Article
Cell & Tissue Engineering
Luz Correa-Araujo, Leonardo Prieto-Abello, Adriana Lara-Bertrand, Martha Medina-Solano, Linda Guerrero, Bernardo Camacho, Ingrid Silva-Cote
Summary: This study investigated the ability of human Wharton's jelly mesenchymal stromal cells (hWJ-MSCs) grown on human acellular dermal matrix (hADM) scaffolds and exposed to a proinflammatory environment to produce growth factors involved in skin injury repair and promote wound healing. The results showed that the hADM scaffold maintained or enhanced the production of these bioactive molecules by hWJ-MSCs and promoted the differentiation of hWJ-MSCs toward epithelial lineage. In vivo experiments demonstrated the potential of hADM and hADM/hWJ-MSCs constructs to repair skin wounds and improve the appearance of the repaired tissue.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hanna Lewandowska, Andrzej Eljaszewicz, Izabela Poplawska, Marlena Tynecka, Alicja Walewska, Kamil Grubczak, Jordan Holl, Hady Razak Hady, Slawomir Lech Czaban, Joanna Reszec, Grazyna Przybytniak, Wojciech Gluszewski, Jaroslaw Sadlo, Malgorzata Dabrowska-Gralak, Cezary Kowalewski, Piotr Fiedor, Tomasz Oldak, Artur Kaminski, Zbigniew Zimek, Marcin Moniuszko
Summary: Gamma rays and electrons with kinetic energy up to 10 MeV are commonly used for sterilizing biomaterials. However, the effects of irradiation on human acellular dermal matrices (hADMs) are still not fully understood. Research showed that radiation sterilization did not alter the architecture and three-dimensional structure of hADM, but significantly affected collagen fiber degradation and induced free radical production in a dose-dependent manner. Despite these influences, the therapeutic potential of the new transplants remained unaffected. A radiation sterilization dose of 35kGy can ensure high sterility of the dressing while maintaining its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Nemzow, Lionel S. Zuckier
Summary: A 47-year-old woman with invasive lobular carcinoma underwent prophylactic double mastectomy, revealing incidental follicular lymphoma. Reconstruction involved silicone implants and acellular dermal matrix (ADM). Post-surgery PET/CT showed moderate FDG uptake at the location of ADM slings, indicating cellular incorporation into the matrix, which resolved at the 3-month follow-up. This uptake should not be mistaken for tumor recurrence or infection.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yixin Wang, Fei Lu, Enling Hu, Kun Yu, Jiwei Li, Rong Bao, Fangyin Dai, Guangqian Lan, Ruiqi Xie
Summary: The study developed a transparent, porous, and elastic PADM by using a CaCl2-ethanol-H2O solution combined with an additional enzyme treatment. Changes in fiber organization and secondary structural changes in collagen were observed after treatment. The biocompatible PADM significantly expedited wound repair in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Kangning Lv, Lei Wang, Xiaoli He, Wenjun Li, Lei Han, Song Qin
Summary: TADM is an extracellular matrix material that mimics the cell growth environment, promoting substantial acute wound healing. Primarily composed of type I collagen, it possesses excellent physical and chemical properties, biological activity, and cell adhesion, playing a crucial role in tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Meishu Zhu, Meihui Zhu, Xiaoling Wu, Meiquan Xu, Kunwu Fan, Jinming Wang, Liyong Zhang, Meifang Yin, Jun Wu, Zhixiang Zhu, Guang Yang
Summary: The study found that adding PADM can reduce fat liquefaction and increase fat survival rate by increasing macrophage infiltration, extracellular matrix regeneration, and revascularization.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Dermatology
Feng Shang, Qiang Hou
Summary: The study aimed to observe the effect of allogeneic ADM combined with autologous razor-thin graft on patients with extensive burns and deep hand burns. Results showed significant improvements in hand appearance, wound healing, hand function, and quality of life at 6 months post operation, with the study group showing better outcomes compared to the control group.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Surgery
Malke Asaad, Sahil K. Kapur, Donald P. Baumann, Jun Liu, Charles E. Butler
Summary: In this study, we investigated the long-term outcomes of ventral hernia repair using biologic mesh. We found that biologic mesh provides durable results with relatively low rates of hernia recurrence. There were no differences in recurrence rates and surgical site occurrences between different types of mesh.
Article
Orthopedics
Evan S. Lederman, Julie B. McLean, Kurt T. Bormann, Dan Guttmann, Kenneth D. Ortega, John W. Miles, Robert U. Hartzler, Amy L. Dorfman, Davorka Softic, Xiaofei Qin
Summary: This study analyzed histologic results from 8 patients who underwent reoperations after receiving SCR using ADMs, and found evidence of active recellularization, revascularization, and remodeling of the grafts. The level of graft remodeling correlated with implant duration, suggesting successful biologic reconstruction of the superior shoulder capsule with ADMs.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Cell & Tissue Engineering
David Dolivo, Ping Xie, Chun Hou, Yingxing Li, Abigail Phipps, Thomas Mustoe, Seok Hong, Robert Galiano
Summary: This study investigated the effects of HR-ADM application on wound closure using a diabetic murine model. The results showed that HR-ADM promoted rapid wound closure and minimized granulation tissue formation. HR-ADM also facilitated cellular infiltration, neovascularization, and collagen remodeling in the wounds.
Article
Nanoscience & Nanotechnology
Katarzyna Fidecka, Nicola Rotiroti, Jessica Giacoboni, Fernando Camara, Matthieu Refregiers, Riccardo Vago, Emanuela Licandro, Frederic Jamme
Summary: This study reports the characterization of nonfluorescent halloysite nanotubes (HNTs) using multiphoton microscopy and reveals the discovery of the SH signal generated by HNTs at the nanoscale level. The study sheds light on the understanding of the signal's generation from the nanoparticle's aluminosilicate skeleton and suggests potential technological applications of HNTs in various domains.
ACS APPLIED NANO MATERIALS
(2021)
Review
Surgery
Giorgio Berna, Alessia De Grazia, Elisa Antoniazzi, Marco Romeo, Francesco Dell'Antonia, Stefano Lovero, Paolo Marchica, Christian Rizzetto, Paolo Burelli
Summary: Implant-based breast reconstruction using highly biocompatible materials like ADMs and the new generation 3D ADM BRAXON (R) Fast can achieve enhanced aesthetic and functional results, reduce infection risks, and provide optimal safety profile.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, Research & Experimental
Fuhuan Chen, Jiake Chai, Jingyu Zhao, Jiang Wu, Baoguo Chen
Summary: This study investigated the impact of exogenous hyaluronic acid on acellular dermal matrix paired with thin skin autograft. The results showed that the combination of hyaluronic acid and thin skin autograft had better biomechanical qualities and therapeutic effects compared to acellular dermal matrix alone, approaching the reconstructive result of self-thick skin autograft in all indexes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nusaibah Sallehuddin, Nur Izzah Md Fadilah, Ng Min Hwei, Adzim Poh Yuen Wen, Salma Mohamad Yusop, Nor Fadilah Rajab, Yosuke Hiraoka, Yasuhiko Tabata, Mh Busra Fauzi
Summary: Full-thickness skin wounds are a significant burden, and there is a need for safe and effective acellular skin substitutes that can restore intact physiological skin rapidly. This study successfully developed collagen-gelatin-elastin (CollaGee) biomaterials cross-linked with genipin (GNP) flavonoids to enhance mechanical properties and degradation rate. The GNP-cross-linked CollaGee showed improved physicochemical properties and mechanical properties compared to the non-cross-linked CollaGee group. Both cross-linked and non-cross-linked CollaGee demonstrated good cellular compatibility and sustained cell viability, suggesting the potential of GNP-cross-linked CollaGee for the rapid treatment of full-thickness skin loss.
Article
Medicine, General & Internal
Jose da Conceicao Carvalho, Fabiana Zanata, Antonio Carlos Aloise, Lydia Masako Ferreira
Summary: The study showed that the use of acellular dermal matrix in skin wound healing in rabbits increased the thickness of the dermal and epidermal layers, as well as the amount of type I and III collagen. There was no significant difference in the healing rate between the matrix group and control group.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
