The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity

The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43

(2018) Jian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy

(2017) Qiong Lin et al.   JOURNAL OF CELL SCIENCE

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1

(2016) Shouheng Jin et al.   EMBO JOURNAL

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease

(2016) Zoi Alexopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy

(2016) Robert J. Heath et al.   Cell Reports

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

(2016) Pingping Song et al.   Protein & Cell

Recurrent gain-of-function USP8 mutations in Cushing's disease

(2015) Zeng-Yi Ma et al.   CELL RESEARCH

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

SQSTM1splice site mutation in distal myopathy with rimmed vacuoles

(2015) Robert C. Bucelli et al.   NEUROLOGY

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

(2014) Zhengzhao Liu et al.   CANCER CELL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

SQSTM1 mutations – Bridging Paget disease of bone and ALS/FTLD

(2014) Sarah L. Rea et al.   EXPERIMENTAL CELL RESEARCH

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Internalized gap junctions are degraded by autophagy

(2012) John T. Fong et al.   Autophagy

Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells

(2012) Cuihong Zhou et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Cellular functions of the DUBs

(2012) M. J. Clague et al.   JOURNAL OF CELL SCIENCE

p62: a versatile multitasker takes on cancer

(2012) Jorge Moscat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How do ESCRT proteins control autophagy?

(2009) T. E. Rusten et al.   JOURNAL OF CELL SCIENCE

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL