Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Shaily Tyagi, Anshuman Shah, Kesiraju Karthik, Maniraj Rathinam, Vandna Rai, Nidhee Chaudhary, Rohini Sreevathsa
Summary: Climate change has increased the incidence of pests and pathogens on plants, leading to a need for effective management strategies. Plants respond to stresses by regulating cellular mechanisms through complex signaling networks. Reactive oxygen species (ROS) play a crucial role in maintaining normal plant activities and improving stress management. This review explores the signaling and management of ROS during oxidative bursts caused by plant interactions with pathogens and herbivores. The findings highlight the molecular changes and important roles of ROS in phyto-pathogen/herbivore interactions, providing insights into tackling biotic stresses and developing stress management strategies.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiajian Cao, Chunhua Wang, Ning Hao, Toru Fujiwara, Tao Wu
Summary: In this review, we summarize the perceptions and responses of ER stress and oxidative protein folding in plants and analyze the production and signaling of ROS under ER stress in detail. This provides a theoretical basis for reducing ER stress and improving crop survival rate.
Review
Plant Sciences
John T. Hancock, David Veal
Summary: NO and other RNS are key signaling molecules in plants, interacting with ROS and H2S. This translation briefly discusses the interactions between these reactive molecules and the influence of intracellular redox on ROSN.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Plant Sciences
Bardo Castro, Matteo Citterico, Sachie Kimura, Danielle M. Stevens, Michael Wrzaczek, Gitta Coaker
Summary: Recent discoveries in ROS biology have emphasized the importance of ROS production and regulation in plant responses to abiotic and biotic stresses.
Review
Biochemistry & Molecular Biology
Andrea Huwiler, Karl-Friedrich Beck, Josef Pfeilschifter
Summary: Redox-active mediators are powerful molecules regulating cellular dynamics and gene expression. Reactive oxygen species (ROS), and gasotransmitters such as NO, CO, and H2S, are key mediators, along with sphingolipid molecules. Cross-regulation between redox mediators and sphingolipids influences cell fate and organ function. This review highlights the effects of redox-active mediators on sphingolipid signaling, metabolism, and their impact on pathophysiological processes.
Review
Chemistry, Medicinal
Junmin Zhang, Dongzhu Duan, Zi-Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang
Summary: Regulating intracellular ROS levels may be an effective strategy for cancer prevention or treatment. This can be achieved through chemoprevention to reduce ROS production pathways, or through ROS-mediated anticancer therapy to stimulate ROS clearance, ultimately inhibiting tumor growth.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Plant Sciences
Mohd Saleem, Qazi Fariduddin, Christian Danve M. Castroverde
Summary: Reactive oxygen species (ROS) play important roles in regulating various processes in plants, but over-accumulation can lead to oxidative stress, emphasizing the importance of maintaining redox homeostasis. Salicylic acid (SA) serves as a chief regulator in controlling ROS and antioxidant defense system signaling, yet the underlying mechanisms require further exploration.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Yang Li, Xiaoyue Zhang, Zhihan Wang, Bowen Li, Huili Zhu
Summary: Cancer treatment is hindered by resistance to conventional therapeutic strategies, and redox homeostasis manipulation can effectively overcome drug resistance. Reactive oxygen species (ROS) regulate multiple signaling pathways and cancer cells upregulate their antioxidant system to cope with elevated ROS levels during therapy, resulting in therapeutic resistance. This review highlights the interplay between redox modification, signaling pathways, and therapeutic resistance, including altered drug efflux, action targets and metabolism, enhanced DNA damage repair, maintained stemness, and reshaped tumor microenvironment. A comprehensive understanding of these interrelationships can improve treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Guoqiang Zhao, Binbin Wu, Xiaoshan Zheng, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: We have discovered an unrecognized tidal source of reactive oxygen species (ROS) and demonstrated the generation of ROS in coastal surface soil during tidal processes. The fluctuation of redox potential and dissolved oxygen concentration follows a similar pattern to the production of ROS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Engineering, Environmental
Guoqiang Zhao, Mengxi Tan, Binbin Wu, Xiaoshan Zheng, Ruoxuan Xiong, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: Tidal-induced redox oscillations can activate thermodynamically stable iron minerals into a metastable phase for enhanced ROS production.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yeon Su Choi, Kang Moo Huh, Min Suk Shim, In Suh Park, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Summary: This study investigates the release of therapeutics in the cytosol using a diselenide-based drug carrier, identifying GSH as the major trigger for diselenide cleavage and demonstrating synergistic anticancer effects when combining the carrier with an anticancer drug. The research shows that the combined use of diselenide-based drug carrier and drug has a significant inhibitory effect on tumor growth in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Madita Knieper, Andrea Viehhauser, Karl-Josef Dietz
Summary: The redox regulatory network plays a crucial role in maintaining proper levels of ROS, and the interaction between oxylipins and the redox network is essential for stress defense signaling pathways in plants.
Review
Plant Sciences
Arun Kumar, Shweta Guleria, Dipanshu Ghosh, Vivek Dogra, Sanjay Kumar
Summary: Oxygen is essential for aerobic organisms, generating ROS during electron transport reactions. Recent studies have shown ROS play a crucial role in plant growth and stress response, with extremophytes adapting to adverse environments by minimizing ROS generation. High-altitude extremophytes, especially from the Himalayas, exhibit unique mechanisms for managing ROS, which could potentially be applied to engineer stress resilience in other plants.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Hematology
Kristen J. Bubb, Rebecca H. Ritchie, Gemma A. Figtree
Article
Cardiac & Cardiovascular Systems
Thomas S. S. Hansen, Kristen J. J. Bubb, Gabriele G. G. Schiattarella, Martin Ugander, Timothy C. C. Tan, Gemma A. A. Figtree
Summary: This study evaluated the diagnostic performance of tricuspid annular plane systolic excursion (TAPSE), RV peak systolic myocardial velocity (s'), RV myocardial performance index (MPI), and RV fractional area change (FAC) in a mouse model of pulmonary hypertension. The results showed that these measures can be consistently measured in mice and are sensitive and specific indicators of pulmonary pressure and RV function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)