Review
Allergy
Katherine A. Owen, Amrie C. Grammer, Peter E. Lipsky
Summary: It has been found that patients of non-European ancestry experience more severe systemic lupus erythematosus (SLE) with different responses to standard medications. Despite extensive research, it remains unclear why ancestry remains a key determinant of poorer outcomes for non-European-ancestry patients. Novel bioinformatic and pathway-based approaches have shed light on the complex genetic architecture linking ancestry to SLE susceptibility.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Orthopedics
G. Aubourg, S. J. Rice, P. Bruce-Wootton, J. Loughlin
Summary: Osteoarthritis genetics has made significant progress through large-scale genome-wide association scans. Over 100 genetic risk variants associated with osteoarthritis have been identified, accounting for more than 20% of its heritability. These variants are mainly located in non-protein coding regions of the genome and regulate the expression of target genes. Epigenetic factors, particularly cartilage DNA methylation changes, are also correlated with some of these variants, suggesting a potential mediation of genetic effects on gene expression.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Nutrition & Dietetics
Li Liu, Yuansi Chen, Jiaxin Chen, Ming Lu, Rui Guo, Jiajia Han, Yu Zhang, Xiaoting Pei, Zhiguang Ping
Summary: The methylation levels of PRDM16 gene promoter in abdominal subcutaneous adipose tissue (SAT) and omental adipose tissue (OAT) have complex relationships with overweight/obesity, with differences in methylation levels between different weight groups and different adipose tissue types. The variation of methylation haplotypes combination of multiple sites may play some roles in influencing obesity.
CLINICAL NUTRITION
(2021)
Article
Genetics & Heredity
Lili Du, Tianpeng Chang, Bingxing An, Mang Liang, Tianyu Deng, Keanning Li, Sheng Cao, Yueying Du, Xue Gao, Lingyang Xu, Lupei Zhang, Junya Li, Huijiang Gao
Summary: Genetics and environment play a role in fat deposition traits, affecting meat quality, growth rate, and energy metabolism in livestock. However, the molecular mechanism of fat deposition in beef cattle is not fully understood. This study analyzed transcriptomics and lipid metabolomics of different adipose tissues in Huaxi cattle, uncovering gene expression patterns and metabolite differences. Several candidate genes, such as SCD, ELOVL6, ACACA, and FABP7, were found to regulate fat deposition by influencing the levels of fatty acids and triglycerides. These findings provide valuable insights for future research on fat deposition in beef cattle.
Article
Biochemistry & Molecular Biology
Hailiang Zhang, Siyuan Mi, Luiz F. Brito, Lirong Hu, Lei Wang, Longgang Ma, Qing Xu, Gang Guo, Ying Yu, Yachun Wang
Summary: The study aims to identify key candidate genes regulating subcutaneous fat deposition in high-producing dairy cows by integrating genomic and transcriptomic datasets. GWAS and WGCNA are performed to identify genes associated with subcutaneous fat deposition. Differentially expressed genes and overlapping genes are also analyzed. The candidate genes are significantly enriched for pathways involved in metabolism, oxidative phosphorylation, thermogenesis, fatty acid degradation, and glycolysis/gluconeogenesis pathways. NID2, STARD3, UFC1, DEDD, PPP1R1B, and USP21 are considered the most important candidate genes influencing subcutaneous fat deposition traits in Holstein cows.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Biology
Yan Gong, Jun He, Biao Li, Yu Xiao, Qinghua Zeng, Kang Xu, Yehui Duan, Jianhua He, Haiming Ma
Summary: This study reveals the transcription profiles and functional networks in lncRNA and mRNA in subcutaneous adipose tissue of Ningxiang piglets at different developmental stages. Most DEmRNAs were up-regulated in piglets, while they were down-regulated in late fattening stages, with DElncRNAs being up-regulated in late fattening stages. Modules 2 and 5 exhibit similar transcription modes, mainly involved in steroid biosynthesis, glycosphingolipid biosynthesis, metabolic pathways, and glycerolipid metabolism.
Article
Developmental Biology
Ivelisse Cajigas, Abhijit Chakraborty, Madison Lynam, Kelsey R. Swyter, Monique Bastidas, Linden Collens, Hao Luo, Ferhat Ay, Jhumku D. Kohtz
Summary: The study reveals that Evf2 interacts with factors like Sox2 to regulate gene expression on chromosome 6 in mice. The interactions between Evf2 and Sox2 influence the activity of Dlx5/6UCE, ultimately affecting gene expression.
Article
Physiology
A. C. Ludzki, M. W. Schleh, E. M. Krueger, N. M. Taylor, B. J. Ryan, T. C. Baldwin, J. B. Gillen, C. Ahn, P. Varshney, J. F. Horowitz
Summary: This study compared the effects of a single session of high-intensity interval exercise versus moderate-intensity continuous exercise on transcriptional changes in subcutaneous abdominal adipose tissue collected from adults with obesity. The novel findings indicate exercise upregulated inflammation-related gene sets and downregulated metabolism-related gene sets in both high-intensity and moderate-intensity exercise sessions, suggesting exercise can impact inflammation and metabolism in adipose tissue transcriptome 1 hour after exercise.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiziana Caputo, Van Du T. Tran, Nasim Bararpour, Carine Winkler, Gabriela Aguileta, Khanh Bao Trang, Greta M. P. Attianese, Anne Wilson, Aurelien Thomas, Marco Pagni, Nicolas Guex, Beatrice Desvergne, Federica Gilardi
Summary: Chronic inflammation in metabolic organs, such as white adipose tissue, is a major factor in obesity-related health issues. High-fat diets trigger different responses in visceral and subcutaneous adipose tissue, with the former experiencing limited expansion due to antiadipogenic signals and the latter allowing storage of excessive fatty acids. Differential regulation of adipocyte number and differentiation in response to obesogenic stimuli plays a crucial role in the susceptibility to obesity-related inflammation between visceral and subcutaneous adipose tissue depots.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ali Oghabian, Birgitta W. van der Kolk, Pekka Marttinen, Armand Valsesia, Dominique Langin, W. H. Saris, Arne Astrup, Ellen E. Blaak, Kirsi H. Pietilainen
Summary: This study predicts the success of diet-induced weight loss based on gene expression in subcutaneous adipose tissue. The genes associated with lipid metabolism and response to virus were found to significantly differ between high and low weight loss groups at baseline. Machine learning models using these genes accurately predicted weight loss outcomes.
Article
Immunology
Jean-Philippe Bastard, Veronique Pelloux, Rohia Alili, Soraya Fellahi, Judith Aron-Wisnewsky, Emilie Capel, Bruno Feve, Lambert Assoumou, Edi Prifti, Christine Katlama, Karine Clement, Jacqueline Capeau
Summary: By switching ART-controlled persons living with HIV from a protease inhibitor regimen to raltegravir/maraviroc, the study found that while systemic insulin resistance increased, there was a tendency for increased adipocyte size and enhanced adipogenesis-related gene profile in SCAT. Furthermore, there was a decrease in the overall expression of genes related to immune activation/inflammation.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Mireia Bustos-Aibar, Augusto Anguita-Ruiz, Alvaro Torres-Martos, Jesus Alcala-Fdez, Francisco Javier Ruiz-Ojeda, Marjorie Reyes-Farias, Andrea Soria-Gondek, Laura Herrero, David Sanchez-Infantes, Concepcion Maria Aguilera
Summary: Childhood obesity, a multifactorial disease impacting various metabolic disorders, was investigated through RNAseq analysis of adipose tissue samples. The study identified unique and shared gene expression patterns in VAT and SAT associated with overweight and obesity in children.
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, PT I
(2022)
Editorial Material
Oncology
C. Simon Herrington, Richard Poulsom, Hartmut Koeppen, Philip J. Coates
Summary: The 2021 Annual Review Issue of The Journal of Pathology features 14 invited reviews on current research areas in pathology, covering topics like the impact of the COVID-19 pandemic, biomarkers for immune checkpoint inhibitors, and advances in nucleic acid detection. Authored by experts in academia and industry, the reviews offer comprehensive updates on these areas with recent progress.
JOURNAL OF PATHOLOGY
(2021)
Article
Genetics & Heredity
Kenneth C. Ehrlich, Hong-Wen Deng, Melanie Ehrlich
Summary: Striated muscle has high energy demands. 97 genes expressed in skeletal muscle and heart, but not in aorta, were found to be associated with mitochondria. These genes showed correlations between their tissue-specific transcription levels, chromatin state, and DNA methylation, providing new insights into transcription control.
Article
Biochemistry & Molecular Biology
Kenneth C. Ehrlich, Carl Baribault, Melanie Ehrlich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)