期刊
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
卷 52, 期 5, 页码 496-501出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0003683816050069
关键词
quaternized chitosan derivatives; melittin; warnerin; antibacterial activity; atomic force microscopy; force spectroscopy; nanoindentation
资金
- Russian Foundation for Basic Research [14-04-00687, 15-29-05858 ofi_m]
We obtained a number of conjugates based on a quaternized chitosan derivative and antimicrobial peptides (melittin and warnerin) crosslinked by microbial transglutaminase. We determined the optimal conditions for the synthesis (30 minutes, with a mole ratio of peptides and chitosan derivative of 1.4: 100) and studied the antibacterial properties of obtained conjugates. The antibacterial effect of the conjugates was found to be greater than that of their components. The antibacterial activity of the conjugates was determined by the double-dilution method and by atomic force microscopy.
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