ruhl, Patrik Kehler, Johanna Gellert, Lisa Weiss, Sarah Mayer-Hain, Katharina Zimmermann, Sebastian Riese, Felicitas Thol, Gernot Beutel, Britta Maecker-Kolhoff, Fumiichiro Yamamoto, Rainer Blasczyk, Axel Schambach, Michael Hust, Michael Hudecek, Britta Eiz-Vesper
Summary: CD176-CAR-T cells specifically recognize the widely expressed CD176 antigen on cancer cells, providing a promising approach for the treatment of various blood and solid tumors while avoiding on-target/off-tumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Stephen Iwanowycz, Soo Ngoi, Yingqi Li, Megan Hill, Christopher Koivisto, Melodie Parrish, Beichu Guo, Zihai Li, Bei Liu
Summary: DC2s, the majority of conventional DCs within most tumors, have the potential to initiate and sustain antitumor immunity, showing significant correlation with survival across multiple human cancers. Impairment of DC1s and enhancement of DC2 functionality leads to improved tumor control, highlighting the therapeutic and prognostic potential of DC2s within checkpoint blockade-resistant tumors.
Article
Oncology
Tiffany R. Emmons, Thejaswini Giridharan, Kelly L. Singel, Anm Nazmul H. Khan, Jason Ricciuti, Kaitlyn Howard, Stephanie L. Silva-Del Toro, Ivy L. Debreceni, Cathelijn E. M. Aarts, Mieke C. Brouwer, Sora Suzuki, Taco W. Kuijpers, Ilse Jongerius, Lee-Ann H. Allen, Viviana P. Ferreira, Anna Schubart, Holger Sellner, Jorg Eder, Steven M. Holland, Sanjay Ram, James A. Lederer, Kevin H. Eng, Kirsten B. Moysich, Kunle Odunsi, Michael B. Yaffe, Emese Zsiros, Brahm H. Segal
Summary: Research has shown that ascites fluid supernatants from ovarian cancer patients in the tumor microenvironment can prolong neutrophil lifespan, decrease neutrophil density, and induce nuclear hypersegmentation. Ascites fluid supernatants induce distinct neutrophil clusters and stimulate complement deposition and signaling in neutrophils, resulting in neutrophil suppressor function.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Cooper J. Sailer, Yeonsun Hong, Ankit Dahal, Allison T. Ryan, Sana Mir, Scott A. Gerber, Patrick M. Reagan, Minsoo Kim
Summary: Chimeric antigen receptor (CAR)-T cell therapy shows promise in treating hematologic cancers, but its success in solid tumors is limited due to CAR-T cell exhaustion and poor persistence. This study finds that PD-1(high) CAR-T cells perform better in multiple T cell functions compared to PD-1(low) CAR-T cells. However, adoptive transfer of PD-1(high) CAR-T cells alone is insufficient to control tumor growth, and a combination therapy with PD-1 blockade is needed for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yang Liu, Xiao Wang, Jing Li, Jian Tang, Bin Li, Yu Zhang, Ning Gu, Fang Yang
Summary: The study describes a liposome drug delivery system that targets glioblastoma multiforme (GBM) blood vessels and enhances the permeability of the brain-blood-tumor barrier (BBTB). This system successfully delivers a nitric oxide prodrug to GBM tumors, showing promise for targeted therapies against GBM and other cancers characterized by elevated S1PR expression.
ADVANCED MATERIALS
(2021)
Article
Medicine, Research & Experimental
Yizhao Chen, Zhiying Yu, Xuewen Tan, Haifeng Jiang, Zhen Xu, Yilong Fang, Dafei Han, Wenming Hong, Wei Wei, Jiajie Tu
Summary: CAR-M therapy shows potential in targeting solid tumors, but there are limitations that need further research to enhance its therapeutic efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Multidisciplinary
Ruxing Fu, Hongjun Li, Ruoxin Li, Kyle McGrath, Gianpietro Dotti, Zhen Gu
Summary: CAR T cells show promise in cancer immunotherapy, but have limited clinical success in solid tumors, leading to exploration of strategies to enhance their efficacy. Altering the tumor microenvironment is crucial, with a focus on future development directions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Alaa Alsalloum, Saleh Alrhmoun, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Julia Lopatnikova, Vasily Kurilin, Marina Volynets, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Summary: This study investigates the specific targeting potential of engineered TCR T cells against NY-ESO-1-positive tumors. The cytotoxicity and functional characteristics of these modified T cells, as well as immune transcriptome profiling and multiplex immunoassays, demonstrate their promising therapeutic potential for cancer treatment.
Article
Chemistry, Multidisciplinary
Xianjun Li, Tianchuan Zhu, Ronghao Wang, Jian Chen, Lantian Tang, Wenwen Huo, Xi Huang, Qingdong Cao
Summary: This study developed genetically programmable cellular vesicles loaded with glutamine antagonists to metabolically dismantle the immunosuppressive tumor microenvironment and enhance the efficiency of anti-mesothelin CAR-T cells in orthotopic lung cancer. The vesicles specifically targeted tumor cells and prevented the premature exhaustion of CAR-T cells by addressing the upregulation of PD-L1. Additionally, the vesicles reduced immunosuppressive cells, promoted the recruitment of inflammatory cells, and improved the infiltration and effector functions of CAR-T cells, ultimately enhancing their anti-tumor ability and long-term memory immunity.
ADVANCED MATERIALS
(2023)
Letter
Rheumatology
Maria De Santis, Antonio Voza, Victor Savevski, Salvatore Badalamenti, Maurizio Cecconi, Alberto Mantovani, Carlo Selmi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Andrea Marrari, Nicolo Gennaro, Umberto Cariboni, Vittorio Lorenzo Quagliuolo, Federico D'Orazio, Ferdinando Cananzi, Armando Santoro, Alexia Francesca Bertuzzi
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Immunology
Paolo Corradini, Chiara Agrati, Giovanni Apolone, Alberto Mantovani, Diana Giannarelli, Vincenzo Marasco, Veronica Bordoni, Alessandra Sacchi, Giulia Matusali, Carlo Salvarani, Pier Luigi Zinzani, Renato Mantegazza, Fabrizio Tagliavini, Maria Teresa Lupo-Stanghellini, Fabio Ciceri, Silvia Damian, Antonio Uccelli, Daniela Fenoglio, Nicola Silvestris, Fausto Baldanti, Giulia Piaggio, Gennaro Ciliberto, Aldo Morrone, Franco Locatelli, Valentina Sinno, Maria Rescigno, Massimo Costantini
Summary: This study investigated the immune response to the SARS-CoV-2 vaccine in patients with tumors and immune disorders. The results showed that immunosuppressive treatment was a risk factor for a low humoral response, while the booster dose improved both humoral and T-cell responses.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Davit Pipoyan, Seda Stepanyan, Meline Beglaryan, Alberto Mantovani
Summary: This study aimed to assess the dietary exposure of the adult population in Yerevan, Armenia to nickel. Based on a total diet study and analysis, fruits, vegetables, and bread were identified as the main sources of nickel intake. The estimated chronic dietary exposure was below the safety standards for both age and gender groups, suggesting low health risks. However, acute oral exposure to nickel may pose potential health concerns for sensitized individuals.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Andrea Pansa, Laura Sama, Laura Ruspi, Federico Sicoli, Ferdinando Carlo Maria Cananzi, Vittorio Quagliuolo
Summary: This article aims to present a case and a systematic review of gastric glomus tumor, highlighting its clinical, radiological, surgical, and pathological features. The study found that glomus tumor is a rare mesenchymal neoplasm with epigastric pain as the most common symptom, mostly located in the gastric antrum, and wedge resection is the preferred treatment.
DIGESTIVE DISEASES
(2023)
Review
Medicine, General & Internal
Alberto Mantovani, Cecilia Garlanda
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Nina Cortese, Roberta Carriero, Marialuisa Barbagallo, Anna Rita Putignano, Guido Costa, Fabio Giavazzi, Fabio Grizzi, Fabio Pasqualini, Clelia Peano, Gianluca Basso, Sergio Marchini, Federico Simone Colombo, Cristiana Soldani, Barbara Franceschini, Luca Di Tommaso, Luigi Terracciano, Matteo Donadon, Guido Torzilli, Paolo Kunderfranco, Alberto Mantovani, Federica Marchesi
Summary: Two M4 markers associated with opposite clinical relevance were identified through single-cell analysis, indicating the importance of improved classification and prognostic classifiers for patients with colorectal liver metastasis.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Chemistry, Physical
Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Thambusamy Stalin, Naushad Ahmad, Suliman Yousef Alomar, Yong Rok Lee
Summary: This study aims to synthesize and characterize the inclusion complex of β-cyclodextrin (B-CD) with tenofovir (TFR) and investigate its interaction with the SARS-CoV-2 (MPro) protein. The prepared B-CD:TFR inclusion complex was characterized using various techniques, confirming its formation. The results showed that the B-CD:TFR inclusion complex has excellent solubility, stability, and antiviral activity, making it a potential carrier for the treatment of viral infections.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Suliman Yousef Alomar
Summary: Multiple spectroscopic and computational methods were used to investigate the binding mechanism of doxofylline with lysozyme. The formation of complex between doxofylline and lysozyme was confirmed by UV-vis spectroscopy and fluorescence quenching. Synchronous spectroscopy showed changes in the microenvironment of lysozyme upon binding. Molecular docking and MD simulations revealed the stability and binding affinity of the lysozyme-doxofylline complex. The MM-PBSA binding energy was calculated to be -30.55 kcal mol(-1).
Review
Immunology
Francesca R. Mariotti, Domenico Supino, Nadine Landolina, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) play a crucial role in immunity and inflammation, and are expressed by various cell types. The negative regulator IL1R8 dampens ILR and TLR signaling, while also functioning as a co-receptor for IL-37. IL-1R8 is highly expressed in NK cells, which are important for immune surveillance. This review provides an overview of IL-1R8's structure, expression, and function, with a focus on its role in regulating NK cell function in pathological conditions such as cancer and viral infections.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Polymer Science
Hadia Baloch, Aisha Siddiqua, Asif Nawaz, Muhammad Shahid Latif, Syeda Qurbat Zahra, Suliman Yousef Alomar, Naushad Ahmad, Tarek M. Elsayed
Summary: The aim of this study was to synthesize sulfur nanoparticles (SNPs) from Citrus limon leaves that are non-noxious, clean, reliable, and green. The synthesized SNPs were characterized for their particle size, surface charge, and functional properties. The SNPs exhibited a globule size of 55.32 +/- 2.15 nm, PDI value of 0.365 +/- 0.06, and zeta potential of -12.32 +/- 0.23 mV. Antimicrobial and antifungal studies showed that the SNPs had better activity against various strains at a minimal inhibitory concentration of 50 μg/mL. Additionally, embedding the SNPs in a nanohydrogel formulation showed promising results in wound healing studies.
Article
Surgery
Laura Sama, Ferdinando C. M. Cananzi, Fulvia Aymerito, Laura Ruspi, Vittorio Quagliuolo, Carlo Castoro
Summary: This article presents a case of minimally invasive laparoscopic resection of a gastric leiomyoma, guided by laparoscopic ultrasound. The procedure was performed successfully in a 52-year-old male patient.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Zaeema Usman, Zakia Kanwal, Asima Tayyeb, Iqra Noshair, Imran Haider, Naushad Ahmad, Suliman Yousef Alomar
Summary: The study investigated the effects of Pseudomonas aeruginosa and Fusarium oxysporum on Cirrhinus mrigala, and found significant changes in cytokine expression, hemato-biochemical parameters, and tissue histology of the infected fish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Raffaella Parente, Maria Rita Fumagalli, Alessia Di Claudio, Cindy Lorena Cardenas Rincon, Marco Erreni, Damiano Zanini, Giacomo Iapichino, Alessandro Protti, Cecilia Garlanda, Roberto Rusconi, Andrea Doni
Summary: This study highlights the importance of the extracellular matrix (ECM) and hemostasis elements in triggering Staphylococcus aureus (S. aureus) biofilm formation. Fibrinogen (FG) plays a crucial role in adhesion and formation, while fibrinolysis inhibits biofilm formation and promotes an antibody-mediated defense response.
Article
Environmental Sciences
Saif Ali Ali Sultan, Fawad Ahmed Khan, Abdul Wahab, Batool Fatima, Hira Khalid, Ali Bahader, Sher Zaman Safi, Chandrabose Selvaraj, Abid Ali, Suliman Yousef Alomar, Muhammad Imran
Summary: The use of inexpensive aluminum cookware without knowledge of its potential health risks is a growing concern. Leaching of toxic metals into food from cookware poses a serious health risk to individuals.
