期刊
NATIONAL SCIENCE REVIEW
卷 6, 期 4, 页码 810-824出版社
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwz049
关键词
genomics; genome-wide association studies (GWAS); breed; selection; variation; evolution
资金
- Breakthrough Project of the Strategic Priority Program of the Chinese Academy of Sciences (CAS) [XDB13000000]
- National Natural Science Foundation of China [91731304, 31621062]
- Intramural Program of the National Human Genome Research Institute of the National Institutes of Health, USA
- CAS [152453KYSB20150002]
- Morris Animal Foundation
- Swedish Research Council
- European Research Council [ERC-2013-StG-337574-UNDEAD]
- Natural Environmental Research Council [NE/K005243/1, NE/K003259/1]
- grant 'Cani-DNA CRB' for the French Tissue Bank [ANR-11-INBS-0003]
- Young Innovation Promotion Association Award
- NERC [NE/K005243/2, NE/K005243/1, NE/K003259/1] Funding Source: UKRI
Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20x whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.
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