Article
Critical Care Medicine
Jean Chastre, Bruno Francois, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sanchez-Garcia, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali, Kathryn Shoemaker, Pin Ren, Julien Sauser, Alexey Ruzin, David E. Tabor, Ahmad Akhgar, Yuling Wu, Yu Jiang, Antonio DiGiandomenico, Susan Colbert, Drieke Vandamme, Frank Coenjaerts, Surbhi Malhotra-Kumar, Leen Timbermont, Antonio Oliver, Olivier Barraud, Terramika Bellamy, Marc Bonten, Herman Goossens, Colin Reisner, Mark T. Esser, Hasan S. Jafri
Summary: This study assessed the effectiveness of the bivalent, bispecific monoclonal antibody MEDI3902 in preventing hospital-acquired pneumonia caused by Pseudomonas aeruginosa. The results showed that MEDI3902 did not reduce the incidence of pneumonia in Pseudomonas aeruginosa carriers.
Review
Immunology
Seyedeh Zohreh Mirjalili, Reyhaneh Sabourian, Mona Sadeghalvad, Nima Rezaei
Summary: Biosimilars are cost-effective alternatives to reference biological drugs for treating autoimmune disorders. Research indicates that biosimilar mAbs show similarity with reference products in terms of safety and efficacy, making them potential candidates for a wider range of diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Sumathi Sivapalasingam, David J. Lederer, Rafia Bhore, Negin Hajizadeh, Gerard Criner, Romana Hosain, Adnan Mahmood, Angeliki Giannelou, Selin Somersan-Karakaya, Meagan P. O'Brien, Anita Boyapati, Janie Parrino, Bret J. Musser, Emily Labriola-Tompkins, Divya Ramesh, Lisa A. Purcell, Daya Gulabani, Wendy Kampman, Alpana Waldron, Michelle Ng Gong, Suraj Saggar, Steven J. Sperber, Vidya Menon, David K. Stein, Magdalena E. Sobieszczyk, William Park, Judith A. Aberg, Samuel M. Brown, Jack A. Kosmicki, Julie E. Horowitz, Manuel A. Ferreira, Aris Baras, Bari Kowal, A. Thomas DiCioccio, Bolanle Akinlade, Michael C. Nivens, Ned Braunstein, Gary A. Herman, George D. Yancopoulos, David M. Weinreich
Summary: This study evaluated the efficacy and safety of sarilumab, an anti-IL-6R monoclonal antibody, in the treatment of hospitalized patients with COVID-19. The results showed that sarilumab did not establish efficacy in severe/critical COVID-19 patients. However, post hoc analysis suggested a potential benefit of sarilumab in patients receiving corticosteroids.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Ivan Titov, Richard G. Wunderink, Antoine Roquilly, Daniel Rodriguez Gonzalez, Aileen David-Wang, Helen W. Boucher, Keith S. Kaye, Maria C. Losada, Jiejun Du, Robert Tipping, Matthew L. Rizk, Munjal Patel, Michelle L. Brown, Katherine Young, Nicholas A. Kartsonis, Joan R. Butterton, Amanda Paschke, Luke F. Chen
Summary: The study demonstrated that imipenem/cilastatin/relebactam and piperacillin/tazobactam had similar efficacy in treating hospital-acquired/ventilator-associated bacterial pneumonia. Imipenem/cilastatin/relebactam showed favorable safety profile in treating HABP/VABP patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Himanshu Upadhyaya, Jenny Y. Chien, Amanda J. Long, Martin Bohm, Nicole Kallewaard, Lisa Macpherson, Dipak Patel, Matthew Hufford, Constance Krull, Jocelyn Ang, Peter Chen, William Muller, Jeffrey Potts, Timothy Quinn, Mark Williams
Summary: This study examined the pharmacokinetics, efficacy, and safety of Bamlanivimab and etesevimab (BAM + ETE) treatment in pediatric patients with COVID-19. The results showed that pediatric patients achieved similar drug exposures as adults and experienced no severe adverse events, suggesting that BAM + ETE treatment is effective and safe in children.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Ole A. Mandrup, Ainhoa Erce-Llamazares, Rodrigo Lazaro-Gorines, Daniel Nehme-Alvarez, Carmen Dominguez-Alonso, Seandean L. Harwood, Carlos Alfonso, Belen Blanco, Laura Rubio-Perez, Anais Jimenez-Reinoso, Laura Diez-Alonso, Francisco J. Blanco, Laura Sanz, Kenneth A. Howard, Luis Alvarez-Vallina
Summary: This study introduces bispecific antibodies fused with human and mouse sequences that specifically target the tumor microenvironment to provide 4-1BB costimulation. These antibodies show specific targeting of the tumor cells and provide costimulatory activity, with prolonged circulatory half-life and tumor inhibition effects. Combining these antibodies with PD-1-blocking antibodies enhances the therapeutic effect.
Review
Endocrinology & Metabolism
Yu Hu, Jinhua Chen, Ken Lin, Xijie Yu
Summary: This meta-analysis compared the efficacy and safety of different monoclonal antibodies for the treatment of Graves' ophthalmopathy (GO), and found that TCZ was the most effective in terms of treatment response and reducing proptosis, while TMB was the most effective in improving diplopia. Based on the best available evidence, TCZ should be the preferred treatment for moderate to severe GO.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemical Research Methods
Bryan Dransart, Houman Dehghani, Alison Moore
Summary: Allogeneic chimeric antigen-receptor T-cell processes involve large-scale cultures and novel processing steps, starting with donor-derived peripheral blood mononuclear cells and generating products for hundreds of patients. The safety considerations are diverse and unique, and the use of regulations and quality design principles is important in ensuring process safety.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemical Research Methods
Bryan Dransart, Houman Dehghani, Alison Moore
Summary: Allogeneic chimeric antigen-receptor T-cell process flows involve traditional and novel processing steps, starting from donor-derived cells to generate batches for treating multiple patients. Diverse unit operation-process safety considerations need to be taken into account to ensure process safety.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Oncology
Hagop M. Kantarjian, Wendy Stock, Ryan D. Cassaday, Daniel J. DeAngelo, Elias Jabbour, Susan M. O'Brien, Matthias Stelljes, Tao Wang, M. Luisa Paccagnella, Kevin Nguyen, Barbara Sleight, Erik Vandendries, Alexander Neuhof, A. Douglas Laird, Anjali S. Advani
Summary: Inotuzumab ozogamicin demonstrated superior response rates, minimal/measurable residual disease negativity, longer duration of remission, and better overall survival compared to standard of care in patients with CD22 positivity >= 90%. Patients with CD22 positivity <90% showed higher response rates with inotuzumab ozogamicin therapy, but similar duration of remission and overall survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Chengxin Luo, Guixian Wu, Xiangtao Huang, Yanni Ma, Yali Zhang, Qiuyue Song, Mingling Xie, Yanni Sun, Yarui Huang, Zhen Huang, Yu Hou, Shuangnian Xu, Jieping Chen, Xi Li
Summary: In comparing new anti-CD20 monoclonal antibodies with rituximab in the induction therapy of CD20(+) B-NHL, it was found that obinutuzumab significantly improved PFS but had higher incidence of adverse events, ofatumumab decreased ORR, and Y-90-ibritumomab tiuxetan increased ORR.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe A. Ramirez, Maria Gerosa, Chiara Bellocchi, Daniel Arroyo-Sanchez, Chiara Asperti, Lorenza M. Argolini, Gabriele Gallina, Martina Cornalba, Isabella Scotti, Ilaria Suardi, Luca Moroni, Lorenzo Beretta, Enrica P. Bozzolo, Roberto Caporali, Lorenzo Dagna
Summary: Research on the treatment of COVID-19 in SLE patients suggests that anti-SARS-CoV-2 antiviral agents and monoclonal antibodies may be safely and effectively used in these patients, especially in those with active disease and severe COVID-19 symptoms at presentation.
Article
Immunology
Simone Mornese Pinna, Tommaso Lupia, Silvia Scabini, Davide Vita, Ilaria De Benedetto, Alberto Gaviraghi, Irene Colasanto, Alessandra Varese, Francesco Cattel, Francesco Giuseppe De Rosa, Silvia Corcione
Summary: This article discusses the largest vaccination effort in history to end the COVID-19 pandemic, the use of monoclonal antibodies against SARS-CoV-2, and the impact of mutations on vaccine effectiveness. It summarizes the content of clinical trials and existing research on these topics.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Jon Bruss, Troy Lister, Vipul K. Gupta, Emily Stone, Lisa Morelli, Yang Lei, David Melnick
Summary: SPR206, a novel polymyxin derivative, shows potent activity against multidrug-resistant bacteria and demonstrates good safety and tolerability in healthy subjects. Drug exposure and excretion are dose-dependent, with minimal accumulation and no evidence of nephrotoxicity observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Analytical
Ramon E. Cevallos-Cedeno, Guillermo Quinones-Reyes, Consuelo Agullo, Antonio Abad-Somovilla, Antonio Abad-Fuentes, Josep Mercader
Summary: Sensitive and selective immunological assays for anatoxin-a have been developed using homemade monoclonal antibodies. The assays have low detection limits, good recovery rates, and are applicable in different formats. A visual detection method with a relatively low limit of detection has also been optimized. The accuracy of the method has been validated by comparison with high-performance liquid chromatography-tandem mass spectroscopy data.
ANALYTICAL CHEMISTRY
(2022)
Article
Health Care Sciences & Services
Moe H. Kyaw, David M. Kern, Siting Zhou, Ozgur Tunceli, Hasan S. Jafri, Judith Falloon
BMC HEALTH SERVICES RESEARCH
(2015)
Review
Infectious Diseases
T. Kostyanev, M. J. M. Bonten, S. O'Brien, H. Steel, S. Ross, B. Francois, E. Tacconelli, M. Winterhalter, R. A. Stavenger, A. Karlen, S. Harbarth, J. Hackett, H. S. Jafri, C. Vuong, A. MacGowan, A. Witschi, G. Angyalosi, J. S. Elborn, R. dewinter, H. Goossens
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Katherine L. O'Brien, Aruna Chandran, Robert Weatherholtz, Hasan S. Jafri, M. Pamela Griffin, Terramika Bellamy, Eugene V. Millar, Kathryn M. Jensen, Brian S. Harris, Raymond Reid, Lawrence H. Moulton, Genevieve A. Losonsky, Ruth A. Karron, Mathuram Santosham
LANCET INFECTIOUS DISEASES
(2015)
Article
Microbiology
David E. Tabor, Li Yu, Hoyin Mok, Christine Tkaczyk, Bret R. Sellman, Yuling Wu, Vaheh Oganesyan, Tim Slidel, Hasan Jafri, Michael McCarthy, Patricia Bradford, Mark T. Esser
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Immunology
Bruno Francois, Jean Chastre, Philippe Eggiman, Pierre-Francois Laterre, Antoni Torres, Miguel Sanchez, Mark T. Esser, Brian Bishop, Marc Bonten, Herman Goosens, Hasan S. Jafri
CLINICAL INFECTIOUS DISEASES
(2016)
Editorial Material
Critical Care Medicine
Bruno Francois, Hasan S. Jafri, Marc Bonten
INTENSIVE CARE MEDICINE
(2016)
Article
Immunology
Rosa Rodriguez-Fernandez, Lorena I. Tapia, Chin-Fen Yang, Juan Pablo Torres, Susana Chavez-Bueno, Carla Garcia, Lisa M. Jaramillo, Melissa Moore-Clingenpeel, Hasan S. Jafri, Mark E. Peeples, Pedro A. Piedra, Octavio Ramilo, Asuncion Mejias
JOURNAL OF INFECTIOUS DISEASES
(2018)
Review
Critical Care Medicine
Bruno Francois, Charles-Edouard Luyt, C. Kendall Stover, Jeffery O. Brubaker, Jean Chastre, Hasan S. Jafri
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Microbiology
Thomas J. Walsh, Timothy Driscoll, Peter A. Milligan, Nolan D. Wood, Haran Schlamm, Andreas H. Groll, Hasan Jafri, Antonio C. Arrieta, Nigel J. Klein, Irja Lutsar
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2010)
Article
Microbiology
Batu K. Sharma-Kuinkel, Yuling Wu, David E. Tabor, Hoyin Mok, Bret R. Sellman, Amy Jenkins, Li Yu, Hasan S. Jafri, Thomas H. Rude, Felicia Ruffin, Wiley A. Schell, Lawrence P. Park, Qin Yan, Joshua T. Thaden, Julia A. Messina, Vance G. Fowler, Mark T. Esserb
JOURNAL OF CLINICAL MICROBIOLOGY
(2015)
Article
Immunology
Hasan S. Jafri, Xionghua Wu, Doris Makari, Kelly J. Henrickson
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2013)
Review
Multidisciplinary Sciences
Ellen Korol, Karissa Johnston, Nathalie Waser, Frangiscos Sifakis, Hasan S. Jafri, Mathew Lo, Moe H. Kyaw
Article
Infectious Diseases
Gabriel J. Robbie, Doris Makari, Brian Harris, Genevieve A. Losonsky, Hasan S. Jafri
INFECTIOUS DISEASES AND THERAPY
(2014)
Article
Infectious Diseases
Doris Makari, Kathryn M. Jensen, Brian Harris, Hasan S. Jafri
INFECTIOUS DISEASES AND THERAPY
(2014)