Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Synaptic release of acetylcholine rapidly suppresses cortical activity by recruiting muscarinic receptors in layer 4

(2018) Rajan Dasgupta et al.   JOURNAL OF NEUROSCIENCE

Preferential cholinergic excitation of corticopontine neurons

(2018) Arielle L. Baker et al.   JOURNAL OF PHYSIOLOGY-LONDON

Precisely Timed Nicotinic Activation Drives SST Inhibition in Neocortical Circuits

(2018) Joanna Urban-Ciecko et al.   NEURON

Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex

(2018) Daniel W. Sparks et al.   Frontiers in Neural Circuits

Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems

(2018) Jennifer J. Coppola et al.   Frontiers in Neural Circuits

Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex

(2018) Gabriele Radnikow et al.   Frontiers in Neuroanatomy

Rapid Neuromodulation of Layer 1 Interneurons in Human Neocortex

(2018) Rogier B. Poorthuis et al.   Cell Reports

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Membrane Potential Correlates of Network Decorrelation and Improved SNR by Cholinergic Activation in the Somatosensory Cortex

(2018) Inbal Meir et al.   JOURNAL OF NEUROSCIENCE

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

(2018) Srikanth Ramaswamy et al.   Frontiers in Neural Circuits

Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex

(2018) Joshua Obermayer et al.   Nature Communications

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

(2017) Fani Koukouli et al.   NATURE MEDICINE

Cholinergic shaping of neural correlations

(2017) Victor Minces et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layer-specific modulation of neocortical dendritic inhibition during active wakefulness

(2017) William Muñoz et al.   SCIENCE

Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain

(2017) Joshua Obermayer et al.   Frontiers in Neural Circuits

Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation

(2017) Markus M. Hilscher et al.   PLOS BIOLOGY

Selectivity of Neuromodulatory Projections from the Basal Forebrain and Locus Ceruleus to Primary Sensory Cortices

(2016) Jae-Hyun Kim et al.   JOURNAL OF NEUROSCIENCE

A unifying hypothesis for M1 muscarinic receptor signalling in pyramidal neurons

(2016) Sameera Dasari et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cell-specific modulation of plasticity and cortical state by cholinergic inputs to the visual cortex

(2016) Hiroki Sugihara et al.   JOURNAL OF PHYSIOLOGY-PARIS

Cotransmission of acetylcholine and GABA

(2016) Adam J. Granger et al.   NEUROPHARMACOLOGY

Modulation of Specific Sensory Cortical Areas by Segregated Basal Forebrain Cholinergic Neurons Demonstrated by Neuronal Tracing and Optogenetic Stimulation in Mice

(2016) Irene Chaves-Coira et al.   Frontiers in Neural Circuits

Nicotinic Transmission onto Layer 6 Cortical Neurons Relies on Synaptic Activation of Non-α7 Receptors

(2015) Y. Audrey Hay et al.   CEREBRAL CORTEX

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors

(2015) Tristan Hedrick et al.   JOURNAL OF NEUROPHYSIOLOGY

Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition

(2015) S.-C. Lin et al.   JOURNAL OF NEUROSCIENCE

An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity

(2015) Naiyan Chen et al.   NATURE NEUROSCIENCE

Basal forebrain circuit for sleep-wake control

(2015) Min Xu et al.   NATURE NEUROSCIENCE

Diversity of native nicotinic receptor subtypes in mammalian brain

(2015) Michele Zoli et al.   NEUROPHARMACOLOGY

Basal forebrain control of wakefulness and cortical rhythms

(2015) Christelle Anaclet et al.   Nature Communications

Corelease of acetylcholine and GABA from cholinergic forebrain neurons

(2015) Arpiar Saunders et al.   eLife

Spatiotemporal specificity in cholinergic control of neocortical function

(2014) William Muñoz et al.   CURRENT OPINION IN NEUROBIOLOGY

M3 Muscarinic Receptor Interaction with Phospholipase C β3 Determines Its Signaling Efficiency

(2014) Wei Kan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylcholine functionally reorganizes neocortical microcircuits

(2014) Melissa J. Runfeldt et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuromodulators Produce Distinct Activated States in Neocortex

(2014) M. A. Castro-Alamancos et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Modulation of Layer 1 Inhibitory Neocortical Circuits by Acetylcholine

(2014) A. Brombas et al.   JOURNAL OF NEUROSCIENCE

Cholinergic circuit modulation through differential recruitment of neocortical interneuron types during behaviour

(2014) Rogier B. Poorthuis et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Nicotinic Acetylcholine Receptor  5 Subunit Plays a Key Role in Attention Circuitry and Accuracy

(2013) C. D. C. Bailey et al.   JOURNAL OF NEUROSCIENCE

The organization of two new cortical interneuronal circuits

(2013) Xiaolong Jiang et al.   NATURE NEUROSCIENCE

Layer-Specific Modulation of the Prefrontal Cortex by Nicotinic Acetylcholine Receptors

(2012) Rogier B. Poorthuis et al.   CEREBRAL CORTEX

Selective optogenetic stimulation of cholinergic axons in neocortex

(2012) Abigail Kalmbach et al.   JOURNAL OF NEUROPHYSIOLOGY

Cholinergic-mediated response enhancement in barrel cortex layer V pyramidal neurons

(2012) Angel Nuñez et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuromodulation of Ih in Layer II Medial Entorhinal Cortex Stellate Cells: A Voltage-Clamp Study

(2012) J. G. Heys et al.   JOURNAL OF NEUROSCIENCE

Contribution of Cholinergic and GABAergic Mechanisms to Direction Tuning, Discriminability, Response Reliability, and Neuronal Rate Correlations in Macaque Middle Temporal Area

(2012) A. Thiele et al.   JOURNAL OF NEUROSCIENCE

Prolonged Disynaptic Inhibition in the Cortex Mediated by Slow, Non- 7 Nicotinic Excitation of a Specific Subset of Cortical Interneurons

(2012) S. Arroyo et al.   JOURNAL OF NEUROSCIENCE

Neuromodulation of Brain States

(2012) Seung-Hee Lee et al.   NEURON

Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology

(2012) Cagri T. Unal et al.   Frontiers in Behavioral Neuroscience

Effects of acetylcholine on neuronal properties in entorhinal cortex

(2012) James G. Heys et al.   Frontiers in Behavioral Neuroscience

Cholinergic modulation of cognitive processing: insights drawn from computational models

(2012) Ehren L. Newman et al.   Frontiers in Behavioral Neuroscience

Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

(2011) Adrian Gericke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A disinhibitory microcircuit for associative fear learning in the auditory cortex

(2011) Johannes J. Letzkus et al.   NATURE

Localisation of pre- and postsynaptic cholinergic markers in the human brain

(2010) Andrea Wevers   BEHAVIOURAL BRAIN RESEARCH

The neuronal nicotinic α4β2 receptor has a high maximal probability of being open

(2010) Ping Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabotropic Induction of Persistent Activity in Layers II/III of Anterior Cingulate Cortex

(2010) Z. Zhang et al.   CEREBRAL CORTEX

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

Postsynaptic Cell Type–Dependent Cholinergic Regulation of GABAergic Synaptic Transmission in Rat Insular Cortex

(2010) Kiyofumi Yamamoto et al.   JOURNAL OF NEUROPHYSIOLOGY

Preferential Localization of Muscarinic M1 Receptor on Dendritic Shaft and Spine of Cortical Pyramidal Cells and Its Anatomical Evidence for Volume Transmission

(2010) M. Yamasaki et al.   JOURNAL OF NEUROSCIENCE

Acetylcholine Receptor (AChR)  5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces ( 4 2)2 5 AChR Function

(2010) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

(2010) Michael E Hasselmo et al.   NEUROPSYCHOPHARMACOLOGY

Presynaptic nicotinic receptors modulating neurotransmitter release in the Central Nervous System: Functional interactions with other coexisting receptors

(2010) Mario Marchi et al.   PROGRESS IN NEUROBIOLOGY

Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system

(2009) Jian-xin Shen et al.   ACTA PHARMACOLOGICA SINICA

Basal forebrain activation enhances cortical coding of natural scenes

(2009) Michael Goard et al.   NATURE NEUROSCIENCE

Phasic acetylcholine release and the volume transmission hypothesis: time to move on

(2009) Martin Sarter et al.   NATURE REVIEWS NEUROSCIENCE

Molecular Mechanisms of Go Signaling

(2009) Meisheng Jiang et al.   NEUROSIGNALS

Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4

(2009) Emmanuel Eggermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons

(2008) Pablo Henny et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Acetylcholine receptors in dementia and mild cognitive impairment

(2008) Osama Sabri et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Selective, State-Dependent Activation of Somatostatin-Expressing Inhibitory Interneurons in Mouse Neocortex

(2008) Erika E. Fanselow et al.   JOURNAL OF NEUROPHYSIOLOGY

Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors

(2008) S. M. Kassam et al.   JOURNAL OF NEUROSCIENCE

Perisomatic GABA Release and Thalamocortical Integration onto Neocortical Excitatory Cells Are Regulated by Neuromodulators

(2008) Illya Kruglikov et al.   NEURON

Zinc Potentiates Neuronal Nicotinic Receptors by Increasing Burst Duration

(2007) Bernard Hsiao et al.   JOURNAL OF NEUROPHYSIOLOGY