Varicose veins of lower extremities: Insights from the first large-scale genetic study

Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins

(2018) A. Shadrina et al.   CLINICAL GENETICS

Genome-wide association study in ethnic Russians suggests an association of the MHC class III genomic region with the risk of primary varicose veins

(2018) Alexandra Shadrina et al.   GENE

Pathophysiology of Chronic Venous Disease and Venous Ulcers

(2018) Joseph D. Raffetto   SURGICAL CLINICS OF NORTH AMERICA

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease

(2018) Mariya A Smetanina et al.   Epigenomics

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

A network-based conditional genetic association analysis of the human metabolome

(2018) Y A Tsepilov et al.   GigaScience

Prevalence and Risk Factors for Chronic Venous Disease in the General Russian Population

(2017) Igor A. Zolotukhin et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Conditional analysis of multiple quantitative traits based on marginal GWAS summary statistics

(2017) Yangqing Deng et al.   GENETIC EPIDEMIOLOGY

The druggable genome and support for target identification and validation in drug development

(2017) Chris Finan et al.   Science Translational Medicine

Connecting genetic risk to disease end points through the human blood plasma proteome

(2017) Karsten Suhre et al.   Nature Communications

Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci

(2017) Eva Ellinghaus et al.   Scientific Reports

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

(2017) Chani J. Hodonsky et al.   PLoS Genetics

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Are Inflammatory Biomarkers Increased in Varicose Vein Blood?

(2016) Christopher R. Lattimer et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Genetics in chronic venous disease

(2016) Yasmin Grant et al.   PHLEBOLOGY

Biomolecular Mechanisms in Varicose Veins Development

(2015) Oliwia Anna Segiet et al.   ANNALS OF VASCULAR SURGERY

HFE p.C282Y gene variant is associated with varicose veins in Russian population

(2015) Ekaterina A. Sokolova et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The molecular regulation of arteriovenous specification and maintenance

(2015) Jason E. Fish et al.   DEVELOPMENTAL DYNAMICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of varicose veins - lessons from biomechanics

(2014) Larissa Pfisterer et al.   Vasa-European Journal of Vascular Medicine

Venous Thromboembolism and Varicose Veins Share Familial Susceptibility: A Nationwide Family Study in Sweden

(2014) Bengt Zöller et al.   Journal of the American Heart Association

Hypoxia-inducible factor pathway and diseases of the vascular wall

(2013) Chung S. Lim et al.   JOURNAL OF VASCULAR SURGERY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Varicose veins are a risk factor for deep venous thrombosis in general practice patients

(2013) Müller-Bühl et al.   Vasa-European Journal of Vascular Medicine

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Evidence for a genetic role in varicose veins and chronic venous insufficiency

(2012) J Krysa et al.   PHLEBOLOGY

Epidemiological study on varicose veins in Budapest

(2011) I Bihari et al.   PHLEBOLOGY

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pathogenesis of primary varicose veins

(2009) C. S. Lim et al.   BRITISH JOURNAL OF SURGERY

Varicose Veins Show Enhanced Chemokine Expression

(2009) L. del Rio Solá et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis

(2008) Karen Piper Hanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY