Article
Biochemistry & Molecular Biology
Xiao Zhang, Tian-Ying Li, Hong-Mei Xiao, Kenneth C. Ehrlich, Hui Shen, Hong-Wen Deng, Melanie Ehrlich
Summary: The rising rates of obesity have prompted the search for obesity-related single nucleotide polymorphisms (SNPs) through genome-wide association studies (GWAS). This study used an epigenomic and transcriptomic analysis to identify potential regulatory SNPs in GWAS-derived SNPs related to obesity. The findings revealed novel regulatory SNPs and provided insights into the transcriptional regulation of obesity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Achinto Saha, Jill Hamilton-Reeves, John DiGiovanni
Summary: Obesity is a significant risk factor for prostate cancer, as it promotes the growth of white adipose tissue (WAT) and leads to more aggressive disease. Adipose stromal cells (ASCs) play a crucial role in driving the aggressiveness of prostate cancer by producing various factors, including the chemokine CXCL12. Understanding the mechanisms behind obesity-induced progression of prostate cancer has opened up opportunities for interventions to prevent or mitigate these critical events.
CANCER AND METASTASIS REVIEWS
(2022)
Review
Oncology
Shangzhi Feng, Kecheng Lou, Cong Luo, Junrong Zou, Xiaofeng Zou, Guoxi Zhang
Summary: This review focuses on the relationship between obesity and prostate cancer, as well as the role of exosomes. It has been found that there is bidirectional communication between obesity-related adipose tissue and prostate cancer. This review provides new directions for understanding obesity as a risk factor for prostate cancer and highlights the potential use of adipose tissue and exosomes in cancer treatment.
Article
Medicine, General & Internal
Julius Honecker, Stefan Ruschke, Claudine Seeliger, Samantha Laber, Sophie Strobel, Priska Proll, Christoffer Nellaker, Cecilia M. Lindgren, Ulrich Kulozik, Josef Ecker, Dimitrios C. Karampinos, Melina Claussnitzer, Hans Hauner
Summary: This study provides insights into the transcriptomic and FA landscape associated with adipocyte hypertrophy in adipose tissue. The development of non-invasive techniques, such as MRS, allows for the assessment of adipocyte size and FA composition in a clinical context, improving the phenotyping of adipose tissue in metabolic diseases.
Review
Biochemistry & Molecular Biology
Bamidele A. Adesunloye
Summary: Obesity is associated with the risk of prostate cancer through mechanisms such as chronic low-level inflammation and biological changes that promote malignant transformation. Understanding these mechanisms may be valuable in developing effective prostate cancer prevention strategies and treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
A. C. Ludzki, M. W. Schleh, E. M. Krueger, N. M. Taylor, B. J. Ryan, T. C. Baldwin, J. B. Gillen, C. Ahn, P. Varshney, J. F. Horowitz
Summary: This study compared the effects of a single session of high-intensity interval exercise versus moderate-intensity continuous exercise on transcriptional changes in subcutaneous abdominal adipose tissue collected from adults with obesity. The novel findings indicate exercise upregulated inflammation-related gene sets and downregulated metabolism-related gene sets in both high-intensity and moderate-intensity exercise sessions, suggesting exercise can impact inflammation and metabolism in adipose tissue transcriptome 1 hour after exercise.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Surgery
M. Ismaiel, B. Murphy, C. Hayes, L. O'Connell, D. C. Winter
Summary: Visceral obesity is a risk factor for colorectal cancer, and weight loss can reduce the risk.
BRITISH JOURNAL OF SURGERY
(2022)
Review
Oncology
Ibrahim AlZaim, Aya Al-Saidi, Safaa H. Hammoud, Nadine Darwiche, Yusra Al-Dhaheri, Ali H. Eid, Ahmed F. El-Yazbi
Summary: As overweight and obesity increase, the number of individuals diagnosed with prostate cancer also rises. The increase in fat tissue can lead to inflammation, which may increase the aggressiveness of prostate cancer. The production of blood clotting factors is also increased in obesity, fat tissue inflammation, and prostate cancer. This article explores the role of these clotting factors in the progression of prostate cancer due to increased body weight and proposes new treatment approaches.
Review
Oncology
Anouk A. S. van den Bosch, Johanna M. A. Pijnenborg, Andrea Romano, Bjorn Winkens, Louis J. M. van der Putten, Roy F. P. M. Kruitwagen, Henrica M. J. Werner
Summary: This systematic review found that adipose tissue (AT) distribution plays a significant role in the development and prognosis of endometrial cancer (EC), correlating with obesity measures, histological subtypes, lymph node metastasis, and sex steroid levels. Further well-designed prospective studies are needed to explore these differences more specifically and understand how it can contribute to the prediction and therapy of EC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shiqi Li, Fuhui Zhang, Xiuchan Xiao, Yanzhi Guo, Zhining Wen, Menglong Li, Xuemei Pu
Summary: Prostate cancer is a major cause of cancer-related deaths, and current monotherapies show limited efficacy. Transcriptomics-based and network-based prediction models can be used to quickly screen potential drug combinations and assess their effectiveness through in vitro experiments. For Prostate cancer, the transcriptomics-based method outperforms the network-based one, providing guidance for selecting computational methods in drug combination screening.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Li Zhang, Peng Ma, Zijing Wang, Tianshu Xu, Sin Man Lam, Guanghou Shui, Yuzhen Wang, Jiming Xie, Guifen Qiang
Summary: Using a multiomics approach, this study explored the mechanism of thermogenesis in BAT, revealing a high abundance of glycerophospholipids and sphingolipids in BAT. The study also identified specific lipid biomarkers and gene biomarkers that may serve as potential targets for antiobesity drugs by boosting BAT thermogenesis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Said Boujraf, Mohamed Chikri
Summary: Understanding the role of white adipose tissue (WAT) in metabolic syndrome, including obesity and type 2 diabetes (T2D), is important. Insulin resistance plays a key role in the development of T2D. The comparison of WAT differences between obese diabetics and obese individuals with normal glucose tolerance and insulin resistance can provide insights into the molecular pathways underlying the development of obesity-related T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Kristy A. Brown, Philipp E. Scherer
Summary: Adipose tissue, as the largest endocrine organ, has been strongly linked to cancer development due to the metabolic dysfunction and insulin resistance caused by increased adiposity. Adipose tissue also directly impacts the development and progression of specific cancers, such as breast cancer. Changes in factor secretion and adipose tissue remodeling contribute to the obesity-cancer link. Additionally, adipose tissue provides essential nutrients for tumor cells through increased lipolysis and aerobic glycolysis. This article aims to provide an update on the role of adipose tissue in cancer initiation and progression.
Article
Oncology
Xingchen Dai, Xinyi Shi, Mingxiu Luo, Pu Li, Yujing Gao
Summary: The study identified the altered arginine and proline metabolism pathway in castration-resistant prostate cancer (CRPC) through transcriptomic and metabolomic analysis. These findings provide important insights for the clinical management of CRPC.
Review
Medicine, General & Internal
Bei Li, Si Sun, Juan-Juan Li, Jing-Ping Yuan, Sheng-Rong Sun, Qi Wu
Summary: Obesity is a serious global health problem that is closely associated with the development of cancer. Adipose tissue macrophages (ATMs) play a crucial role in linking obesity-related inflammation and tumor progression. However, the functions of ATMs in obesity-associated cancer progression are not yet fully understood. In this review, we discuss the origins, phenotypes and functions of ATMs, as well as potential mechanisms underlying their reprogramming in the obesity-associated microenvironment. Understanding the properties and functions of ATMs in obesity will contribute to the development of new therapeutic interventions for obesity-related cancer.
MILITARY MEDICAL RESEARCH
(2023)
Article
Oncology
Emily J. Lelliott, Stefano Mangiola, Kelly M. Ramsbottom, Magnus Zethoven, Lydia Lim, Peter K. H. Lau, Amanda J. Oliver, Luciano G. Martelotto, Laura Kirby, Claire Martin, Riyaben P. Patel, Alison Slater, Carleen Cullinane, Anthony T. Papenfuss, Nicole M. Haynes, Grant A. McArthur, Jane Oliaro, Karen E. Sheppard
Summary: Combined inhibition of BRAF, MEK, and CDK4/6 in melanoma patients with BRAF(V600) mutation shows potent tumor control effects but may lead to resistance to immune checkpoint blockade.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Ken Chow, Justin Bedo, Andrew Ryan, Dinesh Agarwal, Damien Bolton, Yee Chan, Philip Dundee, Mark Frydenberg, Marc A. Furrer, Jeremy Goad, Dennis Gyomber, Uri Hanegbi, Laurence Harewood, Dennis King, Alastair D. Lamb, Nathan Lawrentschuk, Peter Liodakis, Daniel Moon, Declan G. Murphy, Justin S. Peters, Paul Ruljancich, Clare L. Verrill, David Webb, Lih-Ming Wong, Homayoun Zargar, Anthony J. Costello, Anthony T. Papenfuss, Christopher M. Hovens, Niall M. Corcoran
Summary: Ductal adenocarcinoma, an uncommon variant of prostate cancer, is associated with worse clinical outcomes. Patients with ductal variant histology demonstrated shorter salvage-free survival and metastasis-free survival. RB1 loss and copy number gains in TAP1, SLC4A2, and EHHADH were consistently associated with ductal variant histology.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E. Tiedje, Virginie Rougeron, Michael F. Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H. Branch, Lastenia Ruiz-Mesia, Thomas S. Rask, Franck Prugnolle, Anthony T. Papenfuss, Yao-ban Chan, Karen P. Day
Summary: The researchers developed a computational approach to explore the evolution of specific DNA sequences of the major VSA gene of the human malaria parasite, Plasmodium falciparum, successfully distinguishing DNA signatures specific to each species and identifying geographic signatures related to the out of Africa origin of P. falciparum.
Article
Oncology
Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams, Anthony J. Costello, Paul J. Neeson, Bhupinder Pal, Nicholas D. Huntington, Niall M. Corcoran, Anthony T. Papenfuss, Christopher M. Hovens
Summary: This study reveals the important role of monocytes and macrophages in the progression and recurrence of prostate cancer through analysis of the tumor microenvironment. The findings were validated by spatial analyses at the single-cell level using multiplex immunohistochemistry. This study advances our understanding of the immune modulation within the prostate microenvironment and their impact on disease progression and patient survival.
Article
Oncology
Patrick McCoy, Stefano Mangiola, Geoff Macintyre, Ryan Hutchinson, Ben Tran, Bernard Pope, Peter Georgeson, Matthew K. H. Hong, Natalie Kurganovs, Sebastian Lunke, Michael J. Clarkson, Marek Cmero, Michael Kerger, Ryan Stuchbery, Ken Chow, Izhak Haviv, Andrew Ryan, Anthony J. Costello, Niall M. Corcoran, Christopher M. Hovens
Summary: Recent studies have shown that patients with defects in the DNA mismatch repair pathway driven by MSH2 or MSH6 loss experience increased incidence of prostate cancer. However, the presence of loss or reduced levels of MSH2/MSH6 protein in prostate cancer is associated with poor outcomes, although this does not correlate with a statistically significant increase in mutational burden, microsatellite instability, or immune cell mobilisation in a primary cohort of prostate cancers.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Jean Berthelet, Verena C. Wimmer, Holly J. Whitfield, Antonin Serrano, Thomas Boudier, Stefano Mangiola, Michal Merdas, Farrah El-Saafin, David Baloyan, Jordan Wilcox, Steven Wilcox, Adam C. Parslow, Anthony T. Papenfuss, Belinda Yeo, Matthias Ernst, Bhupinder Pal, Robin L. Anderson, Melissa J. Davis, Kelly L. Rogers, Frederic Hollande, Delphine Merino
Summary: The study optimized the use of optical barcoding to visualize and characterize cancer subclones, revealing that lung metastases were highly polyclonal while liver metastases were not. The transcriptome of the subclones varied according to their metastatic niche, indicating that the heterogeneity observed in metastases is largely dictated by the tumor microenvironment.
Article
Surgery
Marc A. Furrer, Anne Hong, David Wetherell, Stefan B. Heinze, Paul Simkin, Ken Chow, Nathan Lawrentschuk, Homayoun Zargar
Summary: In this study, IB-MRGB played an important role in the diagnosis of clinically significant prostate cancer. Based on mpMRI results, IB-MRGB accurately detected csPCa, with a low rate of complications.
ANZ JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Chol-Hee J. Jung, Paul C. M. Boutros, Daniel J. M. Park, Niall M. M. Corcoran, Bernard J. M. Pope, Christopher M. M. Hovens
Summary: The question of attributing authorship to deceased individuals in the biomedical literature is controversial. Guidelines for authorship lack consensus, and the prevalence of this practice has not been systematically quantified. A study quantified the prevalence of publications by deceased authors in the biomedical literature and found a rapid increase in the number of deceased publications. More than 50% of deceased author papers were first submitted after the author's death, and over 60% of these papers failed to acknowledge the deceased authors. The study concludes that a consensus framework is needed to address authorship by deceased scientists.
Article
Multidisciplinary Sciences
Stefano Mangiola, Alexandra J. Roth-Schulze, Marie Trussart, Enrique Zozaya-Valdes, Mengyao Ma, Zijie Gao, Alan F. Rubin, Terence P. Speed, Heejung Shim, Anthony T. Papenfuss
Summary: Cellular omics allows the characterization of tissue and microbial community composition, which is critical for identifying markers of disease progression. However, existing methods for differential composition analysis in cellular omics data have limitations in modeling compositional data properties. In this study, a method called sccomp is introduced, which addresses these limitations and improves the performance of analyzing differential composition and variability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemical Research Methods
Md Abdullah Al Kamran Khan, Jian Wu, Yuhan Sun, Alexander D. Barrow, Anthony T. Papenfuss, Stefano Mangiola
Summary: cellsig is a Bayesian sparse multilevel model designed to improve signature estimation by adjusting data for multilevel effects and modeling for gene-set sparsity. This approach significantly enhances cell-type marker gene ranking performance and has implications for marker gene validation and single-cell annotation. The codes and database for cellsig are available online for further research and implementation.
Article
Genetics & Heredity
Yu Jiang, Travis J. Meyers, Adaeze A. Emeka, Lauren Folgosa Cooley, Phillip R. Cooper, Nicola Lancki, Irene Helenowski, Linda Kachuri, Daniel W. Lin, Janet L. Stanford, Lisa F. Newcomb, Suzanne Kolb, Antonio Finelli, Neil E. Fleshner, Maria Komisarenko, James A. Eastham, Behfar Ehdaie, Nicole Benfante, Christopher J. Logothetis, Justin R. Gregg, Cherie A. Perez, Sergio Garza, Jeri Kim, Leonard S. Marks, Merdie Delfin, Danielle Barsa, Danny Vesprini, Laurence H. Klotz, Andrew Loblaw, Alexandre Mamedov, S. Larry Goldenberg, Celestia S. Higano, Maria Spillane, Eugenia Wu, H. Ballentine Carter, Christian P. Pavlovich, Mufaddal Mamawala, Tricia Landis, Peter R. Carroll, June M. Chan, Matthew R. Cooperberg, Janet E. Cowan, Todd M. Morgan, Javed Siddiqui, Rabia Martin, Eric A. Klein, Karen Brittain, Paige Gotwald, Daniel A. Barocas, Jeremiah R. Dallmer, Jennifer B. Gordetsky, Pam Steele, Shilajit D. Kundu, Jazmine Stockdale, Monique J. Roobol, Lionne D. F. Venderbos, Martin G. Sanda, Rebecca Arnold, Dattatraya Patil, Christopher P. Evans, Marc A. Dall'Era, Anjali Vij, Anthony J. Costello, Ken Chow, Niall M. Corcoran, Soroush Rais-Bahrami, Courtney Phares, Douglas S. Scherr, Thomas Flynn, R. Jeffrey Karnes, Michael Koch, Courtney Rose Dhondt, Joel B. Nelson, Dawn McBride, Michael S. Cookson, Kelly L. Stratton, Stephen Farriester, Erin Hemken, Walter M. Stadler, Tuula Pera, Deimante Banionyte, Fernando J. Bianco, Isabel H. Lopez, Stacy Loeb, Samir S. Taneja, Nataliya Byrne, Christopher L. Amling, Ann Martinez, Luc Boileau, Franklin D. Gaylis, Jacqueline Petkewicz, Nicholas Kirwen, Brian T. Helfand, Jianfeng Xu, Denise M. Scholtens, William J. Catalona, John S. Witte
Summary: Men diagnosed with low-risk prostate cancer who initially choose active surveillance may eventually convert to active treatment due to genetic factors that predispose to aggressive tumors. This study identified genetic variants associated with conversion from active surveillance to active treatment, suggesting that germline genetics may help individualize management decisions for low-risk prostate cancer.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Article
Genetics & Heredity
Stefano Mangiola, Evan A. Thomas, Martin Modrak, Aki Vehtari, Anthony T. Papenfuss
Summary: Relative transcript abundance is a valuable tool for gene function understanding. The negative binomial model is commonly used for transcript abundance analysis, but lacks robustness to extreme outliers. Rigorous methods for outlier detection in RNA sequencing data are yet to be developed.
NAR GENOMICS AND BIOINFORMATICS
(2021)
Article
Oncology
Marek Cmero, Natalie J. Kurganovs, Ryan Stuchbery, Patrick McCoy, Corrina Grima, Anne Ngyuen, Ken Chow, Stefano Mangiola, Geoff Macintyre, Nicholas Howard, Michael Kerger, Philip Dundee, Paul Ruljancich, David Clarke, Jeremy Grummet, Justin S. Peters, Anthony J. Costello, Sam Norden, Andrew Ryan, Phillip Parente, Christopher M. Hovens, Niall M. Corcoran
Summary: The study found that resistance following short-term treatment differs molecularly from typical progressive castration-resistant disease, associated with transcriptional reprogramming, to a transitional epithelial-to-mesenchymal transition (EMT) phenotype rather than an upregulation of AR signaling. Unexpectedly, tolerance to therapy appears to be the default state, with treatment response correlating with the prevalence of tumor cells deficient for SNAI2, a key regulator of EMT reprogramming.
JCO PRECISION ONCOLOGY
(2021)
Article
Urology & Nephrology
Edmond M. Kwan, Heidi Fettke, Maria M. Docanto, Sarah Q. To, Patricia Bukczynska, Andrew Mant, David Pook, Nicole Ng, Lisa-Jane K. Graham, Stefano Mangiola, Eva Segelov, Kate Mahon, Ian D. Davis, Phillip Parente, Carmel Pezaro, Tilman Todenhoefer, Lisa G. Horvath, Arun A. Azad
Summary: The study aimed to develop a prognostic whole-blood gene signature for mCRPC patients by analyzing gene expression in patient samples. The results showed that the gene signature based on certain genes associated with the androgen receptor had strong prognostic utility in predicting survival outcomes for patients starting contemporary systemic therapies.
EUROPEAN UROLOGY FOCUS
(2021)