Review
Chemistry, Physical
Robin Augustine, Abdulla Al Mamun, Anwarul Hasan, Shaheen Abdul Salam, Ramya Chandrasekaran, Rashid Ahmed, Avnesh S. Thakor
Summary: The application of nanostructured materials in medicine, particularly in cancer diagnosis, shows great promise in aiding early detection, treatment, and patient follow-up. The tunable physical, chemical, and biological properties of nanomaterials make them highly desirable for diagnosing and treating various diseases, including cancers.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jung Jae Park, Chan Kyo Kim
Summary: This article reviews recent literature on the diagnostic value of pre-biopsy prostate MRI as a triage tool and discusses unresolved issues regarding the paradigm shift in the diagnosis of prostate cancer.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Chemistry, Physical
Salar Khaledian, Farhad Nalaini, Mahmood Mehrbakhsh, Mohadese Abdoli, Saleh Salehi Zahabi
Summary: Quantum dots, as a type of zero dimensional nanostructure, play an important role in the field of bioimaging due to their unique optical properties and wide applications. Recently, quantum dots derived from two-dimensional nanostructures have received more attention for their more stable fluorescence, less toxicity, and eco-friendly properties.
Article
Multidisciplinary Sciences
Kazushige Sakaguchi, Michikata Hayashida, Naoto Tanaka, Suguru Oka, Shinji Urakami
Summary: This study developed a risk model for detecting clinically significant prostate cancer (sPC) based on clinical parameters and bi-parametric magnetic resonance imaging (bpMRI) results in a Japanese cohort. The risk model, including age, log prostate-specific antigen, prostate volume, and PI-RADS scores, outperformed individual parameters alone in predicting sPC.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
I. Jennifer Gomez, Karina Ovejero-Paredes, Jose Manuel Mendez-Arriaga, Nadezda Pizurova, Marco Filice, Lenka Zajickova, Sanjiv Prashar, Santiago Gomez-Ruiz
Summary: Due to their water solubility, stability, non-toxicity, and photoluminescence, nitrogen-doped graphene quantum dots (NGQDs) have potential for delivering organotin(IV) compounds in cancer therapy. Two nanosystems were developed by grafting organotin fragments and 4-formylbenzoic acid onto the surface of NGQDs. In vitro tests demonstrated high cytotoxicity against breast cancer cells (MDA-MB-231) and minimal effects on non-cancer cells (HEK293T), with successful uptake and release of the metallodrug in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Purnima Gogoi, Geetika Kaur, Nikhlesh K. Singh
Summary: Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer-related mortality in the United States. Nanotechnology plays a vital role in CRC treatment, offering targeted chemotherapies and improved chances of patient survival. Nanoparticles also have potential for simultaneous diagnosis and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Analytical
Huijuan Yan, Shuo Yang, Mengxue Liu, Ke Bao, Wu Ren, Fei Lin, Yiqiao Gao, Zhenghui Wang, Shuanghui Liu, Jieli Lv, Ying Zhao
Summary: Targeted imaging using graphene quantum dots (GQDs) as biosensors shows promise for early-stage cancer detection. However, existing GQDs have limitations such as low two-photon absorption and narrow spectral coverage. In this study, a hybrid with high fluorescence and two-photon imaging performance, composed of GQDs and silica nanoparticles (SiO2 NPs), was developed. By further modifying this hybrid with aptamer Sgc8c, it exhibited specific responses to target cells and could be used as a signal-amplifying two-photon nanoprobe for targeted cancer imaging. This signal amplification strategy holds great potential for accurate early tumor diagnosis and broader clinical applications.
Article
Chemistry, Multidisciplinary
Yujia Zheng, Qianqian Li, Jing Wu, Ziyi Luo, Wenyi Zhou, Anguo Li, Yanling Chen, Tuerxunayi Rouzi, Tian Tian, Hui Zhou, Xiaodong Zeng, Yang Li, Xiaoding Cheng, Yongchang Wei, Zixin Deng, Fuling Zhou, Xuechuan Hong
Summary: Novel NIR-II small-molecule probe H4-PEG-Glu showed effective imaging and treatment targeting mitochondria in acute myeloid leukemia cells, inducing cell apoptosis and exhibiting moderate cytotoxicity without laser irradiation. Enhanced chemo- and photothermal therapy effects were observed with laser irradiation, presenting high synergistic effects in vivo and specific tumor imaging in AML patient-derived PDX mouse models.
Article
Oncology
Yuan-Yuan Zhu, Liang Song, Yong-Qu Zhang, Wan-Ling Liu, Wei-Ling Chen, Wen-Liang Gao, Li-Xin Zhang, Jia-Zheng Wang, Zi-He Ming, Yun Zhang, Guo-Jun Zhang
Summary: This study developed a novel near-infrared in vivo fluorescence imaging system that can accurately detect breast cancer metastasis to the Sentinel lymph node (SLN). By combining erbium-based rare-earth nanoparticles with a peptide antagonist, the system was able to visualize metastatic tumor cells in real-time and significantly improve the detection rate of SLN metastasis.
Article
Pharmacology & Pharmacy
Nahid S. Awad, Mohamed Haider, Vinod Paul, Nour M. AlSawaftah, Jayalakshmi Jagal, Renu Pasricha, Ghaleb A. Husseini
Summary: The study successfully encapsulated hydrophilic graphene quantum dots in stealth liposomes and triggered their release using low-frequency ultrasound, providing an effective method to deliver QDs to tumor cells while reducing systemic toxicity.
Article
Oncology
Xiaobin Wei, Li Zhu, Yanyan Zeng, Ke Xue, Yongming Dai, Jianrong Xu, Guiqin Liu, Fang Liu, Wei Xue, Dongmei Wu, Guangyu Wu
Summary: This study evaluated the performance of DR-CSI combined with SVM in detecting prostate cancer. The results showed that the DR-CSI model outperformed ADC and T-2 values in the exploration stage. The validation stage determined the requirements for mapping. In the test stage, DR-CSI showed higher diagnostic performance than PI-RADS and GE; 3 for both patients and lesions, as well as PI-RADS and GE; 4 for lesions. DR-CSI also had higher accuracy than PI-RADS and GE; 3 for clinically significant PCa.
Article
Chemistry, Physical
Mohamed Haider, Roberta Cagliani, Jayalakshmi Jagal, Manju N. Jayakumar, Bahgat Fayed, Sarra B. Shakartalla, Renu Pasricha, Khaled Greish, Raafat El-Awady
Summary: This study aimed to develop a targeted nanotheranostic agent for early diagnosis and inhibition of malignant progression in colorectal cancer. Covalently labeled graphene oxide quantum dots showed increased targeting and specific uptake in colorectal cancer cells expressing the PLAC-1 antigen, leading to enhanced cell cytotoxicity and reduced invasiveness. This highlights the potential use of these targeted nanoparticles for detection and treatment of colorectal cancer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Optics
Mohammad Jafar Molaei
Summary: Curcumin-containing turmeric was used to synthesize Gd-doped carbon quantum dots (CQDs), which showed functionalization with Gd-containing drug and oxygen-containing functional groups. The Gd-doped CQDs exhibited excitation wavelength-dependent photoluminescence and positive contrast in T1-weighted magnetic resonance imaging (MRI). These findings suggest that Gd-doped CQDs can be used as a multi-modal imaging agent for fluorescence imaging and MRI.
JOURNAL OF LUMINESCENCE
(2023)
Article
Multidisciplinary Sciences
Artem N. Abramov, Igor Y. Chestnov, Ekaterina S. Alimova, Tatiana Ivanova, Ivan S. Mukhin, Dmitry N. Krizhanovskii, Ivan A. Shelykh, Ivan V. Iorsh, Vasily Kravtsov
Summary: By using local deformation of monolayer WSe2, we have successfully created high-purity single-photon emitters. Through nanoindentation and atomic force microscopy, we have identified the single-photon emitting sites and reconstructed the details of the surrounding local strain potential. The experimental results suggest that the single-photon emission is likely due to strain-induced spectral shift of dark excitonic states and their hybridization with localized states of individual defects.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Heinz-Peter Schlemmer, Bernd Joachim Krause, Viktoria Schuetz, David Bonekamp, Sarah Marie Schwarzenboeck, Markus Hohenfellner
Summary: Currently, multiparametric MRI and MR/TRUS fusion biopsy significantly improve the detection of clinically significant prostate cancer, while PSMA hybrid imaging aids in the staging of high-risk patients and detection of recurrences.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Jiani Yu, Weitao Yang, Shige Xing, Jun Wang, Huanxing Han, Pengfei Zhang, Chenyang Xiang, Bingbo Zhang
Article
Chemistry, Multidisciplinary
Peiru Wang, Weitao Yang, Shuzhan Shen, Chao Wu, Long Wen, Qian Cheng, Bingbo Zhang, Xiuli Wang
Article
Nanoscience & Nanotechnology
Defan Yao, Yanshu Wang, Rongfeng Zou, Kexin Bian, Pei Liu, Shuzhan Shen, Weitao Yang, Bingbo Zhang, Dengbin Wang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Engineering, Biomedical
Weiwei Zeng, Yan Xu, Weitao Yang, Kai Liu, Kexin Bian, Bingbo Zhang
ADVANCED HEALTHCARE MATERIALS
(2020)
Review
Engineering, Biomedical
Yan Xu, Weitao Yang, Bingbo Zhang
Summary: Optical imaging is a useful tool for visualizing biological processes and disease progression, but its image quality is often compromised by background signals. To address this issue, low-background optical imaging techniques such as chemiluminescence imaging, afterglow imaging, and photoacoustic imaging have been developed. Stimuli-responsive probes, particularly those sensitive to reactive oxygen species, offer promise for improving imaging quality by reducing interference signals.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hui Wang, Weitao Yang, Kexin Bian, Weiwei Zeng, Xiao Jin, Ruizhuo Ouyang, Yan Xu, Chenyu Dai, Shuang Zhou, Bingbo Zhang
Summary: This research reports that oxygen-deficient black BiOCl nanoplates, treated with UV excitation, can generate stronger singlet oxygen under ultrasound stimulation. Furthermore, incorporating the GSH biosynthesis inhibitor BSO into BiOCl NPs resulted in enhanced ROS production, especially in the presence of overexpressed GSH in tumors. The findings highlight the potential of using this multifunctional approach for improving sonodynamic therapy in cancer treatment.
Article
Chemistry, Multidisciplinary
Kexin Bian, Weitao Yang, Yan Xu, Weiwei Zeng, Hui Wang, Hongying Liang, Tianming Cui, Zhuo Wang, Bingbo Zhang
Summary: This study demonstrates the importance of the reduction potential state of sonosensitizers in reactive oxygen species (ROS) generation. The reduction potential of band-edge is found to be critical, especially when aligned with the reduction of oxygen. Additionally, ultrasound-generated oxidation holes are effective in consuming overexpressed glutathione, enhancing cellular oxidative stress and inducing tumor cell death. The intrinsic fluorescence property of semiconductors provides imaging capability and guides the sonodynamic therapy (SDT) process.
Article
Chemistry, Multidisciplinary
Yan Xu, Weitao Yang, Yi Han, Kexin Bian, Weiwei Zeng, Liangwen Hao, Hui Wang, Yingsheng Cheng, Peijun Wang, Bingbo Zhang
Summary: This study presents a biomimetic strategy using albumin as a mediator for the synthesis of highly active molybdenum sulfide nanocatalysts, capable of generating singlet oxygen and superoxide anion simultaneously. These reactive oxygen species activate the ferroptosis pathway and cause efficient cancer therapy. The catalytic activity of the nanocatalysts is visualized in situ and a catalytic imaging modality for specific imaging of inflammation diseases is developed based on this biomimetic strategy.
Article
Chemistry, Multidisciplinary
Weitao Yang, Cuijun Deng, Xiudong Shi, Yan Xu, Chenyu Dai, Hui Wang, Kexin Bian, Tianming Cui, Bingbo Zhang
Summary: This study presents a structural and molecular fusion MRI nanoprobe for differential diagnosis of benign and malignant tumors. The nanoprobe enables both structural and molecular imaging of tumors, and can catalyze chemodynamic therapy within the tumor. This innovative nanoprobe strategy allows for the diagnosis of tumors from both spatial and molecular perspectives in a single-step MRI imaging, with potential applications in precision intervention.
Article
Engineering, Biomedical
Jun Wang, YanYan Wu, Kai Liu, Weitao Yang, Weiwei Zeng, Xiaolong Gao, ShiYuan Liu, Bingbo Zhang
Summary: The development of a pH/thermal dual-responsive multifunctional drug delivery system based on polydopamine-coated mesoporous silica-gold nanorods (PDA-AuNRs@MSN) could enhance therapeutic efficacy by combining chemo and photothermal therapy.
APL BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Lu Yu, Aokun Liu, Bingbo Zhang, Jian Kuang, Xiaoqi Guo, Changlin Tian, Yi Lu
Summary: The EPR-based method presented in this study uses dual paramagnetically-labeled probes to detect protease activity, allowing for direct quantitative enzymatic kinetic assessment and screening of protease inhibitors.
CHEMICAL COMMUNICATIONS
(2021)
Review
Nanoscience & Nanotechnology
Xiao Jin, Weitao Yang, Yan Xu, Kexin Bian, Bingbo Zhang
Summary: MRI is a noninvasive technique with high spatial resolution, but traditional contrast agents always have poor target-to-background signal ratio. Activatable CAs with design strategies such as ion conversion, self-assembly, and disassembly significantly improve the TBR and show advantages in biomedical applications compared to conventional CAs.
Article
Chemistry, Multidisciplinary
Yan Xu, Weitao Yang, Defan Yao, Kexin Bian, Weiwei Zeng, Kai Liu, Dengbin Wang, Bingbo Zhang
Article
Materials Science, Biomaterials
Pei Liu, Weitao Yang, Lei Shi, Haiyan Zhang, Yan Xu, Peiru Wang, Guolong Zhang, Wei R. Chen, Bingbo Zhang, Xiuli Wang
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Chemistry, Multidisciplinary
Defan Yao, Shuyan Yang, Yanshu Wang, Kexin Bian, Weitao Yang, Dengbin Wang, Bingbo Zhang
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.