4.8 Article

Eliminating Heat Injury of Zeolite in Hemostasis via Thermal Conductivity of Graphene Sponge

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 27, 页码 23848-23857

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b04956

关键词

zeolite; graphene; composite; hemostasis; thermal conduction

资金

  1. National Natural Science Foundation of China [21574008]
  2. China Postdoctoral Science Foundation [2018M641162]
  3. Fundamental Research Funds for the Central Universities [BHYC1705B, PYBZ1806]

向作者/读者索取更多资源

Thermal release of zeolite is conducive in hemostasis, but losing control will cause serious burns. How to balance the advantages and disadvantages is a challenge. Herein, a zeolite/cross-linked graphene sponge (Z-CGS) was design to break through this challenge. The CGS managed the heat release of zeolite by thermal conduction of graphene. Infrared thermal imager demonstrated the mild exothermic process and good thermal conductivity of the optimized Z-CGS. It controlled wound temperature below 42 degrees C effectively, as compared to 70 degrees C of naked zeolite. Blood clotting index further confirmed the contribution of thermal stimulation in Z-CGS. On the synergy of thermal and charge stimulations of zeolite, as well as physical adsorption of CGS, Z-CGS achieved outstanding hemostatic performance. Bleeding was stopped within 69 s in rat artery injury model, faster than that of the Quikclot Combat Gauze. Additionally, cytotoxicity assay and pathological analysis highlighted its biocompatibility. Z-CGS, therefore, was an outstanding composite of combining advantages of zeolite and graphene, while getting rid of the shortcomings of the basic unit. The thermal conductibility of graphene renews an avenue for the safe and highly efficient use of zeolite in hemostasis.

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