Article
Cell Biology
Lingwei Wang, Gang Liu, Enkhbat Bolor-Erdene, Qinchuan Li, Yunqing Mei, Lei Zhou
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and aggressive tumor with poor long-term survival rates. Through gene expression analysis, KIF4A was found to be overexpressed in ESCC tissues and cells, associated with poor prognosis. KIF4A may serve as diagnostic and prognostic biomarkers and potential therapeutic targets in ESCC patients.
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Weina Li, Xiangdong Bai, Ruyuan Guo, Xiaolong Xing, Huanhu Zhang, Xuezhen Gao
Summary: A study found that miR-137 is down-regulated in esophageal squamous cell carcinoma (ESCC) and is inversely correlated with the 5-year survival rate of patients. Up-regulated miR-137 can inhibit cancer cell proliferation and promote apoptosis. The study also revealed that miR-137 exerts its function by repressing the expression of DAAM1, and reintroduction of DAAM1 can reverse the negative role of miR-137.
PROTEIN AND PEPTIDE LETTERS
(2022)
Article
Oncology
Njainday Pulo Jobe, Lisa Asberg, Tommy Andersson
Summary: The study reveals that WNT5A signaling regulates the invasive behavior of melanoma cells by affecting Rho GTPase activity and morphology. Different WNT5A effects on Cdc42 in various melanoma cell types result in distinct invasion morphologies.
MOLECULAR ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jinlong Xu, Jinmei Wang, Lili Liu, Lin Chen, Songliu Hu, Feng Liu
Summary: The study revealed that miR-196b is up-regulated in ESCC and is associated with TNM stage and lymph node metastasis. miR-196b may serve as an independent prognostic marker for ESCC patients. By targeting SOCS2, miR-196b enhances proliferation, migration, and invasion in ESCC.
Retraction
Multidisciplinary Sciences
Chen Li, Lu Lu, Bing Feng, Kai Zhang, Siqi Han, Daorong Hou, Longbang Chen, Xiaoyuan Chu, Rui Wang
Summary: This article has been retracted; for the detailed retraction note, please refer to https://doi.org/10.1038/s41598-023-32251-x.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Mei Wang, Xinxin Zhao, Rong Qiu, Zheng Gong, Feng Huang, Wanjun Yu, Bo Shen, Xin Sha, Haibo Dong, Jiaying Huang, Lin Wang, Wei Zhu, Wenrong Xu
Summary: The study found that LNM-GCs specifically educated BM-MSCs via secretory exosomes, with exosomal Wnt5a identified as a key protein. Exosomes enriched with Wnt5a induced YAP dephosphorylation in BM-MSCs, while those lacking Wnt5a had the opposite effect. Inhibition of the YAP signaling pathway blocked the reprogramming of BM-MSCs by LNM-GC exosomes and serum exosomes.
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Craig S. Thomson, Jay Pundavela, Melissa R. Perrino, Robert A. Coover, Kwangmin Choi, Katherine E. Chaney, Tilat A. Rizvi, David A. Largaespada, Nancy Ratner
Summary: WNT5A acts as a tumor growth inhibitor in MPNST by modulating the tumor microenvironment, but blocking WNT5A accelerates tumor growth in vivo. Inhibiting WNT5A expression with shRNA leads to upregulation of mRNAs associated with extracellular matrix remodeling and immune cell communication in MPNST cells.
Article
Oncology
Jiali Li, Zhenhua Li, Yanzhao Xu, Chao Huang, Baoen Shan
Summary: METTL3 is found to be significantly increased in ESCC tissues and associated with poor prognosis. METTL3 promotes cell proliferation, migration, and invasion in ESCC and achieves this through upregulating the expression of COL12A1 and phosphorylation of RAF/MRK/ERK. Additionally, COL12A1 can counteract the siMETTL3-mediated inhibition of proliferation, migration, and invasion in ESCC.
Article
Genetics & Heredity
Binjun He, Kang Zhang, Xiaoliang Han, Chao Su, Jiaming Zhao, Guoxia Wang, Guzong Wang, Liuya Zhang, Wenbin Hu
Summary: This study found that miRNA-105-5p in blood-derived vesicles promotes the development and progression of esophageal squamous cell carcinoma (ESCC) by regulating SPARCL1 and the FAK/Akt signaling pathway. This suggests that serum vesicles could be a novel therapy for ESCC and miRNA-105-5p could be a potential target for ESCC treatment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yang Liu, Lin Kang, Shao-Min Shi, Bing-Jie Li, Yang Zhang, Xiu-Zhi Zhang, Xiao-Wan Guo, Gang Fu, Guo-Na Zheng, Han Hao, Huan-Fen Zhao
Summary: The study found that skimmianine (SK) has potential anti-tumor effects on esophageal squamous cell carcinoma (ESCC) by regulating the cell cycle, inhibiting cell migration and invasion, and blocking the ERK1/2 signaling pathway.
Article
Cell Biology
Vanja Krneta-Stankic, Mark E. Corkins, Adriana Paulucci-Holthauzen, Malgorzata Kloc, Andrew B. Gladden, Rachel K. Miller
Summary: The study reveals that Daam1 plays a critical role in regulating E-cadherin-based intercellular adhesion, affecting the assembly and disassembly of cell contacts, and thus impacting the development and homeostasis of epithelial tissues.
Article
Biochemistry & Molecular Biology
Patrik F. Schwarz, Alexander F. Perhal, Lucia N. Schoeberl, Martin M. Kraus, Johannes Kirchmair, Verena M. Dirsch
Summary: The natural product diosgenin has been identified as a direct ligand and inverse agonist of the nuclear receptor ROR alpha and ROR gamma. This finding provides a direct molecular target for diosgenin and explains its role in amending Th17-driven diseases.
Article
Oncology
Changjin Lin, Yujun Wei, Xinchun Duan, Chunquan Liu, Yanlin Du, Xiaoran Wang, Yi Luo, Yong Cui
Summary: This study uncovered a novel molecular pathway in ESCC progression, which might provide potential biomarkers for ESCC diagnosis.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Wei Hou, Yangyang Li, Wenjie Kang, Xin Wang, Xuping Wu, Shouyu Wang, Fei Liu
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Analytical
Wenjie Kang, Huachuan Huang, Ming Cai, Yangyang Li, Wei Hou, Feng Yun, Xuping Wu, Liang Xue, Shouyu Wang, Fei Liu
ANALYTICA CHIMICA ACTA
(2019)
Article
Biophysics
Yanke Shan, Bin Wang, Huachuan Huang, Dan Jiang, Xuping Wu, Liang Xue, Shouyu Wang, Fei Liu
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Multidisciplinary Sciences
Yongbo Yang, Jian Wang, Qun Liang, Yi Wang, Xinhua Chen, Qingrong Zhang, Shijie Na, Yi Liu, Ting Yan, Chunhua Hang, Yichao Zhu
Article
Oncology
Jiayan Li, Guogang Dong, Jinyun Song, Guolei Tan, Xuping Wu
Article
Multidisciplinary Sciences
Zhifang Ma, Jie Chen, Ting Luan, Chengzhuo Chu, Wangfei Wu, Yichao Zhu, Yun Gu
Article
Multidisciplinary Sciences
Xuping Wu, Qi Wang, Yousheng Lu, Jinye Zhang, Hanwei Yin, Yongxiang Yi
Summary: Thioredoxin reductase (TrxR) as a core tumor marker in liver cancer patients shows superior performance compared to AFP, CEA, and CA19-9. TrxR also demonstrates better effectiveness in evaluating chemotherapy outcomes. In chemotherapy-resistant patients and liver metastasis patients, TrxR exhibits higher activity levels than other general markers.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Guolei Tan, Zhongjie Fei, Rongbin Wei, Xuping Wu, Pengfeng Xiao
Summary: The study developed a new bioluminescent pyrophosphate detection method to increase the sensitivity of hepatitis B virus detection, surpassing traditional methods and providing rapid analysis. By using 2-deoxyadenosine-5-(alpha-thio)-triphosphate instead of dATP, the detection method was improved and the results were stable and reliable.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Leiyu Hao, Fengru Huang, Xinqian Yu, Bujie Xu, Yan Liu, Yan Zhang, Yichao Zhu
Summary: This study found that transcriptional levels of EGR1/2/3 were significantly lower in BRCA than in normal tissues, while EGR4 showed an adverse expression pattern. Survival analysis revealed that upregulated EGR1-4 were significantly associated with favorable relapse-free survival (RFS) in breast cancer.
FRONTIERS IN GENETICS
(2021)
Article
Biophysics
Jiahao Li, Xuping Wu, Yue Li, Xin Wang, Huachuan Huang, Dan Jian, Yanke Shan, Yue Zhang, Chengcheng Wu, Guolei Tan, Shouyu Wang, Fei Liu
Summary: This smartphone-based HBV detecting technique offers a cost-effective, portable and user-friendly solution for HBV detection in underdeveloped areas. It has high sensitivity and accuracy, quantifies HBV viral load quickly, and has the potential for mobile HBV diagnoses and sharing epidemic information in resource-limited situations.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Qin Zhang, Jiahao Li, Yue Li, Guolei Tan, Mei Sun, Yanke Shan, Yue Zhang, Xin Wang, Keyu Song, Rui Shi, Ling Huang, Fei Liu, Yongxiang Yi, Xuping Wu
Summary: The development of reliable and fast diagnostic devices for COVID-19 is crucial. In this study, a new analysis principle combining reverse transcription and isothermal amplification with CRISPR/Cas13a reaction was proposed. The method showed good sensitivity and specificity in detecting the SARS-CoV-2 gene fragment, and results could be obtained within 1 hour using a portable device. This approach has the potential for point-of-care screening in remote areas with limited resources.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Infectious Diseases
Ruixian Zhang, Sha Luo, Nan Wang, Hongying Zhang, Xuping Wu
Summary: The study evaluated the minimal inhibitory concentration (MIC) of bedaquiline, clofazimine, linezolid, delamanid, and pretomanid for the treatment of Mycobacterium abscessus and Mycobacterium intracellulare in vitro. The results showed that bedaquiline, clofazimine, and linezolid were more effective in inhibiting the growth of these bacteria, while delamanid and pretomanid had limited efficacy. The mutation in the MAB_0540 gene may be associated with clofazimine resistance in M. abscessus.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Nan Wang, Xia Xiong, Zhiqi Liu, Ruixian Zhang, Sha Luo, Hongying Zhang, Xuping Wu
Summary: This study investigated the prevalence of integrase inhibitor resistance-related mutations and other drug resistance-related mutations among newly diagnosed ART-naive HIV-positive patients in Nanjing, China. It was found that a few patients had major integrase resistance-related mutations and others had accessory resistance-related mutations. These results highlight the importance of further molecular surveillance-based monitoring of the HIV epidemic in Nanjing.
MICROBIAL PATHOGENESIS
(2023)
Letter
Medicine, Research & Experimental
Jie Mei, Honghong Fan, Jiaofeng Zhou, Dingwei Huang, Junying Xu, Yichao Zhu
Article
Oncology
Ting Yan, Xiaping Wang, Guohua Wei, Hai Li, Leiyu Hao, Yan Liu, Xinqian Yu, Wei Zhu, Ping Liu, Yichao Zhu, Xin Zhou
Summary: MiR-10b-5p is highly expressed in advanced stage gastric cancer patients, targeting PTEN in GC cells and KLFII in fibroblasts, regulating the PI3K/Akt/mTORC1 signaling pathway. Exosomal miR-10b-5p promotes proliferation of GC cells, while miR-10b-5p inhibitor reduces cell growth and viability.