Review
Cell Biology
Jun Guo, Jue Wu, Qinyuan He, Mengshu Zhang, Hong Li, Yanping Liu
Summary: The fetal origins of adult disease hypothesis suggests that events during early development can significantly affect an individual's risk for developing adult diseases. Peroxisome proliferator-activated receptors (PPARs), a type of nuclear hormone receptor, play a crucial role in the transition from embryo to fetus and are influenced by adverse events in early life. The methylation pattern of PPARs in offspring organs can affect development and health throughout life, and potentially impact future generations.
Review
Obstetrics & Gynecology
Carlos Briceno-Perez, Liliana Briceno-Sanabria, Carlos Briceno-Sanabria, Eduardo Reyna-Villasmil
Summary: The relationship between intrauterine events and later-life disease predisposition has been examined. Fetal exposure to high levels of corticosteroids, whether endogenous or synthetic, can modify physiological development and inhibit growth. Transcriptional changes in metabolic and growth pathways occur at the molecular level. Alterations in the placental methylation status of the 11 beta-hydroxysteroid dehydrogenase type 2 enzyme can result in increased cortisol exposure for the fetus. Improving the diagnosis and management of antenatal corticosteroid use may reduce long-term adverse outcomes. Further research is needed to understand the factors affecting fetal corticosteroid exposure and the potential use of placental methylation changes as biomarkers for disease risk.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Sarah Ellen Braun, Farah J. Aslanzadeh, Autumn Lanoye, Stephanie Fountain-Zaragoza, Mark G. Malkin, Ashlee R. Loughan
Summary: The study found that CogMed Working Memory Training is safe and acceptable in adult patients with glioma, with a moderate perceived benefit. While objectively improving working memory, some patients felt that the time commitment and intervention intensity may outweigh the benefits.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Psychology, Multidisciplinary
Sherry L. Pagoto, Molly E. Waring, Laurie C. Groshon, Aviana O. Rosen, Matthew W. Schroeder, Jared M. Goetz
Summary: This study evaluated the feasibility and acceptability of a dissonance-based social media intervention to promote sun safety in young adult tanners. The results showed that the intervention was effective in reducing indoor and outdoor tanning motivations and increasing motivations to use sunscreen and protective clothing. Additionally, the intervention led to a decrease in intentions to tan outdoors in the next year.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Sherry L. Pagoto, Molly E. Waring, Laurie C. Groshon, Aviana O. Rosen, Matthew W. Schroeder, Jared M. Goetz
Summary: This study conducted a randomized pilot trial to evaluate the feasibility and acceptability of a social media intervention in promoting sun safety behavior among young adult tanners. The results showed that the intervention was feasible and acceptable, with participants reporting increased motivation to engage in sun safety behaviors and decreased intentions to indoor and outdoor tanning.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Psychology, Clinical
William Grunewald, April R. R. Smith, Tiffany A. A. Brown
Summary: Cognitive behavioral therapy for ARFID (CBT-AR) may be effective in reducing the severity of ARFID symptoms among older adults with feeding tubes.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Psychology, Clinical
C. L. Verzijl, J. Duan, S. A. Wilfred, C. B. Becker, L. S. Kilpela
Summary: Despite historically focusing on youth, recent research shows that women of all ages experience body dissatisfaction and eating disorder issues. The proof-of-concept study on a modified intervention program for adult women indicates feasibility, acceptability, and potential positive effects on body image and related outcomes. Further research is warranted to investigate the efficacy of the program on a larger scale.
Article
History & Philosophy Of Science
Tatjana Buklijas, Salim Al-Gailani
Summary: Research on the long-term effects of the intrauterine environment has gained significant interest since the late 1980s. However, the focus on the maternal body as the driver of intergenerational ills has drawn criticism. This paper explains this narrowing of focus through the exchange between David Barker and the discipline of fetal physiology, and traces the history of these conceptualizations.
HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Youjin Kim, Yunsoo Kim, Jiyoung Hwang, Tim J. van den Broek, Bumjo Oh, Ji Yeon Kim, Suzan Wopereis, Jildau Bouwman, Oran Kwon
Summary: This study successfully predicted oxidative stress status in a healthy population using a machine learning algorithm combined with ten-fold cross-validation, with a proposed fine-tuned model including 16 features. External evaluation showed a high area under the curve of 0.949. Confirmation of discrimination power was achieved by applying the model to subjects with varying degrees of oxidative stress.
Article
Hematology
Christof Geisen, Mette Kjaer, Erika Fleck, Bjorn Skogen, Roisin Armstrong, Frank Behrens, Zubin Bhagwagar, Susanne Braeuninger, Anette Mortberg, Klaus Juel Olsen, Stephan Martin Gaston Schaefer, Carmen Walter, Erhard Seifried, Agneta Wikman, Jens Kjeldsen-Kragh, Michaela Koehm
Summary: This study investigated whether a single dose of anti-HPA-1a could accelerate the elimination of HPA-1ab platelets in healthy participants. The results showed that anti-HPA-1a significantly accelerated the elimination of HPA-1ab platelets in all participants, supporting its potential use in the prevention and treatment of FNAIT in pregnant women at risk.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Anja Melder, Esther Wittmann, Lucia Bulubas, Beate Dornheim, Katharina Kerber, Ulrike Vogelmann, Mattia Campana, Jasmin Hubert, Vivien Schmidt, Florian Heinen, Frank Padberg, Mirjam N. Landgraf
Summary: This study is the first-ever investigation of repetitive transcranial magnetic stimulation (rTMS) in Fetal Alcohol Spectrum Disorder (FASD). The results show that rTMS is safe, tolerable, and acceptable in pediatric patients with FASD. However, the individual improvements in functional cerebral domains and quality of life were not significant, and further clinical studies with larger samples are needed to determine effective stimulation protocols and evaluate treatment response.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Article
Surgery
Joanna Marantidis, David Song, Krishnan Venkatesan, Nathan M. Shaw
Summary: Adult-acquired buried penis (AABP) is a condition where a normal sized phallus is hidden due to excessive skin, fat, or tissue often caused by obesity, lymphedema, or trauma. Surgical repair is the standard treatment for AABP, but postoperative genital lymphedema can occur in up to 60% of patients. This article presents the use of indocyanine green (ICG) for lymphatic mapping as an adjunct to buried penis repair, offering new clinical insight into the use of lymphovenous bypass in AABP patients.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Article
Psychiatry
Jerome T. Galea, Carmen Contreras, Milagros Wong, Karen Ramos, Valentina Vargas, Hugo Sanchez, Renato A. Errea, Leonid Lecca, Molly F. Franke
Summary: This study pilot tested a basic depression care pathway for Adolescents living with HIV (ALWH) in Peru, to inform integration of depression care with HIV services. Preliminary results showed that 32% of participants eligible for Psychological First Aid accepted at least one session, with 33% being linked to specialized care.
GLOBAL MENTAL HEALTH
(2021)