The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Coumarins improved type 2 diabetes induced by high-fat diet and streptozotocin in mice via antioxidation

(2018) Yuanfa Yao et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis

(2018) Joanna Siwinska et al.   JOURNAL OF EXPERIMENTAL BOTANY

Metabolic profiling of corylin in vivo and in vitro

(2018) Zifei Qin et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides

(2018) Zifei Qin et al.   Food & Function

Validated method for quality assessment of henna ( Lawsonia inermis L.) leaves after postharvest blanching and its cosmetic application

(2017) Jyotshna et al.   INDUSTRIAL CROPS AND PRODUCTS

In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes

(2017) Xiaodan Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine

(2017) Na Yang et al.   PHARMACOLOGICAL RESEARCH

Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.

(2017) Zhihong Yao et al.   RSC Advances

Phenolics from Durian Exert Pronounced NO Inhibitory and Antioxidant Activities

(2016) Jianying Feng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Simultaneous determination of fraxin and its metabolite, fraxetin, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

(2016) Haidong Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

α-Glucosidase and α-Amylase Inhibitors from Arcytophyllum thymifolium

(2016) Luigi Milella et al.   JOURNAL OF NATURAL PRODUCTS

Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway

(2016) Meifang Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 by Natural Compounds and Their Derivatives

(2016) Noora Sjöstedt et al.   MOLECULAR PHARMACEUTICS

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

(2016) Xuejun Zeng et al.   PLoS One

Antiplatelet activity of flavonoid and coumarin drugs

(2016) Cristina Zaragozá et al.   VASCULAR PHARMACOLOGY

Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling

(2015) Hua Sun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance

(2014) Oliver Bruhn et al.   Expert Opinion on Drug Metabolism & Toxicology

Antibacterial mechanism of fraxetin against Staphylococcus aureus

(2014) HAITING WANG et al.   Molecular Medicine Reports

Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia

(2014) Y Tanaka et al.   PHARMACOGENOMICS JOURNAL

Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe

(2013) Megan K. Thorson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

(2013) Raju Murali et al.   BIOCHIMIE

Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin

(2013) Yang-Liu Xia et al.   Drug Metabolism and Pharmacokinetics

Revolving Door Action of Breast Cancer Resistance Protein (BCRP) Facilitates or Controls the Efflux of Flavone Glucuronides from UGT1A9-Overexpressing HeLa Cells

(2013) Yingjie Wei et al.   MOLECULAR PHARMACEUTICS

A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)

(2012) Baojian Wu et al.   PHARMACEUTICAL RESEARCH

Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics

(2011) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics

(2011) Baojian Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

(2008) K. van de Wetering et al.   MOLECULAR PHARMACOLOGY

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

(2008) F RUSSEL et al.   TRENDS IN PHARMACOLOGICAL SCIENCES