Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

Antimicrobial Peptides and Innate Lung Defenses

(2016) Pieter S. Hiemstra et al.   CHEST

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome

(2015) Qiuchan Deng et al.   INFECTION AND IMMUNITY

P2X7Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

(2015) Xiao Tang et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis

(2015) Alessandro Rimessi et al.   Nature Communications

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

(2014) Paula E. Beaumont et al.   PLoS One

Host defense peptides: front-line immunomodulators

(2014) Sarah C. Mansour et al.   TRENDS IN IMMUNOLOGY

New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

(2013) Dominic De Nardo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

(2013) Emily Gwyer Findlay et al.   BIODRUGS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The inflammasome in lung diseases

(2012) Gimena dos Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia

(2012) M. A. Kovach et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?

(2012) Fiona Semple et al.   Journal of Innate Immunity

Inflammasome-Mediated IL-1β Production in Humans with Cystic Fibrosis

(2012) Anthony Tang et al.   PLoS One

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

(2010) Peter G. Barlow et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

(2009) Hsin-Ni Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Host Defense Peptide LL-37 Selectively Permeabilizes Apoptotic Leukocytes

(2008) A. Bjorstad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA