Article
Spectroscopy
Haotian Xin, Yan Huang, Yanyan Han, Luyao Tang, Guiyi Yang, Yan Zhang, Songfang Zhao, Kang-Nan Wang, Yibing Li, Duxia Cao
Summary: A two-photon phosphorescent probe based on Ir(III) complex (Ir-CN) was designed and synthesized for the selective and sensitive detection of SO2 derivatives at subcellular level. The probe showed significant phosphorescent enhancement and increased phosphorescent lifetime, with a detection limit of 0.17 μM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Enrique Ortega-Forte, Samanta Hernandez-Garcia, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, Jose Ruiz, Fernando Gandia-Herrero
Summary: This study reports a novel mitochondria-targeted iridium(III) complex, OncoIr3, which exhibits advantageous properties as a bioimaging agent and shows potent anticancer activity in vitro and in vivo through an oncosis process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Applied
Zhiguo Zhang, Zhaoshi Chen, Chen Zhang, Wenyi Kang
Summary: This paper studied the physicochemical properties, antioxidant and anti-aging abilities of three new Tremella hydrocolloids. The physicochemical properties were characterized using various techniques. The antioxidant activities of the hydrocolloids were determined using radical scavenging assays. The anti-aging ability was investigated using the organism model of Caenorhabditis elegans. The results showed that ES-THD exhibited the highest radical scavenging capacity and anti-aging abilities.
Article
Chemistry, Applied
Dandan Chen, Tao Shao, Hongqing Zhao, Fengfeng Chen, Zhiyun Fang, Yupeng Tian, Xiaohe Tian
Summary: In this study, a novel cyclometallated iridium(III) complex (Ir-OH) with aggregation-induced emission (AIE) properties was developed for FLIM imaging-guided photodynamic therapy. The results showed that Ir-OH exhibited excellent fluorescence response to mitochondrial viscosity and had satisfactory multiphoton absorption properties in the near-infrared region. Changes in mitochondrial viscosity during photodynamic processes could be quantified in real-time by FLIM.
Article
Multidisciplinary Sciences
Wonjun Choi, Munkyu Kang, Jin Hee Hong, Ori Katz, Byunghak Lee, Guang Hoon Kim, Youngwoon Choi, Wonshik Choi
Summary: The authors present a flexible endoscope based on a bare fibre bundle and a lensless Fourier holographic imaging configuration to detect weak reflections from unstained biological tissues. The proposed endoscope allows calibration-free holographic image reconstruction and imaging through narrow and curved passages.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Inorganic & Nuclear
Hongdong Shi, Yi Wang, Simin Lin, Jingxue Lou, Qianling Zhang
Summary: Iridium complexes are widely used as molecular sensors due to their rich photophysical properties, such as large Stokes shifts, long emission lifetimes, environment-sensitive emissions, and high luminescence quantum yields. This paper reviews the recent development and application of iridium complexes as probes for various substances, and discusses the outlook for iridium-based probes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Tian Tian, Sha Xu, Yulu Ru, Daobin Zhang, Shouzhi Pu
Summary: A probe based on an iridium complex was developed for quantitative detection of HOCl, demonstrating excellent performance in the experiments.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Tian Tian, Sha Xu, Yulu Ru, Daobin Zhang, Shouzhi Pu
Summary: A red-emission Ir(III) complex-based probe was prepared for quantitative detection of HOCl with fast response, high selectivity, and stability, applicable for actual water samples.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiangtang Li, Hang Hu, Julia Laskin
Summary: In this study, a new integrated microfluidic probe (iMFP) was developed for high spatial resolution imaging of biological samples. The new probe design increased the robustness and throughput of imaging, making it suitable for high-resolution imaging of large tissue sections. This technology is important for understanding biological systems.
ANALYTICA CHIMICA ACTA
(2023)
Article
Spectroscopy
Xinya Hao, Jingting Zhan, Chen Geng, Weiying Lin
Summary: A new fluorescent probe was developed to detect changes in intracellular viscosity. The probe showed high sensitivity for viscosity measurement and demonstrated excellent performance in both living cells and tissues, indicating its wide potential applications in biomedicine.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Congcong Zhang, Haixiao Fang, Wei Du, Duoteng Zhang, Yunwei Qu, Fang Tang, Aixiang Ding, Kai Huang, Bo Peng, Lin Li, Wei Huang
Summary: In this study, a derivative of N,N-dimethyl-naphthalenamine was discovered to effectively detect MAO-A with high affinity and selectivity. It was also used for in situ imaging of MAO-A in living cells, enabling a comparison of the MAO-A content in human glioma and paracancerous tissues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Ramachandran Chelliah, Se Jin Park, Sungyoon Oh, Eunseok Lee, Eric Banan-Mwine Daliri, Fazle Elahi, Chae Rin Park, Ghazala Sultan, Inamul Hasan Madar, Deog Hwan Oh
Summary: This study found that fructo-oligosaccharides in banana peels had prebiotic effects and could be used as an antistress agent. In vitro and in vivo analysis showed that consumption of these oligosaccharides reduced stress and corticosterone levels, indicating an anxiolytic effect.
Article
Food Science & Technology
Pin-Hua Chen, Chun-Han Chang, Wei-Sheng Lin, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: Scope S-Allylcysteine (SAC) derived from aged garlic significantly improves mitochondrial dynamics in naturally aged mice and Caenorhabditis elegans, reducing oxidative stress and delaying aging. This study confirms that mitochondrial dynamics are a promising target for combating aging.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Cell Biology
Rabin Dhakal, Mohammad Yosofvand, Mahsa Yavari, Ramzi Abdulrahman, Ryan Schurr, Naima Moustaid-Moussa, Hanna Moussa
Summary: This paper reviewed the use of C. elegans as a model organism to study the biological effects of radiation, discussing the impact of radiation types, doses, and chemical substances on biological responses. Additionally, it explored how dietary components may enhance C. elegans resistance to ionizing radiation and increase their lifespan after exposure.
Article
Spectroscopy
Yibing Li, Yilin Zhu, Xuzi Cai, Jimin Guo, Cuiping Yao, Qiling Pan, Xuefeng Wang, Kang-Nan Wang
Summary: Research shows that the unbalanced metabolism of sulfur dioxide may lead to diseases such as neurological disorders and lung cancer. The developed Triph-SZ probe can detect SO2 derivatives and respond to changes in viscosity in lysosomes, providing a potential tool for monitoring HSO3 levels and viscosity changes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Mariano Soba, Gonzalo Scalese, Federico Casuriaga, Nicolas Perez, Nicolas Veiga, Gustavo A. Echeverria, Oscar E. Piro, Ricardo Faccio, Leticia Perez-Diaz, Gilles Gasser, Ignacio Machado, Dinorah Gambino
Summary: In this study, multifunctional Re(I) tricarbonyl compounds were designed as potential antichagasic drugs. These compounds showed activity against T. cruzi and demonstrated good selectivity towards the parasite compared to mammalian cells. The mechanism of action and physicochemical properties of these compounds were also investigated, showing promising potential for further drug development.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Organic
Capucine Mahe, Olivier Blacque, Gilles Gasser, Vincent Gandon, Kevin Cariou
Summary: The first synthesis of various N-metallocenyl ynamides has been achieved, along with the development of two strategies for the oxidative cyclization of N-ferrocenyl ynamide into ansa[3]-ferrocenylamide. The mechanism for the iodine(III)-triggered transformation has been investigated using DFT calculations, revealing a concerted iodination deprotonation step.
Review
Chemistry, Multidisciplinary
Hugo Madec, Francisca Figueiredo, Kevin Cariou, Sylvain Roland, Matthieu Sollogoub, Gilles Gasser
Summary: The development of organometallic catalysis has expanded the toolbox of synthetic chemists and paved the way for bio-compatible reactions in water. Performing metal-catalysed reactions within living cells or organisms poses additional constraints, requiring metal complexes with good efficiency, low concentration, cell specificity, cellular uptake, and low toxicity.
Article
Chemistry, Multidisciplinary
Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser, Liangnian Ji, Hui Chao
Summary: Conventional photodynamic therapy mainly affects primary tumors, while complementary immunotherapy is effective in eliminating small, non-localized tumors. We report the development of a highly potent immunogenic cell death inducing photosensitizer, Ir-pbt-Bpa, for two-photon photodynamic immunotherapy against melanoma. Upon light irradiation, Ir-pbt-Bpa can induce cell death through a combination of ferroptosis and immunogenic cell death, leading to a strong reduction in tumor size.
Article
Biochemistry & Molecular Biology
Youchao Wang, Patrick S. S. Felder, Pierre Mesdom, Olivier Blacque, Thomas L. L. Mindt, Kevin Cariou, Gilles Gasser
Summary: The synthesis and characterization of a ruthenium-rhenium binuclear complex, combining the photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex, is presented in this study for its potential use as a photosensitizer in anticancer photodynamic therapy. One of the complexes synthesized, which localized in mitochondria, showed selectivity towards human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29 cells, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
Article
Biochemistry & Molecular Biology
Germain Niogret, Alix Bouvier-Muller, Chiara Figazzolo, Jack M. Joyce, Frederic Bonhomme, Patrick England, Olena Mayboroda, Riccardo Pellarin, Gilles Gasser, James H. R. Tucker, Julian A. Tanner, G. Paul Savage, Marcel Hollenstein
Summary: Chemical modification of aptamers is important for improving their performance and stability. By combining enzymatic synthesis and nucleotides with bioisosteres, the synthetic burden of post-SELEX modification can be reduced and additional sequences with maintained binding but reduced specificity can be identified.
Review
Chemistry, Multidisciplinary
Yiyi Zhang, Bich-Thuy Doan, Gilles Gasser
Summary: This review systematically summarizes the effects of metal-based photosensitizers (PSs) on different types of regulated cell death (RCD), including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained, and commonalities between different metal-based PSs inducing the same RCD are emphasized. Future perspectives on metal-based PSs inducing novel forms of RCD are also discussed.
Editorial Material
Chemistry, Multidisciplinary
Gloria Vigueras, Gilles Gasser
Summary: Pharmacologically inactive prodrugs activated by near-infrared light have potential clinical applications. Platinum-based photo-oxidants have been shown to eliminate tumors in mice through a new mode of action.
Article
Nanoscience & Nanotechnology
Sarah Boumati, Angelique Sour, Valerie Heitz, Johanne Seguin, Gautier Beitz, Yusuke Kaga, Marta Jakubaszek, Johannes Karges, Gilles Gasser, Nathalie Mignet, Bich-thuy Doan
Summary: Researchers have successfully used a theranostic agent with combined diagnostic and therapeutic capabilities for photodynamic therapy, fluorescence imaging, and magnetic resonance imaging. The experimental results show that this theranostic agent has a significant impact on tumor growth and has the potential to become a drug candidate for cancer.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Silvio Jakopec, Lisa Gourdon-Grunewaldt, Ivona Cipor, Andrijana Mescic Macan, Berislav Peric, Ivo Piantanida, Kevin Cariou, Gilles Gasser, Srecko I. Kirin, Silvana Raic-Malic
Summary: Bioorganometallic complexes have shown promise for potential application in cancer treatment and diagnosis, as well as in bioimaging agents, with some acting as theranostic agents. A series of novel complexes with bidentate pyridyl-1,2,3-triazole and 2,2'-dipyridylamine ligands were prepared and characterized. The complexes exhibited interactions with biomacromolecules and showed significant antiproliferative activity on colon cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Fangmian Wei, Libing Ke, Siyuan Gao, Johannes Karges, Jinquan Wang, Yu Chen, Liangnian Ji, Hui Chao
Summary: Drug resistance and metastases are major causes of death in clinics. This study presents a novel strategy for the treatment of drug-resistant and metastatic tumors by using physical adsorption and oxidative polymerization of Pt(IV) prodrugs in pore-confined spaces of CaCO3 nanoparticles. The nanoparticles interact with cisplatin-resistant non-small lung cancer cells through multiple mechanisms, resulting in cell death by apoptosis, ferroptosis and immunogenic cell death.
Article
Chemistry, Inorganic & Nuclear
Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Summary: Novel diiron vinyliminium complexes were synthesized and characterized by various spectroscopic techniques. Their solubility in D2O, Log Pow coefficients, and stability in aqueous media were determined. The antiproliferative activity of these complexes on cancer cell lines was evaluated and their mechanism of action was investigated by assessing their influence on mitochondrial respiration.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yandong Ma, Zhihua Zhang, Fan Sun, Pierre Mesdom, Xin Ji, Pierre Burckel, Gilles Gasser, Min-Hui Li
Summary: Polymer micelles/vesicles made of a red-light-responsive block copolymer are developed as a model system for anticancer phototherapy. The system can release Ru complexes and generate ROS under red-light irradiation, leading to high cytotoxicity against cancer cells.
Article
Chemistry, Multidisciplinary
Youchao Wang, Pierre Burckel, Kallol Purkait, Bruno Saubamea, Pierre Burckel, Philippe Arnoux, Celine Frochot, Kevin Cariou, Thibaud Rossel, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a medical technique that uses non-toxic molecules called photosensitizers (PSs) for cancer treatment. This study introduces novel ruthenium and osmium polypyridyl complexes that can target carbonic anhydrases (CAs), which are overexpressed in cancer cells. These complexes accumulate in cancer cells and effectively kill them when irradiated with light. This research proposes a strategy to improve the selectivity of PDT.
Article
Chemistry, Multidisciplinary
Youchao Wang, Pierre Burckel, Kallol Purkait, Bruno Saubamea, Pierre Burckel, Philippe Arnoux, Celine Frochot, Kevin Cariou, Thibaud Rossel, Gilles Gasser
Summary: Photodynamic therapy is a medical technique that uses non-toxic molecules to selectively kill cancer cells when irradiated with light. This study presents novel complexes that target carbonic anhydrases, improving the selectivity of photodynamic therapy for cancer treatment.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
