Article
Biophysics
Chong-Hua Zhang, Ke Cai, Peng-Ge Zhang, Zhan Wu, Ming Ma, Bo Chen
Summary: The novel cancer theragnostic nanoassembly developed has high biocompatibility, stability, and low toxicity, and can be rapidly activated by the tumor microenvironment for selective fluorescence imaging, chemotherapy, and chemoenzymatic therapy. It shows great potential in cancer diagnosis and efficient therapy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Biomedical
Weijia Xu, Junxia Wang, Liangjie Jin, Yueqiang Zhu, Xianzhu Yang
Summary: This study presents a tumor acidity-driven transformable polymeric nanoassembly for membrane-targeted photodynamic therapy, which disassembles at acidic pH to enhance penetration into tumor tissue and direct anchoring to cancer cell membrane, achieving superior tumor growth inhibition under light irradiation.
Article
Chemistry, Multidisciplinary
Yue Yan, Junlin Li, Xiaoli Yi, Chendong Liu, Zhou Zhou, Yuan Huang, Lian Li
Summary: This study developed a combination strategy to enhance chemotherapy sensitivity and suppress tumor metastasis by modulating tumor microenvironment pH. It demonstrated significant inhibition of tumor growth and reduction of metastasis in an orthotopic breast cancer mouse model.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Zi-Yi Han, Qi-Wen Chen, Zhuang-Jiong Fu, Si-Xue Cheng, Xian-Zheng Zhang
Summary: The study demonstrates that the probiotic spore-based oral drug delivery system can enhance pancreatic cancer chemotherapy through gut-pancreas axis translocation, increasing drug accumulation within tumors. The system shows significant tumor growth suppression in animal models without obvious side effects.
Article
Biochemistry & Molecular Biology
Ridong Li, Xianling Ning, Jianan He, Zhiqiang Lin, Yue Su, Runtao Li, Yuxin Yin
Summary: In this study, a novel PKM2 activator, compound 8a, was discovered from a compound library screening, leading to the synthesis of analogs such as compound 8b and 8k which showed higher PKM2 activation and anti-proliferative activities. Compound 8k demonstrated potent inhibition of cancer cell proliferation with low toxicity to normal cells, and also inhibited colony formation of MCF7 cells by blocking PKM2 signaling pathway. These findings suggest that compound 8k could be a promising candidate for further exploration in PKM2-related mechanisms and cancer therapy.
BIOORGANIC CHEMISTRY
(2021)
Article
Immunology
Venkatesh Pooladanda, Sowjanya Thatikonda, Sai Priya Muvvala, Chandraiah Godugu
Summary: Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 has led to global pandemics and is highly contagious. Inflammation, specifically cytokine storm, plays a critical role in promoting lung metastasis by creating suitable conditions for the tumor microenvironment. In this study, LPS-induced lung inflammation was found to activate BRD4, resulting in the nuclear translocation of p65 NF-Kappa B and STAT3, leading to transcriptional activation and enhanced tumor metastasis. Furthermore, LPS-induced ARDS may contribute to the promotion of the tumor microenvironment and increased lung metastasis. Collectively, BRD4 serves as a diagnostic and molecular target for inflammation-associated cancers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Materials Science, Biomaterials
Ning Wang, Chenyu Liu, Weihe Yao, Hengjun Zhou, Simiao Yu, Hailiang Chen, Weihong Qiao
Summary: The synthesized pH/ROS dual-responsive multifunctional nanoparticles TLDCAG NPs show promising potential in tumor therapy, with abilities including multi-drug release and induction of tumor cell apoptosis.
BIOMATERIALS SCIENCE
(2021)
Article
Environmental Sciences
Minjie Li, Yuan Zhong, Miao Wang
Summary: Fat1 suppresses the tumor-initiating ability of NSCLC cells by activating Hippo signaling.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Weixi Jiang, Lei Su, Meng Ao, Xun Guo, Chen Cheng, Yuanli Luo, Zhuoyan Xie, Xingyue Wang, Junrui Wang, Shuling Liu, Yang Cao, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou, Jianli Ren
Summary: This study demonstrates a significant enhancement in therapeutic efficacy against MDR cells and syngeneic tumors using a combo nanoagent equipped with triple synergistic strategies. These strategies include tumor targeting and penetrating capabilities, proton sponge effect, and scavenging endogenous glutathione, combined with photoacoustic imaging for visualization. Moreover, the nanoparticles combined with PD-1/PD-L1 blockade therapy can activate immunological responses and inhibit P-gp expression to eliminate primary and metastatic tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Neurosciences
Y. Zhang, Z. Wu, Z. Huang, Y. Liu, X. Chen, X. Zhao, H. He, Y. Deng
Summary: This study investigated whether lysosomal dysfunction in neurons can be restored by inhibiting GSK-3β to alleviate post-stroke damage. The results showed that GSK-3β inhibition can significantly mitigate neurological injury in ischemic stroke, and the alteration of lysosomal capacity affects this neuroprotection.
Article
Engineering, Biomedical
Jianquan Guo, Dongsheng Tan, Chenmei Lou, Shiying Guo, Xing Jin, Haijing Qu, Lijia Jing, Sijin Li
Summary: Nanoparticle-based chemophotothermal therapy is a promising treatment for multidrug resistant tumors. In this study, a drug nanococktail called DIR825@histone was developed for interventional nucleus-targeted CPT. It showed efficient tumor penetration, good photothermal performance, and thermal-triggered drug release. This strategy holds great promise for treating multidrug resistant tumors and can reduce skin injury by promoting the sufficient delivery of laser energy inside the tumor.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xuewen Zhang, Nianping Wu, Huili Huang, Shi Li, Shicheng Liu, Rui Zhang, Yuan Huang, Hao Lyu, Shuai Xiao, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Summary: PTTG1 is a bona fide β-catenin binding protein that positively regulates Wnt/β-catenin signaling by inhibiting the destruction complex assembly and promoting β-catenin stabilization and nuclear localization. PTTG1's subcellular distribution is regulated by its phosphorylation status. It is highly expressed in hepatocellular carcinoma (HCC) and associated with poor patient prognosis, as it promotes the proliferation and metastasis of HCC cells.
Article
Oncology
Sung Ung Moon, Jang Hyun Kim, Hyun Goo Woo
Summary: RBM24 functions as a tumor suppressor in liver cancer cells by inhibiting nuclear translocation of beta-catenin and tumor protein 63 expression, as well as suppressing sphere formation in liver cancer cells. It is hypothesized to be a potential novel therapeutic target for liver cancer treatment.
Article
Biology
C. G. Dias, L. Venkataswamy, S. Balakrishna
Summary: The study evaluated the impact of CML on NF-kappa B gene expression and TNF production, finding that patients with diabetic nephropathy and type II diabetes mellitus showed an elevated response to CML.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Hematology
Anja Schmitt, Wendan Xu, Philip Bucher, Melanie Grimm, Martina Konantz, Heike Horn, Myroslav Zapukhlyak, Philipp Berning, Marc Braendle, Mohamed-Ali Jarboui, Caroline Sch Onfeld, Karsten Boldt, Andreas Rosenwald, German Ott, Michael Grau, Pavel Klener, Petra Vockova, Claudia Lengerke, Georg Lenz, Klaus Schulze-Osthoff, Stephan Hailfinger
Summary: The study demonstrates the broad antitumor effect of dimethyl fumarate (DMF) on both subtypes of DLBCL by inducing ferroptosis, especially in GCB DLBCL. In ABC DLBCL cells, DMF treatment efficiently inhibits the activity of the IKK complex and Janus kinases. Additionally, the combination of BCL-2-specific BH3 mimetic ABT-199 and an inhibitor of ferroptosis suppressor protein 1 synergize with DMF in inducing cell death in DLBCL.
Article
Chemistry, Multidisciplinary
Jimin Guo, Shahrouz Amini, Qi Lei, Yuan Ping, Jacob Ongudi Agola, Lu Wang, Liang Zhou, Jiangfan Cao, Stefan Franco, Achraf Noureddine, Ali Miserez, Wei Zhu, C. Jeffrey Brinker
Summary: Freezing cells in amorphous silica is an effective method for long-term preservation of mammalian cell proteomic structure and function at room temperature, avoiding issues related to cryopreservation.
Article
Chemistry, Multidisciplinary
Xinying Yu, Tongyi Shang, Guodong Zheng, Hailong Yang, Yuwei Li, Yanjun Cai, Guoxi Xie, Bin Yang
Summary: This study presents a rational design of iron-based nanoparticles for anti-cancer ferroustherapy. The synthesized nanomedicines effectively induce cancer cell ferroptosis through accelerated Fenton reaction and utilize photothermal effect for mild hyperthermia-assisted ferroustherapy. The nanomedicines show promising anti-cancer therapeutic efficacy by inducing ROS production and inhibiting GPX4 expression, and also possess photoacoustic imaging ability.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Qi Lei, Dengfeng He, Liangping Ding, Fanhui Kong, Peiying He, Junda Huang, Jimin Guo, C. Jeffrey Brinker, Gaoxing Luo, Wei Zhu, Yunlong Yu
Summary: In this study, a functional microneedle based on hyaluronic acid was developed for concurrent tumor photothermal therapy and skin tissue regeneration to address the problem of delayed wound healing after skin tumor resection. Natural melanin nanoparticles derived from cuttlefish ink were used to scavenge ROS and implement photothermal therapy, and these nanoparticles were encapsulated within an amorphous silica shell to stimulate skin tissue regeneration. The functional microneedle exhibited high biocompatibility and feasibility, making it a promising supplementary therapy for skin tumor resection.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ning Guo, Yu Xia, Yuxi Duan, Quanxin Wu, Le Xiao, Yaxin Shi, Bin Yang, Yun Liu
Summary: Cu2-xS nanostructures have been extensively explored as promising agents for chemodynamic therapy (CDT) and photothermal therapy (PTT) due to their efficient Cu(I)-initiated Fenton-like catalytic activity and photothermal conversion property. However, the supply of Cu(I) in the long-term is still limited, and the inherent photothermal conversion efficiency is relatively low. In this study, a self-enhanced synergistic PTT/CDT nanoplatform (Cu1.94S@MPN) was developed by coating Cu1.94S nanoparticles with Fe(III)/tannic acid-based metal-polyphenol networks (MPN). When exposed to the acidic bacterial infection microenvironment, Cu1.94S@MPN can be decomposed to release Cu(II), Fe(III) ions, and tannic acid, enabling Cu(I)/Fe(II)-rich CDT through accelerated Fenton/Fenton-like reactions. Additionally, Cu1.94S@MPN exhibits excellent photothermal antibacterial and photothermal-enhanced CDT properties, making it a potential candidate for future anti-infective therapy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yan Sheng, Zena Huang, Tenghua Zhang, Feiyang Qian, Yuqing Zhu, Zaizai Dong, Qingyang Zhang, Qi Lei, Fanhui Kong, Yuqiong Wang, Maddie Walden, Stefan Wuttke, Lingqian Chang, Wei Zhu, Jiaming Hu
Summary: A cellular-nanoporation and exosome assessment device is developed for efficient transfection and potency testing of therapeutic agents, providing a novel quantitative platform for cell electroporation and in situ RNA expression analysis using nanochannels and exosomes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Fuan Deng, Mengyi Yan, Yibin Liu, Ruixin Wang, Haiqing He, Ali Chen, Jiajia Wang, Lin Xu, Bin Yang, Hong Cheng, Shiying Li
Summary: In this study, a metal-coordinated mitochondria proto-nophore uncoupler was developed to induce local hypoxia and enhance bioreductive therapy. In vivo experiments demonstrated that this nanomedicine could regulate tumor hypoxia microenvironment and effectively inhibit tumor growth.
Article
Materials Science, Multidisciplinary
Fan Yang, Chenggang Song, Ruixuan Ji, Xiaoyi Song, Bin Yang, Yin Lv, Zhong Wei
Summary: In this study, an amphiphilic copolymer micelle was designed and synthesized, which can form stable micelles in water and effectively load the anticancer drug. The micelle exhibited stimuli-responsive characteristics and showed promising potential for cancer treatment by enhancing antioxidant capacity and synergistic effects on cancer cells.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Peiying He, Qi Lei, Bin Yang, Tongyi Shang, Jianjun Shi, Qing Ouyang, Wei Wang, Liecong Xue, Fanhui Kong, Zeyu Li, Junda Huang, Lihan Liu, Jimin Guo, C. Jeffrey Brinker, Kaisheng Liu, Wei Zhu
Summary: The microenvironment of triple-negative breast cancer (TNBC) reduces the delivery and penetration of therapeutic agents, making it difficult to eliminate cancer cells completely. In this study, a photothermal nanocluster was constructed using a size-shrinkage and ligand modification strategy, allowing for deep penetration and efficient eradication of TNBC cells.
Article
Chemistry, Multidisciplinary
Qi Lei, Yaqian Sun, Junda Huang, Wei Liu, Xiaolong Zhan, Wenxiang Yin, Sishi Guo, Anna Sinelshchikova, C. Jeffrey Brinker, Zhiyuan He, Jimin Guo, Stefan Wuttke, Wei Zhu
Summary: In order to improve the cryopreservation efficiency of red blood cells (RBC) by metal-organic frameworks (MOFs), a dimensional reduction approach has been proposed. This approach involves reducing 3D MOF nanoparticles to 2D ultra-thin metal-organic layers (MOLs). The 2D MOLs have a higher surface-to-volume ratio, which enhances interactions with the interfacial hydrogen-bonded water network and increases utilization of inner ordered structures. Thin-layered Hf-MOLs show better ice recrystallization inhibition activity (IRI) and cell recovery efficiency compared to their 3D counterparts, validating the dimensional reduction strategy for improved cryoprotectant behaviors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Yueying Xu, Yanjun Cai, Yu Xia, Quanxin Wu, Mingen Li, Ning Guo, Yingfeng Tu, Bin Yang, Yun Liu
Summary: In this study, a nano-sized photothermal agent (BSA@MPN) was developed by self-assembling Fe3+ and epigallocatechin-3-gallate (EGCG) using BSA as a nanoreactor and colloidal stabilizer. The nanoagent displayed good photothermal and ROS scavenging capabilities, as well as excellent antibacterial and anti-inflammatory effects both in vitro and in vivo. These findings suggest that this nanoagent has great potential for combined antibacterial and anti-inflammatory treatments in future clinical applications.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Fengbing He, Wenzhong Hou, Yintao Lan, Weijian Gao, Mengyu Zhou, Jinghang Li, Shutong Liu, Bin Yang, Jian Zhang
Summary: This study demonstrates the use of photoacoustic imaging and nanomaterials for detecting and diagnosing carotid artery thrombosis. The results show that the nanomaterials have excellent photoacoustic imaging capabilities in the wavelength range of 700 nm to 900 nm.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Zhijian Mai, Nengjie Cao, Erzhuo Cheng, Zhiwen Zeng, Yancong Feng, Yao Wang, Paddy J. French, Yi-Kuen Lee, Haihong Yang, Bin Yang, Hao Li, Guofu Zhou
Summary: In this study, a multifunctional self-assembled nanobomb was designed and developed, which can be used for tumor imaging and cancer therapy. The nanobomb releases a fluorescence probe and an anticancer drug simultaneously upon acidolysis, achieving high-efficiency effects.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Qi Lei, Jimin Guo, Esmeralda Arreguin-Martinez, Jianjun Shi, C. Jeffrey Brinker, Wei Zhu
Summary: By utilizing the polyhedral effects/characteristics of metal-organic frameworks (MOFs), a versatile approach to construct MOF-organosilica hybrid branched nanocomposites with MOF cores, SiO2 shells, and periodic mesoporous organosilica (PMO) branches is presented. The morphology, structure, and functions of these hybrid nanocomposites can be easily modulated by varying particle size, shape, or crystalline structures of the MOF cores. These branched multicompartment porous nanoparticles exhibit different behaviors in different cells, showing great potential as a vehicle for immunotherapy.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jimin Guo, Yunlong Yu, Wei Zhu, Rita E. Serda, Stefan Franco, Lu Wang, Qi Lei, Jacob Ongudi Agola, Achraf Noureddine, Evelyn Ploetz, Stefan Wuttke, C. Jeffrey Brinker
Summary: Armored red blood cells are a new type of hybrid biomaterials with native red blood cells assembled within and protected by a functional exoskeleton of interconnected MOF nanoparticles. The formation of exoskeletons is rapid and based on metal-phenolic coordination and hydrogen-bonding interactions. Armored RBCs retain the original properties of RBCs and demonstrate enhanced resistance against external stressors, offering potential applications in blood nitric oxide sensing or multimodal imaging.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
